Báo cáo y học: "Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis." potx

... Human bile salt-stimulated lipase has a high frequency of size variation due to a hypervariable region in exon 11 Susanne Lindquist1, Lars BlaÈ ckberg2and Olle Hernell1Departments of 1Clinical ... protein is, however,abundantly glycosylated and the apparent molecular masson SDS/PAGE has been estimated to 120±140 kDa [11, 12]. Human BSSL has a unique primary structure ascompared to other ... fetal pancreas and in pancreatic tumoralcell lines [35,36]. FAPP and BSSL are structurally closelyrelated, but are distinguished by a monoclonal antibodydirected towards a fucosylated epitope,...

... Immunology, Volume 4, Number 3, 2008 ORIGINAL ARTICLE Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T -Cell and Dendritic Cell Immune ResponsesXiaoyuan Kong, MD, Gary R. ... Chitosan Interferon-c Nanogene Therapy for Lung Disease 99 be partially inactivated by CIN treatment, and theircapacity to activate T cells may consequently be reduced.Survival of mature dendritic ... altering cytokine production of aCD8+ T -cell subpopulation and by decreasing the antigen-presenting activity of dendritic cells.Figure 3. Effect of chitosan interferon-c nanogene (CIN) therapy on...

... Open Access Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuationMagali Naville, Daniel Gautheret*AbstractBackground: Bacterial transcription attenuation ... physical location, amongEnterobacteria supports an exaptation scenario, possiblyas an attenuator system. A second la rge attenuator clus-ter involving the genes artJ, ygdL, yhfZ and yijO wasalso ... article as: Naville and Gautheret: Premature terminator analysis sheds light on a hidde n world of bacterial transcriptional attenuation.Genome Biology 2010 11:R97.Submit your next manuscript...

... headache,back pain and generalized arthralgia/myalgia. There was a particularly troubling bone pain involving his forearms,wrists and hands bilaterally. The arm pain was unpredict-able, episodic and intense ... 1 of 4(page number not for citation purposes)Journal of Medical Case ReportsOpen Access Case report The boy who refused an IV: a case report of subcutaneous clodronate for bone pain in a child ... subcutaneous clodronate to treat malignancy-related bone pain in a child. Pain is a significant problem in children with cancer, and treatingit poses several challenges. One challenge for clinicianstreating...

... Psychological Treatment,Psychology Faculty, University of Malaga, Campus de Teatinos s/n. Malaga,29071 Malaga, Spain.2Department of Basic Psychology, University of Malaga,Malaga, Spain.3Department ... jmsalguero@uma.es1Department of Personality, Evaluation and Psychological Treatment,Psychology Faculty, University of Malaga, Campus de Teatinos s/n. Malaga,29071 Malaga, SpainFull list of ... Pablo Fernández-Berrocal2, Itziar Iruarrizaga3, Antonio Cano-Vindel3 and Sandro Galea4AbstractBackground: Terrorist attacks are traumatic events that may result in a wide range of psychological...

... hyperresponsiveness (AHR) is a functional abnor-mality characteristic of bronchial asthma [1]. AHR in asthma is defined as an exaggerated response of the airway (lower airway in particular) to a variety of nonspecificstimuli, ... explanation may be thatinhalation exposure includes nasal and gastro-intestinaluptake by Penh measurements. Penh may pick up allsources of resistance, upper airway as well as lower airway, and ... the increased airway resistance may be derived fromboth upper and lower airway. The invasive measurementis specific in measuring lower airway resistance.AbbreviationsAHR: Airway hyperresponsiveness;...

... between delta-SOFA and delayed initiation of adequate antibiotic therapyCorrelation between delta-SOFA and delayed initiation of adequate antibiotic therapy. SOFA, Sequential Organ Failure Assessment. ... shock and were excluded from this analy-sis). The rate of impairment in inflammatory response was sig-nificantly greater in patients with inadequate empirical antibiotic therapy than in patients ... sepsis. Polymorphisms in these genes may determine the concentrations of proinflam-matory and anti-inflammatory cytokines, and may influencewhether patients have a marked hyper-inflammatory or...

... (1.1)Values are expressed as mean ± standard deviation/median (interquartile range). a Peak and mean urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations were not statistically ... bypRIFLEmax strata and Figure 2 illustrates the data graphically.There was a statistically significant association between wors-ening pRIFLEmax status and increasing mean and peakuNGAL concentrations ... 6267888380801.5545697927384AKI, acute kidney injury; uNGAL, urine neutrophil gelatinase-associated lipocalin. Table 5Peak and mean uNGAL concentrations in survivors and nonsurvivors, by pRIFLEmax AKI strataMeasurement...

