Báo cáo y học: " The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion" potx
Báo cáo y học: " The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion" potx
... that this glycan protects the CD4BSagainst antibodies.Conclusion: The carbohydrate at position 386 is not essential for protein folding and function, but is involved in the protection of the CD4BS ... purposes)RetrovirologyOpen AccessResearch The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasionRogier W Sanders*1, ... thatcauses the increased sensitivity, but rather the lack of the carbohydrate. Interestingly, both the asparagine at posi-tion 386 and the attached glycan are contact sites for b12 on monomeric gp120...
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Báo cáo y học: "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro" pdf
... antagonist WIN62577 inhibited ASMC IL-13-induced proliferation and ASMCmigration in vitro and therefore may be a new therapeutic option in asthma.IntroductionAsthma is a chronic inflammatory disease ... activate the neurokinin(NK)-1 and NK-2 receptors, leading to potent effects on a irwaysmooth muscle tone and secretions, bronchial circulation, and inflammatory and immune cells [10]. Tachykinin ... mRNAexpression had be en demonstrated in the a irways of asthmapatients [12]. However, the role of neuro kinins in the asthmaticairway and ASMC is u nknown. Therefore, in the present study,we investigate...
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Báo cáo y học: "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro" potx
... antagonist WIN62577 inhibited ASMC IL-13-induced proliferation and ASMCmigration in vitro and therefore may be a new therapeutic option in asthma.IntroductionAsthma is a chronic inflammatory disease ... In this experiment, we demonstratedtha t NK-1R antagonist WIN62577 had the effect of inhi-biting ASMC migration in vitro, indicating thatWIN62577 may contribute to the inhibition of airwayremodeling. ... in the design of the study and performed the statistical analysis. BW participated in ASMC proliferation and migrationanalysis. All authors read and approved the final manuscript.Declaration...
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Tài liệu Báo cáo Y học: The effects of low pH on the properties of protochlorophyllide oxidoreductase and the organization of prolamellar bodies of maize (Zea mays) pot
... presented in Fig. 12B, is very similar to that for the photoconverted enzyme, indicating that it is the conform-ational changes that predominate in both cases. Minordifferences were seen in the rates ... shift in the absorption maximum of the photoconverted enzymeoccurring under these conditions to be inhibited by ATP and by the protein phosphatase inhibitor NaF. On the basisof this study, and subsequent ... which then destabilizes the cubic structure of the membrane. This reduced NADPHbinding capability of POR is reflected in the large disparity in the half-saturation concentration for the restoration...
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Báo cáo Y học: The porcine trophoblastic interferon-c, secreted by a polarized epithelium, has specific structural and biochemical properties potx
... potential glyco-sylation sites present on the IFN-c polypeptide core. Theycould differ in the rate and site of glycosylation, considering the 22 500-Da band as bi-glycosylated and the 18 000-Daband ... latterisoform being glycosylated on N16. As expected, the correspondance between the measured masses and observedMr in SDS/PAGE is quite good for nonglycosylatedproteins, but not for glycosylated ... modifications, includingglycosylation, are strongly dependant upon the type and physiological status of producing cells, and may signifi-cantly in uence the characteristics of a glycoprotein[16,17,29]....
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Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... gain new insight into the effect of the drug on the regulation of 5-LOX, one of the main enzymes involved in the synthesis of LTB4 by chondrocytes [4,24].Figure 2Cathepsin K gene expression ... localaction on chondrocytes and the synthesis of catabolic factors and, second, by being an important upregulating factor in the synthesis of IL-1β by OA synovium. This concept is also sup-ported by ... level and safranin-O staining,also strongly supporting the hypothesis of its role in OA.Licofelone treatment significantly inhibited the synthesis of the enzyme at the transcriptional level in...
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Báo cáo y học: "The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis" ppsx
... Arthri-tis Foundation, and by an Arthritis Foundation Clinical Sciences Grant. The study sponsor was not involved in study design, in the collection, analysis, and interpretation of data, in the ... design and coordination of the study,read the MRIs, and prepared the manuscript. YZ participated in the design of the study. JN performed the statistical analy-ses. JG participated in the sequence ... supine and non-weight-bearing, and in longitudinal evaluations.Competing interests The authors declare that they have no competing interests.Authors' contributionsLK participated in the...
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Báo cáo y học: "The impact of infliximab treatment on quality of life in patients with inflammatory rheumatic diseases" ppsx
... permitted in START as long asthey did not have conditions or concomitant medications thatwere prohibited by the product labeling.Data from the Ankylosing Spondylitis Study for the Evaluationof ... REMICADE Therapy (START) (n = 1083), the AnkylosingSpondylitis Study for the Evaluation of Recombinant InfliximabTherapy (ASSERT) (n = 279), and the Infliximab MultinationalPsoriatic Arthritis Clinical ... analysis of covariance; AS = ankylosing spondylitis; ASSERT = Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy; ATTRACT = Anti-TNF Trial in Rheumatoid Arthritis...
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Báo cáo y học: "The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients" pptx
... analysis showing canonical pathways of the 39 differentially expressed proteins after infliximab treatment in the responder group. The pathways are indicated on the y- axis. The x-axis indicates ... respondersIngenuity pathway analysis of proteins displaying alterations in expression patterns following infliximab treatment in patients deemed to be respond-ers. (See Results for response definitions.) The ... with these proteins.Figure 3Ingenuity pathway analysis showing canonical pathways of the 39 differentially expressed proteins after infliximab treatment in the responder groupIngenuity pathway...
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Báo cáo y học: "The effect of CpG-ODN on antigen presenting cells of the foal" ppt
... the observations with the top line indi-cating the upper quartile, the middle line showing the median value, and the lower line indicating the lowerquartile. The lines extending from the box ... tissues.Therefore, the combination of cell surface marker expres-sion, using the monoclonal antibodies available for the horse species, and the expression of cytokines upon stim-ulation may ... levels, the foal must rely on its immune system to resist infections. In addition, protection against intracellular pathogens mayrequire cellular immunity. Therefore, early maturation of the foal's...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM