... [4,6,8,9]. There is an
increasing body of evidence that activated protein C (APC)
exerts beneficial effects in the microcirculation. Human
plasma-derived and human cell-produced recombinant protein
C inhibits ... biologic activities of APC, besides the inhi-
bition on coagulation, which may affect the microcirculation.
Important actions of APC are also the profibrinolytic...
... expression and pro-inflammatory cytokines via the
induction of protease activated receptor-1. Inadequate bind-
ing of aPC to EPCR could explain the absence of the anti-
inflammatory effect and be responsible ... coli infusion in the baboon. J Clin Invest 1987,
79:918-925.
23. Roback MG, Stack AM, Thompson C, Brugnara C, Schwartz HP,
Saladino RA: Activated protein C concentrate...
... and indi-
viduals with protein C deficiency suggesting that the circu-
lating protein C concentration is the limiting factor in the
rate of activation of protein C [33]. Therefore, protein C
levels ... a critical step in
the host defence against sepsis since inhibition of protein
C binding to EPCR (in baboon model) is shown to con-
vert the response to suble...
... against [9,10], and as such, the results of this
study are of interest.
The need for assessment of clinical and economic outcomes
after the introduction of a novel therapeutic agent is
increasingly ... appears there is a role for generation
of new clinical evidence.
Costs in their study were collected using microcosting
methods, which are regarded as the most valid means of
measurin...
... from Charles River
(Maastricht, the Netherlands) and maintained in the ani-
mal facility of the Academic Medical Center (University
of Amsterdam) according to national guidelines with free
access ... Blick KE:
Protein C prevents the coagulopathic and lethal effects of Escherichia
coli infusion in the baboon. J Clin Invest 1987, 79:918-925.
29. Bajzar L, Nesheim ME, Tracy PB...
... In the present issue of Critical Care, Pettila and colleagues
report the fi rst single-centred pilot randomized
controlled trial of activated protein C (APC) in alcohol-
induced acute pancreatitis ... erence in bleeding complications, yet serious bleeding
is actually a relatively infrequent event in patients treated
with APC. In a meta-analysis of 10,679 APC-treated
pati...
... analyzing the data and interpreting the results, revising the manuscript,
and approving the manuscript in its final form.
Competing interests
The authors declare that they have no competing interests.
Received: ... Physicians; Canadian Critical Care Society;
European Society of Clinical Microbiology and Infectious Diseases; European
Society of Intensive Care Medicine, et al: Survi...
... role in PEDV attachment and entry in the muscle cells
of experimental animals. Thus, the increased entry of PEDV
into the muscle cells might induce higher antibody
production against PEDV when compared ... presenting cells in
experimental animals. In addition, as molecular mechanisms
of dendritic cell-induced T cell activation, pAPN appeared
to be involved in activation of...