... this article as: Lee et al.: Using Guasha to treat musculoskeletal pain: A systematic review of controlled clinical trials. Chinese Medicine 20105:5.Publish with BioMed Central and every scientist ... trials that compared one type of Guasha withanother. Trials with Guasha as a part of a complexintervention were also excluded. No language restric-tions were imposed.Data extraction and quality ... RCTs of Guasha on pain management shouldadhere to accepted standards of trial methodology andconsider combined use of Guasha and other therapies.Sufficient sample sizes, validated outcome measures...

... the lactate/ pyruvate ratio [8].All in all, anaerobic energy metabolism is characterized by hyperlactatemia associated with an elevated lactate/ pyruvate ratio, greater glucose utilization and ... phosphorylation [7], thereby inhibiting ATP synthesis and reoxidation of NADH.  is leads to a decrease in the ATP/ADP ratio and an increase in the NADH/NAD ratio. A decrease in the ATP/ADP ratio ... should theoretically be accompanied by hypoxic hyperlac-tatemia. Cardiogenic shock, as demonstrated previously [5], is associated with hyperlactatemia with a very high lactate/ pyruvate ratio....

... gastro-intestinalpropulsion after propofol- or propofol/ketamine-N2O/O2 anaesthesia. A comparison of gastro-caecal transit after isoflurane anaesthesia. ActaAnaesthesiol Scand 1998, 42:664-669.49. Asakura ... respectively; P < 0.001). I nter-estingly, a Glasgow Coma Scale score of less than nine(P = 0.021) was significantly associated with aspirationby univariate analysis. Other risk factors for aspirationincluded ... Toxoplasma gondii. J Pharmacol Exp Ther1990, 252:605-609.54. Di Francesco P, Gaziano R, Casalinuovo IA, Palamara AT, Favalli C, Garaci E:Antifungal and immunoadjuvant properties of fluconazole...

... enrichedgenes from the larval pan-neural (LP), embryonic pan-neural(EP), larval A- class (LA), and embryonic A- class (EA) micro-array datasets. Additional data file 2 is a master annotationfile of ... dataset)(RMF, DMM, unpublished data). The top 50 enriched genes in this dataset were selected on the basis of statistical rank.RNA amplification and microarray data analysis A C. elegans Affymetrix ... was 1500041B16Rik,which did not have a summary graph; expression in the brain in this case was confirmed by direct visualization of the in situphotographs available in the Brain Atlas. C. elegans...

... Collectively, these analyses leave no doubtthat the phagosome, even when it contains only an inertbead, is a complex signaling machine. A systems approach to understanding phagosome function and phagocytosisIn ... phagocytosisIn Dictyostelium, phagocytic uptake of latex beads can behighly synchronized, enabling a detailed kinetic analysis. Incontrast to phagocytosis in mammalian cells, in which the particles, ... phagocytosis as a source of food.Since then, phagocytosis has evolved into a highly complexand regulated process, and is one of the main ways in whichmulticellular animals clear the body of pathogenic...

