Báo cáo y học: "Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1" ppsx
Báo cáo y học: "Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1" ppsx
... Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. Retrovirology2011 8:36.Submit your next manuscript to BioMed Centraland take full advantage of: ... in miRNA profile is observed by ablation of Vpr/VifThe possibility that HIV-1 manipulation of host miRNA contributes to HIV-1 induced cell cycle delaywas posited by the prominent role of miRNA ... 13RESEARCH Open AccessTat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1Amy M Hayes1, Shuiming Qian1,2, Lianbo Yu3and Kathleen Boris-Lawrie1,2*AbstractBackground:...
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Báo cáo y học: "Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65" pptx
... deviation of thecytokine response, caused either by decreased Th1-typecytokines and/or by enhanced Th2-type cytokines leading to the regression of an autoimmune disease, is reminiscent of other ... secretion of the anti-inflammatory cytokine IL-10over the pro-inflammatory cytokine IFN-γ, resulting in the over-all skewing (immune deviation) of the cytokine response to ananti-inflammatory type ... thereby, induced a relative skewing(immune deviation) of the cytokine response towards a pre-dominantly anti-inflammatory type.Celastrus-fed LEW rats reveal enhanced antibody response to Bhsp65LEW...
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Báo cáo y học: "Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat" pps
... and MTX were found to inhibitfunction of phagocytic cells and both monocytic/lymphocyticproinflammatory cytokines involved in rheumatoid synovitis,and this seems to be the key role in the sustained ... alleviate the symptoms and improve the quality of life. Thenonsteroidal anti-inflammatory drugs and glucocorticoids arelargely used for treatment of rheumatoid arthritis in spite of their systemic, ... treatment of osteoarthritis. Drugs 1996, 52(Suppl 3):27-38.21. Firestein GS: Etiology and pathogenesis of rheumatoid arthri-tis. In Kelley's Textbook of Rheumatology Volume 2. Edited by: Ruddy...
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Báo cáo y học: "Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cell" ppsx
... intravenously or intracraniall y before and after the onset of motor functio n loss. Motorfunction of mice was evaluated by an accelerating protocol of rotarod test every 8 weeks. Immunohistochemical ... the toxicity of theprotein, influencing downstream pathways activated by the mutant protein and transplantation [4]. For symp-tom treatment, levodopa is temporarily useful for rigid-ity/bradykinesia ... or four times intravenously(Figure 1B). Motor function of mice was evaluated by anacceleratng protocol of rotarod test every 8 weeks.Latency to fall on rotarod test of SCA2 transgenic micewhich...
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Báo cáo hóa học: " Research Article Nonexpansive Matrices with Applications to Solutions of Linear Systems by Fixed Point Iterations Teck-Cheong Lim" docx
... eigenvalue of B.Let0 <μ<1 be fixed. Startingwith an initial vector x0, define xk ,y k,k 0, 1, 2, ,recursively by y 0 x0,QxkQ − A y k−1 b, y k y k−11 ... consistent, then y k,k 0, 1, 2, ,converges to a solution vector z of Ax b with rate of convergence given by y k− z oζk, 30where ζ is any number satisfyingmaxμ ... initial vector x0,let y 0 x0,QxkQ − A y k−1 b, y k y k−11 − μxk.48If Ax b is consistent, then y k,k 0, 1, 2, ,converges to a solution vector z of Ax...
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báo cáo khoa học: "Prenatal and postnatal correlated responses in maternal traits of mice assessed by crossfostering" ppsx
... genetic by number reared, postnatal maternal by number rearedor prenatal genetic by postnatal maternal by number reared effects. Interactions thatwere significant generally were ... oxidativephosphorylation, they are a prime candidate for cytoplasmic maternal effects contri-buting to selection response. Maternal effects associated with selection of maternallytransmitted ... congenitallytransmitted virus from dam to offspring can modify selection response in poultry.Further studies are needed to determine the importance of cytoplasmically trans-mitted...
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Báo cáo y học: " Ubiquitous RNA-dependent RNA polymerase and gene silencing" pptx
... site of introduction of the dsRNA. This spread depends on the activity of an RNA- dependent RNA polymerase (RdRP), which amplifies dsRNA to produce more copies, which are then cleaved by the ... role of these small RNAs is as a defense against transposable elements. The terminal structure of piRNAs is not like that produced by Dicer [19] and so they are likely to be produced by a Dicer-independent ... connection to RNAi given the central role of Dicer-2 in producing siRNAs. The levels of certain microRNAs were assayed in Elp1-depleted cells and found not to be affected, indicating a specificity of...
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Báo cáo y học: " Selective gene silencing by viral delivery of short hairpin RNA" ppsx
... connected by a loop of unpaired nucleotides. MiRNA stem loopsare typically expressed as part of larger primary tran-scripts (pri-miRNAs) [44]. Artificial miRNAs more natu-rally resemble endogenous RNAi ... consisting of RNAse III enzyme Drosha and the double-stranded RNA- binding protein DGCR 8 into pre-miRNAs. These areexported from the nucleus into the cytoplasm by exportin-5. In the cytoplasm ... Selective gene silencing by RNAi can be achieved essentially by two nucleic acid based methods: i) cytoplasmic delivery of short double-stranded (ds) interfering RNA oligonucleotides (siRNA), where...
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Báo cáo y học: "Allele dependent silencing of COL1A2 using small interfering RNAs"
... previously by Millington-Ward (14) who reported allele-preferential silencing of COL1A1 in COS7 cells and in primary human mesenchymal progenitor cells. The results reported by Milling-ton-Ward ... 365vectors expressing short hairpin RNAs (shRNAs). Aptamer-shRNA chimaeras (18) may also be an inter-esting possibility to explore in order to deliver siRNAs specifically to certain cell types. ... par-tially complementary to the siRNAs, which will need to be further analyzed in order to exclude deleterious off-target effects. Another challenge will be to deter-mine how to administer siRNAs...
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Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot
... machinery [16] may promote thedevelopment of autoimmunity.ConclusionThe identification of components of the RNAi machinery astargets of the anti-Su autoantibody system provides anotherexample of ... death, either by apoptosis or(secondary) necrosis. Especially during programmed celldeath, key regulators of gene expression are inactivated by proteolytic cleavage or other types of modifications ... forRNAi in mammals, which is indeed supported by theproduction of suppressors of RNAi by mammalian viruses[15]. Based upon these phenomena and additional evidencefor the linkage of RNAi to...
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