Báo cáo y học: "Recently published papers: More about EGDT, experimental therapies and some inconvenient truths" potx

... ofbreathing a hydrogen oxygen atmosphere and half to nitrogenoxygen. The anti-inflammatory effects of the hydrogen werevery striking. The impracticality of repeating this study in anyclinical ... inmortality at 7, 14, 28 and 90 days, or indeed, serial sequentialorgan failure assessment (SOFA) score or a variety of haemo-dynamic end points. The study was prompted by limitedevidence, and a physiological ... mitochondrial therapies yet prove to be the therapies that end the optimalinopressor debate?Hydrogen?Staying in the realm of novel therapies, hydrogen may also bein ICUs in the future. My personal...

Báo cáo y học: "Recently published papers: of head injuries, high frequencies and haemodynamic optimization" pps

... mortality and transfusion. Vincent and colleagues used a propensity scoring system to identify twodistinct groups and control for confounders, and found anodds ratio of 1.37 for mortality in transfusion ... surgery, trauma and sepsis patients. Their findings confirmed further thatwhen therapy is aimed at improving oxygen delivery(especially in the severely ill, in whom control group mortalitywas ... nonrecipients. However, scrutinyreveals that the confidence intervals for this verge on unity,pointing out the problems of analysis with just so manyvariables. One day soon someone may take up the gauntletof...

Báo cáo y học: "Recently published papers: small pieces of the puzzle and the long-term view" pps

... phenomenon.ObesityAgainst the background of the global epidemic of obesity,the impact of body mass index on the short-term outcomes ofcritical illness has been investigated by Tremblay and Bandi[5]. ... illness polyneuropathyValuable long-term follow-up data from survivors of criticalillness who had spent more than 28 days in intensive carewere presented by Fletcher and colleagues [6]. Theyreported ... intensive care unit (ICU) stay of only 2 days. Fifty-sixper cent of patients admitted to ICU were overweight (30%),obese (20%) or severely obese (6%). Unsurprisingly, theinvestigators found...

Báo cáo y học: "Recently published papers: Renal replacement therapy: which route and how much? Intracerebral haematomas: does the size matter? β blockers and steroids: will we ever know" doc

... almost entirely based on the DECREASEseries [10] by Poldermans and colleagues, which were“mainly observational, done primarily only on vascular surgerypatients and in only one country in the world”. ... 7 days and 3.1% at 28 days afteradmission. Adjuvant corticosteroid therapy was not associatedwith reduced mortality in any age group. The hazard ratio (HR)for children younger than 1 year ... considered higher risk than patients in the POISE study.Steroids for meningitis and acute respiratorydistress syndromeThe study by Mongelluzzo and co-workers [11] aimed toevaluate the relationship...

Báo cáo y học: "Recently published papers: a little less ventilation, a little more oxygen please" pot

... diaphragmatic injury caused by mandatoryventilatory modes coupled with the sedation and sometimesneuromuscular blockade required to achieve them may wellhave been underestimated, to say nothing of ... patient,however, BNP is merely a marker of cardiac strain and isuniversally elevated in hyperdynamic and shocked patients,regardless of the aetiology.In this study, 41 patients who met a standard set of ... recruitment, themajority of patients had received many hours of ‘routine’mechanical ventilation prior to study entry, thus potentiallymissing the vital early effect of any strategy.Alongside these...

Báo cáo y học: " Recently published papers: Topical issues in pharmacology" pptx

... a more recent paper on the effects of methylprednisolone inunresolving acute respiratory distress syndrome [10], and may account for a therapeutic modality by which high-dosesteroid therapy ... Jr, Landry DW, Townsend RN: Low-dosevasopressin in the treatment of vasodilatory septic shock. JTrauma 1999, 47:699-703.6. Tsuneyoshi I, Yamada H, Kakihana Y, Nakamura M, Nakano Y, Boyle WA ... life-threatening and intractable hypotension in septic shock. Although suchreports are somewhat anecdotal, the results are promising fora condition that is known to carry a high mortality rate, and itmay...

Báo cáo y học: " Recently published papers: We are what we eat" pot

... recovery ofgastrointestinal motility may be effective salt and waterbalance. In a study by Lobo and colleagues [4], prompted byCommentaryRecently published papers: We are what we eat?LG ForniConsultant, ... recent study reported by Yap and coworkers [7]. They retrospectively studied more than1000 patients over an 18-month period, their hypothesisbeing that serum hypoalbuminaemia may be predictive ... ofmortality risk in the critically ill. This was no doubt triggeredby the Acute Physiology and Chronic Health Evaluation(APACHE) III as well as the study reported by McCluskey and colleagues...

Báo cáo y học: " Recently published papers: New evidence for old debates, new drugs and some timely reminders" pps

... reported by Weber and colleagues [22].Sadly, adoption of this technique, in the UK at least, awaitsthe deliberation of the government and judiciary.Finally, if you have been seduced by the attractive ... 2002, 166:1-2.3. Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R,Davies NA, Cooper CE, Singer M: Association between mito-chondrial dysfunction and severity and outcome of septicshock. ... thedermal tolerance and user acceptability of six alcohol-basedhand disinfectants for hygienic hand disinfection. J HospInfect 2002, 51:114-120.25. Laffey JG, Kavanagh BP: Hypocapnia. N Engl...

Báo cáo y học: "Recently published papers: A number of treatment controversies" pptx

... particularly by doctors. Which agent(s)should be used, and how much and how often? These areimportant questions but they are not easily answered.Anxiolysis, analgesia, amnesia and sedation ... measures wereemployed, including costing, quality of sedation,haemodynamic stability and time to extubation, among others.Unsurprisingly, the studies showed wide clinicalheterogeneity and this precluded ... widely accepted thatunbridled sedation, given with best of intentions, is harmful interms of ventilator and ICU days and consequently outcome, and that a sedation protocol including daily cessation...

Báo cáo y học: "Recently published papers: Changing practices in the modern intensive care unit" pps

... cancer.Perhaps the study that will attract most attention is that bySandham and coworkers [4]. This is an impressive randomizedtrial that compared goal-directed therapy guided by pulmonaryartery catheter ... of severe injury. Whatthe study does highlight is the fact that our knowledge ofcritical illness polyneuropathy and myopathy is scant. Thechallenge now is to try to identify risk factors for ... didreceive slightly more colloid than packed red cells. Also slightlyworrisome is that the overall numbers collected were not greatgiven the ten year period of study, which may reflect changesin...

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