... polycistron as a potential human oncogene.Nature 2005, 435:828-833.3. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tom-ida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T: A polycistronic microRNA ... constructs (a) (b)00.511.522.53APBB2 -A APBB2-BAPBB2-CAPP -A APP-BAPP-CAPP-DBCL2L11 -A BCL2L11-BBCL2L11-CBCL2L11-DBCL2L11-ECCND1 -A CCND1-BCCND1-CCCND1-DCCND2 -A CCND2-BCCNG 2A CCNG2-BCDKN 1A CDKN 1A- BCDKN 1A- CCRK -A CRK-BCUL3 -A CUL3-BCUL3-CCUL3-DDMTF1 -A DMTF1-BE2F1 -A E2F1-BE2F1-CE2F3 -A E2F3-BE2F5 -A EREG -A EREG-BEREG-CEREG-DFOXO 1A- AFOXO 1A- BFOXO 1A- CFOXO 1A- DFOXO 1A- EFOXO 1A- FGAB1 -A HAS2 -A HDAC4 -A HDAC4-BHDAC4-CHDAC4-DHIF1 -A HIF 1A- BIRF1 -A KHDRBS1 -A KHDRBS1-BKPNA2 -A MAP3K8 -A MAP3K8-BMAPK9 -A MYCN -A MYCN-BNCOA3 -A NCOA3-BNCOA3-CNCOA3-DNR 4A3 -A NR 4A3 -BNR 4A3 -CPCAF -A PCAF-CPDGFRA -A PDGFRA-BPDGFRA-CPKD1 -A PKD2 -A PKD2-BPKD2-CPKD2-DPPARA -A PPARA-BPPARA-CPPARA-DPPARA-EPPARA-FPPARA-HPTEN -A RB1 -A RB1-BRB1CC1 -A RB1CC1-BRBBP7 -A RBL1 -A RBL1-BRBL2 -A RBL2-BRBL2-CRNF111SMAD7 -A STAT3 -A STAT3-BSTAT3-CSTAT3-DTIMP2 -A TIMP2-BTIMP2-BTIMP2-CTNXIP -A TNXIP-BTNXIP-CTP53INP1 -A TP53INP1-BTP53INP1-CTP53INP1-DTP53INP1-ETP53INP1-FTP53INP1-GTSG101 -A WEE1 -A Relative ... constructs (a) (b)00.511.522.53APBB2 -A APBB2-BAPBB2-CAPP -A APP-BAPP-CAPP-DBCL2L11 -A BCL2L11-BBCL2L11-CBCL2L11-DBCL2L11-ECCND1 -A CCND1-BCCND1-CCCND1-DCCND2 -A CCND2-BCCNG 2A CCNG2-BCDKN 1A CDKN 1A- BCDKN 1A- CCRK -A CRK-BCUL3 -A CUL3-BCUL3-CCUL3-DDMTF1 -A DMTF1-BE2F1 -A E2F1-BE2F1-CE2F3 -A E2F3-BE2F5 -A EREG -A EREG-BEREG-CEREG-DFOXO 1A- AFOXO 1A- BFOXO 1A- CFOXO 1A- DFOXO 1A- EFOXO 1A- FGAB1 -A HAS2 -A HDAC4 -A HDAC4-BHDAC4-CHDAC4-DHIF1 -A HIF 1A- BIRF1 -A KHDRBS1 -A KHDRBS1-BKPNA2 -A MAP3K8 -A MAP3K8-BMAPK9 -A MYCN -A MYCN-BNCOA3 -A NCOA3-BNCOA3-CNCOA3-DNR 4A3 -A NR 4A3 -BNR 4A3 -CPCAF -A PCAF-CPDGFRA -A PDGFRA-BPDGFRA-CPKD1 -A PKD2 -A PKD2-BPKD2-CPKD2-DPPARA -A PPARA-BPPARA-CPPARA-DPPARA-EPPARA-FPPARA-HPTEN -A RB1 -A RB1-BRB1CC1 -A RB1CC1-BRBBP7 -A RBL1 -A RBL1-BRBL2 -A RBL2-BRBL2-CRNF111SMAD7 -A STAT3 -A STAT3-BSTAT3-CSTAT3-DTIMP2 -A TIMP2-BTIMP2-BTIMP2-CTNXIP -A TNXIP-BTNXIP-CTP53INP1 -A TP53INP1-BTP53INP1-CTP53INP1-DTP53INP1-ETP53INP1-FTP53INP1-GTSG101 -A WEE1 -A Relative...

... (5'-GGGggtaccGTGAACAAAAGAGATATACAACTAC-3') andStoMcrBC-rev (5'-GGGgtcgacTTAGATTTTACGATTTTCGCCTTTT-3'), or StoMcrBC2-for (5'-GGGggtaccGTGAGGTTAA-GAAAAAGAGATCTAG-3') and StoMcrBC2-rev ... (5'-GGGgtcgacTTAAACCTCTCCCGAAGAGCAGAGG-3'), TkoMcrBC2-for (5'-GGGggtaccATGAATCAATCAGT-TATAATAGATG-3') and TkoMcrBC2-rev (5'-GGGgtcgac-CTAGTTTATTAGCGAATTTAGATAA-3'), StoMcrBC-for (5'-GGGggtaccGTGAACAAAAGAGATATACAACTAC-3') ... H1-ara(GGTTTCGTTTGATTGGCTGTGGTTTTATACAGTCATTACTGCCCGTAATAGTGTAGGCTGGAGCTGCTTC) and H2-ara-BAD (GGCGTCACACTTTGCTATGCCATAGCATTTTTATCCATAAGATTAGCGGAATTCCGGGGATCCGTCGACC) prim-ers. The ΔrecA...