Báo cáo y học: "Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5a-mediated restriction" docx

... H, Nakayama EE, Yokoyama M, Sato H, Levy JA, Shioda T: A singleamino acid of the human immunodeficiency virus type 2 capsid affectsits replication in the presence of cynomolgus monkey and humanTRIM5alphas. ... restriction factors in monkey cells arespecified by distinct regions of the human immunodeficiency virus type1 capsid. J Virol 2004, 78:5423-5437.63. Lin TY, Emerman M: Determinants of cyclophilin A-dependent ... Retrovirology 2010, 7:72http://www.retrovirology.com/content/7/1/72Page 12 of 13RESEA R C H Open AccessMultiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to...

Báo cáo y học: " Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates" ppt

... results further suggest that early dimerization of the PR and RT domains may serve as a regulatory element to influence the kinetics of processing within the Pol domain.Findings The retroviral ... sequence to the viral Gag-Pro-Pol polyprotein precursor [23,27] (Fig. 1A). Intrinsicprotease activity was inactivated by a D25A substitution of the catalytic aspartate of the PR domain to produce the final ... RT/RH site, suggesting that the RT domain in Gag-Pro-Pol was in a dimeric form under these assayconditions. These results clarify our understanding of the processing kinetics of the Gag-Pro-Polprecursor...

Báo cáo y học: "Physical anhedonia in the acute phase of schizophrenia" doc

... patients using the RPAS and the AIMS, the second using the PANSS and the EPSE and the third using the BARS. Information from the patient's his-tory, concerning social-demographic and clinical ... independent to depression, to general psychopathology symptoms ormotor side-effects induced by antipsychotic agents.Regarding the relationship of physical anhedonia andnegative symptoms the results ... to general psychopathol-ogy symptoms, estimated by both the PANSS and the BPRS.We did not find any studies exploring the the relationshipbetween physical anhedonia and motor side effectsinduced...

Báo cáo y học: "Folk medicine in the northern coast of Colombia: an overview" pptx

... (villages of fleeing slaves, or cimarrones) in the northern coast of Colombia, b eginning in the fif-teenth century. Much later, the term palenque becamesynonymous with freedom. From the many palenques ... heads of family were inter-viewed in 8 small towns of the northern department of Bolívar. Many of the interviews were accompanied bysupplemental information with specific details of the sp ... corresponding data onmorbidity given by the Office of Health of the depart-ment of Bolívar for the years 2006-2008 [25,26]. The parts of the plant most used for m edicinal pur-poses were, in decreasing...

Báo cáo y học: " Transcriptional control in the prereplicative phase of T4 development" pot

... termination and increased mRNA stabi-lity by RNA-binding proteins are involved in the regu-lation of gene expression in eukaryotes and theirviruses [135,136]. A thorough investigation of theseprocesses ... Thus, further work is needed to clarify the role of the of AsiA C-terminal region. Finally, very recent workhas shown that the inability of T4 motA mutants to plate on the TabG strain arises from ... [86]. In fact, expression of severalearly genes increase in the T4 motA- infection, presum-ably because of a delay in the shift from early to middletranscription [87]. MotA is a basic protein of...

Báo cáo y học: " Health status in the TORCH study of COPD: treatment efficacy and other determinants of change" pps

... [9,10]. In view of the pivotal nat-ure of these studies, it is important to understand the nature of these improvements and factors that mayinfluence them. We have used data from the TORCHtrial to ... particu-larly the Symptoms domain, which may continue forove r 3 months [14 ]. In TORCH, patients were excludedonly if they had an exacerbation requiring treatmentduring the 2-week run -in period, so the ... scores by visit for the total and the domain scoresare shown in Figure 1. The pattern of change in the pla-cebo arm differed between domains: the improvement in Symptoms score over the first...

Báo cáo y học: " Ethnic differences in the adaptation rate of HIV gp120 from a vaccine trial" ppsx

... correction in HYPHY [14]. In the latter case, we took recombinationinto account by first detecting recombination breakpointswith GARD [15], and then estimating the dN/dS ratiosindependently for ... that the rate of virus evolution is greater in this group than in othervolunteers. Differences in immune response to HIV-1infection have been pointed out by the rgp120 HIV Vac-cine Study Group ... Vaccine Study Group: Placebo controlled phase 3trial of a recombinant glycoprotein 120 vaccine to preventHIV-1 infection. rgp120 HIV Vaccine Study Group. J Infect Dis2005, 191:654-665.4. Eggink...

Báo cáo y học: "Programme costs in the economic evaluation of health interventions" docx

... by ana-lysts to suit the particularities of their own setting. In adapting these tools, analysts have to assess if the assumptions outlined in this paper are appropriate fortheir own setting. ... programme covering 95% of the population. However, as shown in Table 2, the domesticmargin is a minor cost compared to the cost of initiallytransporting a good to the country.Impact on resource ... costs vary considerably acrossinterventions and across regions, and that they can contribute substantially to the overall costs of interventions.IntroductionEstimating the costs of health interventions...

Báo cáo y học: "Saponin accumulation in the seedling root of Panax notoginseng" potx

... germination (the following May).After one month, all these five saponins were detected in the root. Then, with the growth of seedling, the sapo-nin contents increased rapidly in the root. The accumu-lation ... [11].Allthesefindingssuggestthatsaponinsmaynotserveas the nutrient storage in the seed. The protective func-tions of saponins in other plants are reported [13,14]. The role of this kind of secondary ... notdetected in P. notoginseng seed. The formation of sapo-nins in root is a gradual process. The synthesis andaccumulation of saponins began after germination andcontinued with the growth of seedling....

Báo cáo y học: "Oncoming tides in the Age(ing) of Aquarius" pps

... admitting very elderly patients to the ICU. Despite the apparent increase in demand for, and provision of critical careservices to, the elderly, there are few data on the outcomes from these ... likely to be discharged to a rehabilitation or long-term care facility, as opposed to living independently in the community. Several factorsincreased the odds of death among patients 80 years ... patients to the intensive care unit (ICU). Whetherexplicitly acknowledged or not, intensivists routinely debate (bothinwardly and outwardly) the benefit, utility, and patient-focuseddignity of admitting...

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