Báo cáo y học: "Unmeasured anions: the unknown unknown" pot

... alkalosis canmask their presence. Likely culprits vary with the clinicalscenario, but the search usually starts with L-lactate and β-hydroxybutyrate. During this process, stoichiometry is trackedbetween ... likely.Unfortunately, the AG is a flawed instrument. Both sensitivityand specificity are reduced by perturbations of albumin(remembering that albumin negative charge forms the bulk of the normal ... Potential candidates include L-lactate, β-hydroxy-butyrate, D-lactate, salicylate, formate and oxalate in toxi-cological situations, pyroglutamate, semisynthetic penicillins,sulphate and hippurate...

Báo cáo y học: "Unmeasured anions in metabolic acidosis: unravelling the mystery" pps

... where the largepeaks attributable to acetoacetate and β-hydroxybutyrate areclearly seen [24].These preliminary results led us to examine the anions of the Krebs cycle using enzyme assay (we ... anions usually associated with the Krebscycle may contribute to the observed anion or ‘strong-ion’gap. Although these observations go no way to explainingtheir genesis, they may provide the first ... convertedto phosphoenolpyruvate and is lost to the Krebs cycle.Lipogenesis requires the transfer of citrate from the mitochondria to the cytosol as that is the site at which the synthetic process occurs....

Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"

... step forwards to assess the utility of thesequestionnaires in another practice setting.Therefore the aim of this observational study was toassess the utility of the MYMOP2 and W-BQ12 healthoutcomes ... utilised for the study.Patients were invited to participate in the study if theywere: over the age of 18 years; had no treatment fromany health professional for their complaint in the preced-ing ... other than the Activity scale of the MYMOP2 which had no significantcorrelations with any of the W-BQ12 scales (see Table 3).MYMOP2hasbeenshowntobehighlyresponsivetochanges in symptoms whether...

Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"

... with great bravery to return to the clinicand to obtain their medication refills.▪ Patients really surprised us. They walked distances, theyran away, they tried again, they came back. I remember ... them to go on the roads and try toget [to clinic]. The risks to personal safety were seen to vary based on the fam-ilies' tribal affiliation, their location, and whether they were in the ... dif-ficulty returning to care. Younger children may have beenat greater distances from the clinics than older childrensince they were described as being "like another luggageyou carry on your...

Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"

... 5. de Godoy JM, de Godoy Mde F. Physiopathological hypothesis of cellulite. Open Cardiovasc Med J. 2009;31(3):96-7. 6. Godoy JMP, Almeida EMMZNM, Silva SH, Godoy MFG. Pilot study of the intensive ... until the edema is controlled. Another important aspect to be analyzed is the assessment of all changes that may lead to tissue ac-cumulation such as in obesity, lipedema and lymphedema; the ... specifically in relation to edema. The observation of cyclic edema demonstrated the success of the treat-ment and the need for its control, but we had no idea of the high prevalence of edema in the...

Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"

... components by use of the inverse Diels Alder technology. The high chemical stability and the ease of synthesis qualify these polyamide building blocks as favourites for intracellular delivery and ... Germany. The synthesis of the Reppe Anhy-dride was carried out as documented by Reppe [16]. The reaction to tetracy-clo-[5.4.21,7.O2,6.O8,11]3,5-dioxo-4-aza-9,12-tridecadiene 4-yl acetyl ... 5-dansyl sulfamidoethylcarboxamide-2-yl. 4. For the syntheses of the polyamide-based pentamers I-III (Figure 3, Figure 4) and the heptamer (the ligation product 15 is shown in Figure 7) the...

Báo cáo y học: " Efficacy of the Valsalva Maneuver on Needle Projection Pain and Hemodynamic Responses During Spinal Puncture"

... to the third minutes after that were statistically different between the study groups (P= 0.016). Post Hoc Tukey test showed there was statistical difference in HR between the ball and the ... hemodynamic responses between the study groups. P<0.05 was considered statistically significant. Results There were no statistical differences in the de-mographic data between the study groups ... University of Medical Sciences from January to March 2010. The study pro-tocol conformed to the ethical guidelines of the 1989 Declaration of Helsinki. Ethics Statement To evaluate the effect...

Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"

... Synthesis of the PNA building block backbone In the next step, the synthesis of the PNA back-bone monomer using the fluorenylmethoxycarbonyl (Fmoc) protection occurred as described by Atherton ... Sheppard.[40] Synthesis of the Fmoc-C2-glycine-tert-butyl ester The synthesis of the peptide nucleic acid back-bone requires the introduction of protecting groups as shown in the Fmoc-C2-glycine-tert-butyl ... 5): shows the pentamer of the “Reppe anhydride” [(RE-PNA)5Cys] connected by the cysteine mediated disulfide formation with the CPP-Cys (displayed in amino acid single letter code). The ligation...

Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"

... pharmacokinetics are the drug transporters and the metabolizing en-zymes [7,9]. CYP3A, the primary subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of ... Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. CYP3A5 polymorphisms seem to affect tacrolimus kinetics at a greater degree com-pared to CYP3A4 ones and thereby, ... Results The characteristics of the study population are shown in Table 1. The frequency of CYP3A5*3/*3 genotype was 87.5% (35/40) whereas the frequency of the CYP3A5*1/*3 genotype was 12.5%...

Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"

... group was similar as the frequency of 0.21 reported by Chen et al. in their study for chd patients derived from the lipoprotein coronary atherosclerosis study. Conversely, Skogsberg et al. ... The frequency of the C-allele was 0.24 and the genotypes were distributed according to the Hardy Weinberg Equilibrium. Overall the C allele frequency was higher in patients with coronary ... was supervised by handing out a nutritional diary which was submitted at each of the further visits to the clinic. After 6 weeks the patients attended the clinic again and it is the lipid values...

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