Báo cáo y học: "Downregulation of CD94/NKG2A inhibitory receptors on cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts" doc
... purposes)
Retrovirology
Open Access
Short report
Downregulation of CD94/NKG2A inhibitory receptors on CD8
+
T
cells in HIV infection is more pronounced in subjects with detected
viral load than in their aviraemic ... controls. Within the HIV infected patients, the proportion of
CD8
+
T lymphocytes and NK cells expressing CD94/NKG2A was hig...
... migration in
hyp oxia-induced pulmonary hypertension. We hypothe-
sized that inhibition of systemic CXCR4 through admin-
istration of AMD3100 wi ll inhibit hypoxia-induced
pulmonary hypertension ... The hypothesis that CXCR4 is critical in hypoxic pulmonary hypertension in rats has been
demonstrated. The present study not only has shown an inhibitory effect caused by systemic in...
... for
p24
gag
. In contrast to the findings with HIV strain IIIb
infection of Jurkat T cells, Peptide 3 inhibited infection of
THP-1 cells by more than 80% (Fig 3c), very similar to the
effect of MIP1α. ... observations that BSCIs such as Peptide
3 do not block chemokine ligand interactions with their
receptors [27].
Effect of peptides on HIV infection in...
... Republic of Korea
2
Department of Biochemistry, Seoul National University College of Medicine, 28 Yongun-dong, Chongno-gu, Seoul, 110-799, Republic of Korea
Corresponding author: Yeong Wook Song, ysong@snu.ac.kr
Received: ... pro-apoptotic
role in RA FLSs.
Introduction
Rheumatoid arthritis (RA) is a chronic inflammatory disorder
that involves mainly joint synovium. One of the ma...
... from the study along with subjects
with a history of concurrent purulent nasal infection in
the six weeks before the study or any kind of nasal surgery
during the last year. None of the patients ... binding included nor-
mal rabbit serum without primary antibody and second-
ary antibody alone. Since cross-reactions with other
proteins containing amino acid sequences recogniz...
... production. Thus, prevention of PDI
downregulation in sepsis may be a novel approach to attenuate
hyperinflammation and to reduce tissue injury under such
conditions.
Introduction
Infection and sepsis ... Role of extracellular
molecular chaperones in the folding of oxidized proteins.
Refolding of colloidal thyroglobulin by protein disulfide iso-
merase and immunoglobulin heavy c...
... means
of the AxioVision image processing and analysis system
(Carl Zeiss Vision).
Flow cytometry
For each staining, 2 × 10
5
cells were incubated for 30 min
at 4°C with saturating concentrations ... localization
consistent with that of activated myofibroblasts. The
slightly diffuse staining is suggestive of extracellular
matrix deposition consistent with the expression of th...
... Malaysia
2. Faculty of Biotechnology, Malaysia University of Science and Technology, Petaling Jaya 47301, Malaysia
3. Discipline of Medicine, Blackburn Building D06, University of Sydney, NSW ... to verify two of the three co-infections
produced by the nested PCR technique through cloning
and sequencing but we only managed to obtain singular
genotypic infections for every each...
... acids
(e.g.
D
-Val,
D
-Ile,
D
-Leu,
D
-His, and
D
-Arg). GO is strictly
stereospecific as it only catalyses the oxidation of the
D
-isomer, as further demonstrated by the INT staining
assayreportedinFig.5,inset.
A comparison of t ... using GO. Interestingly,
D
-proline i s t he only amino acid in which the a-amino group
is involved in a covalent bond with the side chain and it i...
... five-
coordinated hemes in nitrosylhemoglobin: interpretation of
electron spin resonance spectra. Biochemistry 15, 4427–4428.
30. Perutz, M.F. (1979) Regulation of oxygen affinity of hemoglobin:
in uence ... HSA–haem is hexa-coordinated,
possibly being bonded to His105 and Tyr148 as suggested
by docking simulations [7]. Upon drug binding, neither a
change in the haem-iron atom coor...