Báo cáo y học: "Activation and detection of HTLV-I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat model" pptx
Báo cáo y học: "Activation and detection of HTLV-I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat model" pptx
... AccessResearchActivation and detection of HTLV -I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat modelTakashi Ohashi*, Mika Nagai, Hiroyuki Okada, Ryo Takayanagi ... Ohashi T, Hanabuchi S, Kato H, Koya Y, Takemura F, Hirokawa K,Yoshiki T, Tanaka Y, Fujii M, Kannagi M: Induction of adult T-cellleukemia-like lymphoproliferative disease and its inhibition by ... 236:1103-1106.8. Nishioka K, Maruyama I, Sato K, Kitajima I, Nakajima Y, Osame M:Chronic inflammatory arthropathy associated with HTLV -I. Lancet 1989, 1:441.9. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K,...
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Báo cáo y học: "Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes" pptx
... growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta. Arthritis Rheum ... publications that FGF-2 stimulates catabolism and/ or anti-anabolism by inducing cartilage degrading enzymes (e.g., MMP1, MMP13) and proteoglycan loss in articular cartilage in vitro and ex vivo ... cartilage to its original pristine hyaline state, due to multiple impairing mechanisms [5-8]. FGF-2 participates in the regulation of cartilage homeostasis in addition to its well-established...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... patients and controlindividuals, and examined whether TGF-β1 activation wasassociated with clinical phenotype, in particular inflammatorydisease activity, cumulative organ damage and earlyatherosclerosis.Materials ... SLE patients and control individuals withinthe context of inflammatory disease activity, cumulative organdamage and early atherosclerosis. An Activation Index (AI) forTGF-β1 was determined ... confidence interval0.84–1.00).Statistical analysisTGF-β1 activation indices and lymphocyte apoptosis in SLEpatients and control individuals were compared using theMann-Whitney U test. Clinical associations...
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Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury" potx
... appear to have repair capacity in animals and humans, especially in young individuals [2,3,5-8]. Repair of full thickness JSDs involves coordination of pat-terning and tissue maturation that ... and injured (B) articular cartilage 6 days after the operation. The asterisk indicates the site of injury (occupied by debris). The dashed line indicates the margin of the injury site.Available ... artic-ular cartilage is capable of triggering a signaling machinerythat may play a role in joint surface repair.Although several risk factors for OA have been identified,including the nature...
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Báo cáo y học: "Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis" pot
... 3Profiling gelatinase gene expression and gelatinolytic activity in resorbing cartilageProfiling gelatinase gene expression and gelatinolytic activity in resorbing cartilage. Bovine nasal cartilage ... 37°C, and one unit of inhibitory activity inhibits twounits of collagenase by 50%. Gelatinase activity in the culturesupernatants was assayed by gelatin zymography. SamplesOpen AccessAvailable ... expression, collagenase activity, and collagenolysis in resorbing cartilageProfiling collagenase gene expression, collagenase activity, and collagenolysis in resorbing cartilage. Bovine nasal cartilage...
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Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... participated in study design, acquisition of data, analysis and interpretation of data, statistical analysis, and manuscriptpreparation. NA participated in acquisition of data, analysis and interpretation ... interpretation of data, statistical analysis, and manuscriptpreparation. JMP and JPP participated in study design, analy-sis and interpretation of data, and manuscript preparation. NDparticipated in ... catabolic and inflammatorypathways that take place during OA by inducing the synthesis of major catabolic and inflammatory mediators via the p38 and p42/44 signalling pathways. Furthermore, PAR-2...
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Báo cáo y học: " Global and unbiased detection of splice junctions from RNA-seq data" pptx
... detection of expression levels and coding-sequence variation in a single analysis pipeline will be beneficial for patient-sample analysis. We have implemented our method in a software called SplitSeek. ... genefusionsinanRNAsampleinacompletelyunbiasedway. We also want to emphasize the possibility of find-ing insertions, deletions, and o ther types of geneticrearrangements with the SplitSeek approach. ... can perform othertypesofanalysisinwhichRNA-MATEorotheravailable tools cannot be directly applied. These inc ludeidentification of splice sites in uncharacterized tran-scripts, detection of...
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Báo cáo y học: "Activation of monocytes and cytokine production in patients with peripheral atherosclerosis obliterans" docx
... of 7Plasma levels of pro and anti-inflammatory cytokinesPlasma levels of IL-6, TNF -a and IFN-g were significantlyhigher in patients; t he levels of the anti-infl ammatorycytokines IL-10 and ... plasma levels of anti-inflammatory and inflammatory cytokines including interleukin-6 (IL-6), IFN-g, IL-10 and transforming growth factor-beta(TGF-b) in p atients with peripheral arteriosclerosisobliterans, ... 7Plasma levels of this cytokine are higher in patients withcoronary diseases such as stable and unstable angina, and myocarditis [22]. The primary function of this cytokine isto activate monocytes/macrophages...
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Báo cáo y học: "Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)" docx
... Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, USAEmail: Jia Hai ... study and wrote the manuscript.AcknowledgementsWork in Kuan-Teh Jeang's laboratory is supported in part by intramural funding from NIAID, NIH; and by the intramural AIDS targeted antiviral ... affects multiple cellular pathways in most, if not all, cells. Accordingly, cGMP-influenced path-ways are likely to interdigitate with some of the signalingroutes utilized by HIV-1 in infected...
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Báo cáo y học: " Construction and analysis of a modular model of caspase activation in apoptosis" pot
... assembly by Nakabayashi and Sasaki [75] at the parameter values considered in thisstudy exhibits a characteristic time delay on the order of 100 min. A simple improvement is the delayed initiation of ... Furthermore, as implicated by thesynthesis rate of its inactive form, Smac*, and correspond-ingly its target XIAP, plays a vital role in achieving thecorrect activation level, which in particular illustrates ... eliminate reactions nearsaturation; however these cases should intuitively betreatable analytic ally. Moreover, the implementation of a faithful model exhibiting bistability is of primarybiological...
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