Bóa cáo y học: "Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis" ppt
Bóa cáo y học: "Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis" ppt
... purposes) the leading cause of death in the intensive care unit, and itsincidence is increasing [1,2].Among the many compounds evaluated for the treatment of severe sepsis [3], only drotrecogin alfa ... logistic and Cox regression analysis of DrotAA treatment effect by time to treatmentLandmark logistic and Cox regression analysis of DrotAA treatment effect by time to treatment. With the use of logistic ... finalmanuscript.AcknowledgementsWe thank all the investigators, fellows, study coordinators, nurses, and pharmacists who were involved in and contributed to the trials incorpo-rated into the INDEPTH database. Without their...
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Báo cáo khoa học: "Timing of drotrecogin alfa (activated) treatment in severe sepsis" pps
... frequently involvedpathogen in these pneumonia patients (seven of 12 cases,58%). Notably, and in contrast to the analysis of the INDEPTH data, hospital mortality rates were comparableLetter Timing ... outcome of severe sepsis wasrecently evaluated, using the integrated clinical trial database INDEPTH. The evaluation demonstrated an associationbetween earlier treatment (i.e. treatment within 24 ... within 24 hours of the appearance of first organ dysfunction) and lower patientmortality [1].We assessed the timing of DrotAA treatment in our own(mixed) intensive care unit over a 3-year period....
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Báo cáo y học: "FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions" pot
... to other resources, we first compare the FANTOM4 instance of EEDB and the data contained within to similar genomic resources, and then compare the EEDBsystem to other pre-existing systems. The ... descriptions of the data collected andanalyses used for each of the edge types contained withinEdgeExpressDB, we refer the reader to the FANTOM4 mainpaper [1]; however, here we introduce the data in ... designed to be fully federated. Although this is currently not needed for the FANTOM4 instance, the federation will allow us to easilyexpand the data integration and compare FANTOM4 data to other...
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Bóa cáo y học: "Does productivity influence priority setting? A case study from the field of CVD prevention" ppsx
... thatare financed today.We use a deterministic model to compute the effect of an intervention. The starting point is a cohort of CVD-freeindividuals. Every year the cohort is exposed to the risk of suffering ... neces-sary to analyse the incremental effects and costs of each. The health gains of any particular intervention depend,among other things, on the risk of the target group. There-fore, the population ... 49%reduction in the yearly risk of stroke [14].We calculated the cost per QALY in two ways, according to two sets of cost components in table 1 and 2, and produc-tivity gains were only included in calculations...
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Báo cáo khoa học: Investigations into the ability of an oblique a-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide pot
... instability may contribute to the susceptibility of E. coli model membranes to the action of AP1. An important determinant of the susceptibility of membranes to a-AMPs is the packing characteristics of ... consistent with the peptide penetrat-ing deeply into the membranes hydrophobic core. To investigate further the mechanism of bacterialmembrane interaction used by AP1, thermodynamicanalysis of compression ... elasticity of a monolayer and can be used to characterize the phase state of the isotherm, thereby providing information about the compactness and packing of the model membrane [35]. Val-ues of CÀ1s(Table...
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Báo cáo y học: "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma" pps
... [145]. Confirmation of these findings could mark the beginning of the clinical use of genotyping at an individual level as an adjunct to phar-macotherapy for asthma and many other disorders.Statistical ... understanding of the pathophysiology of thisdisorder, but they also offer significant challenges. Despitemuch progress in defining the genetic basis of asthma andatopy in the last decade, accompanied ... susceptibility loci, and they are intrinsically more pow-erful than linkage analyses in detecting weak geneticeffects [35].Discovery and genotyping of SNPs The past decade has seen an increase in moleculargenetic...
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Báo cáo y học: "Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort" ppsx
... TrzaskomaB, Sundin D: Use of an integrated clinical trial database to eval-uate the effect of timing of drotrecogin alfa (activated) treat-ment in severe sepsis. Crit Care 2006, 10:R74.28. Kanji S, ... 'stable', and may wait a significant amount of time in order to determine a 'clear' increased or increasing risk of death.On the other hand, because many clinicians increasingly view clinical ... the incidence of severe sepsis is steadily increasing, the total number of deathscontinues to increase [1-3]. In the setting of severe sepsis, early multi-modal, goal-directedtherapy including...
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Báo cáo y học: "yrGATE: a web-based gene-structure annotation tool for the identification and dissemination of eukaryotic genes" pdf
... by the annotator. Then, the annotatorcreates a new annotation using the Annotation Tool anddecides to submit the annotation to the community.This newly submitted annotation is listed in the ... forspecifying custom exons, allowing thorough analysis andquick annotation of loci. Annotators access the tool over the web, where they create an annotation, decide to save the annotation in their ... pictorially (10 in panel a) for comparison with the Evidence Plot. A protein-coding region was evaluated using the portal to the (c) ORF Finder and imported into the Annotation Tool (4 in panel...
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Báo cáo y học: "Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury" pps
... CTmorphological analysis to separate the effects of reduction in the amount of aeration from the concomitant increase in the amount of tissue and liquid observed with PEEP reduction. The increase in the ... At the end of the protocol, the ani-mals were killed using an intravenous injection of potassiumchloride while they were deeply sedated.Computed tomography scan procedure and image analysisHelical ... Rrs and morphological analysis of the CT scans during PEEP titration for animal VErs, Rrs and morphological analysis of the CT scans during PEEP titration for animal V. The regions of interest of...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