... doi:10.1016/j.ijcard.2008.09.004.21. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P,Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, MatsuoH, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata ... pro-vides an antioxidant defense in humans against oxidant- andradical-caused aging and cancer: a hypothesis. Proc Natl AcadSci U S A 1981, 78:6858-6862.51. Sanchez-Lozada LG, Tapia E, Bautista-Garcia ... causal association between hyperuricemia and selected cardiovascular diseases. Simple causal diagrams on the associationbetween hyperuricemia and selected cardiovascular diseases. (a) Hyperuricemia...