Báo cáo y học: "Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo" doc

... boost HIV-1 spread in HIV-1- infected HLAC and identify two inde-pendent protein interaction motifs in Nef that facilitateCD4+ T lymphocyte depletion independently of theireffect on HIV-1 replication. Nef ... human lymphoid tissue: correlation of CD4+ T cell depletion and virus syncytium-inducing/non-syn-cytium-inducing phenotype in histocultures inoculated withlaboratory strains and patient isolates ... predominately in uninfected bystander CD4+ T cells.Conclusion: Our findings suggest that Nef facilitates depletion of CD4+ T lymphocytes in HIV-1- infected lymphoid tissue ex vivo by increasing...

Báo cáo y học: "BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance" ppt

... RA and PGIA suggest that certain as-yet-unknownalterations of the immune system exist in both humans and mice. As a continuation of the experiments presented in thisstudy, we are comparing ... colonies/substrains (for example, in body weight, size of littermates, and the composition of intestinal bacterial flora)maintained at different locations by the same vendor. Accord-ing to the online ... severe arthritis) still might be in the initiative (proinflammatory) phase of arthritis at the end of the experiments (days 63 and 64). This was supported bythe serum levels of autoantibodies to mouse...

Báo cáo y học: " Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone" pot

... apoptosis of phagocytes, resulting in either control of intracellulargrowth of the bacteria or evasion of the immune system[14]. Based on the results of the present study, it is difficultto tell ... by flow cytometryFigure 6Analysis of the nuclear DNA fragmentation in L. pneumophila-infected A549 cells by flow cytometry. Two days after treatment, A549 cells were treated for TUNEL staining ... and subsequently stimulated. After a 2-day incubation, nuclear DNA fragmentation stained by the TUNEL method was analyzed by flow cytometry. The nuclear DNA fragmentation of virulent strain...

Báo cáo y học: "Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats" doc

... assistants to carry out clinical chemistryassays. Both authors read and approved the final version of the manuscript.Competing interestsThe authors declare that they have no competing interests.Received: ... (5-HPETE), and subsequently into the epoxide intermediate leukotrieneA4 (LTA4). Hydrolysis of LTA4 by LTA4 hydrolaseleads to the formation of the potent neutrophil che-moattractant LTB4, whereas ... mediators of inflammation; thus, sup-pression of LT formation b y BA may be the underlyingmechanism of the anti-inflammatory actions of BA.Effect of BA administration on the antioxidant status in rats...

Báo cáo y học: " Spontaneous heterotopic pregnancy with tubal rupture: a case report and review of the literature" pptx

... presence of intrauterine pregnancy, canbe an important aid in the diagnosis of HP [1]. Further,visualization of heart activity in both intrauterine and extrauterine gestation confirms the diagnosis ... condition of the patient. The main aim of the surgery should be thepreservation of the intrauterine pregnancy with minimalmanipulation of the uterus. Medical treatment for ectopicpregnancy with ... laparotomy [1]. One of the reasons for thisunexpected observation is that HP is a rare condition and most patients with HP present in the emergency depart-ment with symptoms of a rupture of ectopic...

Báo cáo y học: "Group cognitive behavioural therapy for women with depression: pilot and feasibility study for a randomised controlled trial using mixed meth" pptx

... recruits at the firststage were due to delays in GP pract ices sending lettersout after the notes searches, the short time window of intensive recruitment and that fact th at the start date of the ... intervention and conduct of the trial.Feasibility of recruitmentRecruitment into trials for mental health interventions isnotoriously difficult [26]. Gaining interest in this studywas not problematic; ... about theirinterest in this kind of interventi on. With hindsight per-haps a bigger effort to explain in greater detail the type of treatment might have helped to reduce initial dropouts aswell...

Báo cáo y học: " Myocardial infarction with normal coronary arteries: a case report and review of the literature" pps

... risk profile of the patient at the time of acute MI,the absence of symptoms after the event and the absence of inducible ischaemia during the treadmill exercise test and decided that a non-invasive ... report and accompanyingimages. A copy of the written consent is available for review by the Editor -in- Chief of this journal.Competing interestsThe authors declare that they have no competing interests.Authors' ... prepared a CTangiography protocol to study in a single-setting coronary and whole-body arterial system. CC analyzed and inter-preted the imaging studies. All authors read and approvedthe final manuscript.AcknowledgementsThe...

Báo cáo y học: "Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions" doc

... that the two main techniquesused to detect protein-protein interactions, namely yeast two-hybrid and affinity-purification-coupled mass spectrometryare of high quality and of complementary ... use in further experimental investigation. Finally, wewere also able to estimate the extent of interlocking betweenother major regulatory systems such as transcription and theubiquitin system ... first, the ubiquitination datasets donot distinguish between the predominantly destabilizing K48polyubiquitination on the one hand and the K63 polyubiqui-tination and monoubiquitination on the...

Tài liệu Báo cáo khoa học: "A Mobile Touchable Application for Online Topic Graph Extraction and Exploration of Web Content" ppt

... the content of a topic or to interactivelyexpand a topic with newly computed relatedtopics. In the ﬁrst step, the topic graph is computed onthe y from the a set of web snippets that has beencollected ... actuallylabeled with the speciﬁc relation that exists betweenthe nodes. In this way the user can explore in an uniform wayboth new information nuggets and validated back-ground information ... it comes to in- teresting and suprising facts users enjoyed exploringthe results using the topic graph. The overall feelingwas in favor of our system which might also be dueto the fact that...

Báo cáo khoa học: "A Cascaded Linear Model for Joint Chinese Word Segmentation and Part-of-Speech Tagging" pdf

... forbidden except the designated train-ing corpus. In order to test the performance of thelexical-target templates and meanwhile determinethe best iterations over the training corpus, we ran-domly ... and multi-character word respectively. In order to performPOS tagging at the same time, we expand boundarytags to include POS information by attaching a POSto the tail of a boundary tag as ... thereare two strategies to choose: performing POS tag-ging following segmentation; or joint segmentation and POS tagging (Joint S& ;T) . Since the typical ap-proach of discriminative models treats...

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