Báo cáo y học: "A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins" ppsx
... structural constraint for functional interaction
between N-terminal and C-terminal domains in
simian immunodeficiency virus capsid proteins
Natsuko Inagaki
1
, Hiroaki Takeuchi
1
, Masaru Yokoyama
2
, ... Here, by
comparing two pathogenic SIV strains, SIVmac239 and SIVsmE543-3, we found critical amino acid residues for
functional interaction between the...
... phenotypic values for traits y and z can be structured in
terms of
φ
y
,
φ
z
,
ψ
y
,
ψ
z
and Σ
ε
(t) by a bivariate SAD(1)
model [15,16]. Also, the closed forms for the determinant
and inverse ... for circadian rhythms. In a mapping study of
196 F
2
hybrid mice, Shimomura et al. [24] detected 14
interacting QTL that contribute to the variation of rhyth-
mic behavior...
... fatigue, hyperexcitability,
insomnia, and increased appetite for approximately 20
days. Her HIV-1 infection was treated daily with the fixed
dose combination of 200 mg emtricitabine and 300 mg
tenofovir ... Cushing's syndrome and secondary adrenal insuffi-
ciency after a single intra-articular administration of
triamcinolone acetonide in HIV-infected patients treated
with riton...
... initial rolling and tethering interactions between circulat-
ing granulocytes, monocytes, and lymphocytes to endothelial
cells at sites of tissue injury [138,142]. P-selectin glycopro-
tein ligand-1 ... tissue injury.
Functional interrelationships between
clotting and the innate immune response
The close ancestral and functional linkage between clotting
and inflammation is...
... (2001) The
C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin)
is critical for maintaining its stable association with F-actin and is
implicated in the second actin-binding site. J. ... of the cofilin–G-actin interaction
We then tested for a pH dependence in the interaction of
cofilin with G-actin by two independent methods. G-actin
was labeled with RITC and increa...
... in part mediated by a portion of
the N-terminal region in vicinity of the a-crystallin
domain.
To ensure that efficient dimerization requires solely
a-crystallin domain and N-terminal region and ... with aA-crystallin and Hsp27 [45] indicate
that the dimeric building block of many a-Hsp proteins is
formed by interacting bstrands in the a-crystallin domain.
Although this may als...
... significantly inhibited IP-10 induction.
These results suggest that IP-10 expression within inflamed
joints appears to be regulated not only by inflammatory
cytokines but also by the physical interaction ... contami-
nating lymphocytes as a major source of IP-10 in the
FLS–monocyte interactions. We examined the effect of
mononuclear lymphocytes on IP-10 secretion in FLS lym-
phocytes. S...
... proinflammatory
cytokines TNF-α and IL-6 was increased. These findings
suggest that impairment of immune tolerance by increased T-
cell reactivity does not lead to enhanced susceptibility to CIA
and point ... disease by destroying target tissues through
induction of apoptosis of chondrocytes [33]. Alternatively,
Fas could contribute to synovial hyperplasia by inducing
proliferation of Fas...
... [http://genome.ucsc.edu/
]
10. Online Mendelian Inheritance in Man, OMIM™. McKusick-Nath-
ans Institute for Genetic Medicine, Johns Hopkins University
(Baltimore, MD) and National Center for Biotechnology Infor-
mation, ... QTLs in rat were obtained from the RatMap database [7].
These data were originally collected from experimentally
induced inflammatory arthritis in rat strains...
... Turpaz Y: Ploidy status and copy
number aberrations in primary glioblastomas defined by integrated
analysis of allelic ratios, signal ratios and loss of heterozygosity using
500K SNP Mapping Arrays. ... providing the cell line data for HL-60 and HT-29. CY is funded
by a UK Medical Research Council Specialist Training Fellowship in
Biomedical Informatics (Reference No. G0701810)...