... period. Tissue preparationThe sham and the CLP mice were re-anaesthetized and placed on a heating pad, and core temperature was monitoredusing a thermocouple rectal probe and maintained between36°C ... ketamine/xylazine 80:10mg/kg via intraperitoneal injection. Sepsis was induced bycecal ligation and perforation (CLP). An incision was madealong the linea alba. The cecum was mobilized and gently ... variety of tissues in the cardi-ovascular system, including cardiomyocytes, vascular smooth muscle, and endothelial cells, and has been shown to mediateanti-apoptotic, anti-inflammatory, and endothelial...