... whereas
wild-type controls and mice lacking endothelial NO synthase
(eNOS
–/–
) presented with similar less pronounced
Commentary
Nitric oxide, leukocytes and microvascular permeability:
causality or bystanders?
Balázs ... sepsis-related microcirculatory failure,
and in this context leukocytes are thought to assume major
importance. However, the role of nitric oxide (NO) i...
... increased activity of NOS may
represent predominantly of nNOS isoform. In reper-
fusion group the activity may be attributed to iNOS
and nNOS and increased activity may be mainly by
iNOS due to ... conditions and were given normal diet for 5
days and decapitated and the different brain regions
(CC, CB and BS) were used for study. It was reported
by Ananth et al (23) that 5 da...
... pulmonary artery showing no immunocytochemical positivity for nNOS. (F)
Control patient small pulmonary artery showing no positivity by immunocytochemistry for nNOS. × 400.
Respiratory Research ... Pathology, Glasgow Royal Infirmary, Glasgow, UK and
4
Department of Physiology and
Pharmacology, University of Strathclyde, Glasgow, UK
Email: Thomas Hoehn* - thomas.hoehn@uni-duesseldorf.de...
... mM of NOR-1 for 30 min, 1, 3, 5 and
24 h or PKC inhibitors for 30 min. MUC5AC promoter
activity was determined by measuring luciferase activity
after the lysing the transfected cells and normalizing ... markedly increased the
MUC5AC promoter activity and mRNA expression, mucin synthesis and ERK1/2 phosphorylation. The PKC
inhibitors also inhibited the NOR-1 induced MUC5AC mRNA and...
... additional inflammatory
cytokines such as IL-1β and TNF-α are derived primarily
from macrophages (not Th1 or Th2-derived) and also play
Respiratory Research 2009, 10:3 http://respiratory-research.com/content/10/1/3
Page ... inflammation
describes an imbalance in the Th1 and Th2 lymphocyte
and cytokine profile. The former produce primarily IL-2
and IFN-γ, and are generally respon...
... pro-inflammatory actions by
other mechanisms. For instance, NO
•
can promote the
expression of pro-inflammatory cytokines or cyclo-oxyge-
nase (responsible for the formation of inflammatory
prostanoids) ... mediated by various
actions, either by NO
•
itself or by secondary RNS, and
the overall biochemistry of NO
•
is deceptively complex.
Moreover, the metabolism and chemistry of NO
•...
... medication (typical
vs atypical antipsychotic drugs).
For the total schizophrenic sample, PAS and SAS total
scores were significantly and positively correlated with
negative symptoms (SANS total score ... the 'core' def-
icits of schizophrenia. Today, it is still commonly
included by many authors [8-15] in the negative symp-
tomatology of schizophrenic disorders. For example,
An...
... admission and discharge may vary by
country. Controlling for symptoms and function scores,
this analysis indicated that patients in the US are more
likely to be admitted faster and also more likely to ... Symptomatology <75
Medium Symptomatology >
75 and <95
Highest Symptomatology >
95
Reference groups were lowest symptomatology for PANSS scores, high functioning for PSP s...
... 1
Glycolytic chain intermediary metabolism, glycerol and glycerophospholipid formation and the citric acid cycle. Simplified diagram of the
intermediary metabolism of the glycolytic chain and ... to hypoglycemia, reproduction, modulation of tau
phosphorylation, metabolism of amyloid precursor protein and
β-amyloid clearance, neuronal survival, and memory [9].
Since the observation b...
... lung injury
(ventilator-induced lung injury (VILI)) characterized by an
inflammatory response morphologically and histologically
indistinguishable from that caused by bacterial lipopolysac-
charide ... Jackson Laboratories (Bar Harbor, ME, USA)
and the National Laboratory Animal Center (Taipei, Taiwan).
Heterozygotes (+/-) are used because homozygotes exhibit
lower fertility and female...