Báo cáo y học: " Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1" docx
Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... homeostasis, maintenance of tolerance,and prevention of the onset of autoimmune disease. Theirexistence is no longer in question, but true to their historythese cells, their origin, generation, ... CD4+CD25– T cells, together with TCR antigenstimulation, into the regulatory phenotype. Elemental to thisconversion process is induction of expression of the forkheadtranscription factor, Foxp3. This ... intersection points of such pathways await further study. Among the factors thatcontribute to the regulation of TGF-β in CD4+CD25+Tregare CD28, cytotoxic T lymphocyte antigen-4,glucocorticoid-induced...
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Báo cáo y học: "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is ne" pdf
... IL-10-producing T regulatory 1 cells. Altogether, HSP60 may induce Tregs in the joints of JIA patients and thereby regulate the inflammation of these JIA patients, as is seen in oligoarticular JIA. ... while polyarticular patients did not [65]. This finding suggests a correlationbetween disease severity and HSP60 reactivity of T cells in these patients, in the sense that reactivity to self-HSP60 ... andpathogenic patterns to ensure that they enhance only the tolerogenic effect and do not tip the delicate immune balancetowards inflammation.Competing interests The authors declare that they...
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Báo cáo y học: "CD23+/CD21hi B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice" potx
... collapse due to the transloca-tion of B -in to the lumen of the lymphatic vessels of the nodes. We predict that these translocated B -in cells obstruct the lymphatics of the lower limb resulting in decreased ... signal intensity at the injec-tion site immediately after administration and 24 hourslater. To quantify lymphatic draining in ILN, 6 μlofICG solution was injecte d intraarticularly into the kneecavity. ... contrast,relatively little attention has been directed towards the possible role of local factors in RA flare. The fact thatan RA flare often occurs asymmetrically in the setting of systemic...
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Báo cáo y học: " Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases" docx
... another. The accumulated contributions of synonymous codons of an aminoacid to the total folding energy of an mRNA is strongly correlated to the relative amount of thatamino acid in the translated ... to form structures. However, the FE has only a small free component, less than10% of the total. The contribution of the 1st and 3rd codon bases to the FE is larger than the contribution of the ... SynonymousSNPs do not produce altered coding sequences, so they arenot expected to change the function of the protein in which they occur. However, they often do. SynonymousSNPs in the Multi-drug...
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Báo cáo y học: " Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1" docx
... control T cells are equally susceptible to HIV-1 in the absence of DC, demonstrating that the DC-mediated transmission itself is impaired, instead of the ability of HIV-1 to infectthese cells. The ... smallernumber of T cells that is tightly attached to DC will result in a decrease of the window of opportunity for HIV-1 transmission. Furthermore, it is likely that the creation of an 'infectious synapse' ... Deficiency type1 (LAD-1) patients. Results: We clearly show that DC-mediated HIV-1 transmission to LAD-1 T cells is impaired in comparison to healthy controls. Furthermore, HIV-1 transmission to T cells...
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Báo cáo y học: "HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission" pptx
... respectively. In addition, the 714insT or G is closely flanked by an interferon response factor-1 bindingmotif at the upstream regulatory element of HLA-G gene.Taken together, the data from this study ... to determine the full impact of these HLA-G variants in perinatal HIV-1 transmission. Declaration of competing interests The author(s) declare that they have no competing inter-ests.Authors' ... association of the mutation in exon 2 region at codon 57 with perinatal HIV-1 transmission. The striking difference in the resultsmay be explained by the population structure used in their study...
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Báo cáo y học: "Dendritic cell therapy for oncology roundtable conference Sandra Tuyaerts" doc
... the CRP inflammatory cycle was also raised by BrendonCoventry as a possib ility for patient selection withrespect to timing of administration and targeting of therapy, in or der to induce the desired ... inte ract with T cells. Jeffrey Weber therefore designed a system to attract T cells to the injection site and induce in this way and“artificial lymph nodal aggreg ate” for T cell priming. To achieve ... about dendritic cell (DC)therapy to patients and physicians, the organizing committee felt it necessary to organize this conference to getan up -to- date status of the academic DC therapy field,...
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Báo cáo y học: "Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review." doc
... lymphocytes to mobilize specific immunity [1-4]. By contrast, in order to induce T cell-tolerance in the thymus, DCs present self peptide-MHC complexes to thy-mocytes [5]. The capacity of DCs to initiate ... of regulatory T cells that controlactivated T cells through their suppressive signals. In addi-tion, DCs play an important role in innate immunity bysecreting cytokines, e.g. IL-12 and Interferon ... to the DCs ability to attract and recruit T cells in sites of inflammation. A number of autoimmune diseases (rheu-matoid arthritis) or skin psoriasis demonstrates the accu-mulation of DCs in...
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Báo cáo y học: " Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway" pot
... fully consistent pat-tern when comparing the family transmission and the case-control approach which makes it unlikely that any of the tested SNPs is already an important functional variant. The ... laboratory anal-ysis, did statistical analysis and wrote the report. J.A. did the clinical survey, C.B. did the SNP analysis, M.B. builtserum and DNA bank and did the vitamin D assaystogether ... associations may instead indicate the effects of physically closely related variants in these genes (which is also supported by the haplotype results of CYP24A1). The associated candidate genes...
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Báo cáo y học: "Dendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques" pptx
... relative to the hypothesis that apoptosis of DC induced by HIV and/or migration of mature DC into the lymph node. The function of DC was impaired accompanying with the decline of cell number. Both ... chroni-cally HIV-infected patients [32,37]. The IFN-a mainly secreted by pDC exerts a stronganti-HIV activity not only directly, b ut also indirectlythrough the act ivation of the immune system. DuringSIVmac239 ... stimulations [5]. Then virus-activated pDC dif-ferentiate into a unique type of mature DC, which prob-ably play a role in the initiation of the T- cell response in a manner similar to that of...
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