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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps

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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx

... throughphagocyte production of transforming growth factor-β and IL-10. In addition, Gas-6 on apoptotic cells binding toreceptor kinases of Tyro 3 family (mer, tyro and axl) down-regulate inflammatory cytokines, ... play pivotal roles in SLE. TLR7 and TLR8 bind to single-stranded RNA, TLR3 todouble-stranded RNA, and TLR 9 to DNA. These receptors are intracellular and are engaged by their ligands in a cyto-plasmic ... suggesting the importance ofDNA methylation and TLR9 in autoimmunity, two commonmedications frequently associated with drug-induced SLE,namely hydralazine and procainamide, inhibit DNAmethylation...
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Báo cáo y học: "NOD-like receptors and inflammation" pot

... ofH. pylori infection are determined by the cag pathogenicityisland, and only strains containing cag pathogenicity islandactivate NF-κB proinflammatory cytokines [105]. Thedelivery of muropeptide ... leucine rich repeat and PYD [pyrin domain]containing 1) termed NLRP1 (NLR family, pyrin domaincontaining 1), and so on.We again refer to the historicterminology of NOD and NALP throughout, ... leucine rich repeat and pyrin domain containing 1; NF-κB = nuclear factor-κB;NLR = NOD-like receptor; NLRC1 = NLR family, CARD domain containing 1; NLRP1 = NLR family, pyrin domain containing...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf

... TLR signaling certainly appears to beinvolved in SLE pathology. Interestingly a polymorphism in Mal, the signaling adaptor used by TLR2 and TLR4, has beenshown to be protective against SLE [47]. ... efficiently degrade cytosolic DNA [54].Ankylosing spondylitis, TLR2 and TLR4Ankylosing spondylitis is a multifactorial and polygenicinflammatory rheumatic disease with a poorly understoodpathophysiology. ... and Nalp3 in arthropathies are becomingclearer and they remain exciting therapeutic options. Oneinteresting example is in aseptic loosening that occurs in 10% of joint replacements, resulting...
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Báo cáo y học: "Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia"

... endoscopy in outpatients with iron defi-ciency anemia. The aim of our study was to investi-gate the incidence of GI pathological findings in symptomatic and asymptomatic patients with IDA and ... these symptoms. Dyspepsia score of patients were minimally 12 and maximally 60. The patients investigated previous smoking history, coronary artery disease, diabetes mellitus and malignancy history ... deficiency in, whom gastrointestinal or systemic signs or symptoms are absent have an underlying ga-strointestinal lesion [24]. Idiopathic iron-deficiency anemia in adults is widely believed...
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Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects" docx

... enzyme function althoughthey induce less hepatotoxicity [7-9]. The atypical AP drugclozapine induces a metabolic syndrome by down-regu-lating cytochrome P450 (CYP450) isozymes and by caus-ing ... and converting them to hydrogen perox-ide and diatomic oxygen. While chronic administration ofthe typical AP chlorpromazine decreases SOD enzymeactivity in the brain and in erythrocytes [61], ... sensitivity in the liverby attenuating insulin and leptin signaling pathways [55].It is interesting that one of the main side effects of atypicalThe qPCR validation of genes differentially expressed...
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Báo cáo y học: " Mucocele-like tumor and columnar cell hyperplasia of the breast occurring in a morphologic continuum" pptx

... of, including themorphologic inter-transitions between, MLT and a varietyof breast proliferations, including intraductal carcinoma,invasive carcinoma, atypical ductal hyperplasia and hyperplasia ... usual type [2-4]. Most invasive carcino-mas that arise in this setting are of the mucinous type [4], and some authors have postulated a morphologic and biologic continuum between MLT and mucinous ... development of invasive carcinoma when theyare identified in a biopsy [7].One analysis of columnar cell lesions by comparativegenomic hybridization found loss of heterozygosity(LOH) involving 16q,...
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Báo cáo y học: "Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema" pptx

... smoking history by measuring seruminterleukine-6, C-reactive protein, and tumor necrosis factor. Expression of perforin, granzyme B, and FasL protein by CD8+ T lymphocytes, CD4+ T lymphocytes, ... (black), and emphysematous smokers (grey).Perforin and granzyme B protein expression by peripheral CD56+, CD3+, CD4+, and CD8+ cellsFigure 4Perforin and granzyme B protein expression by peripheral ... (TNF), and C-reactive protein (CRP) in smokers with emphysema, smokers without emphysema, and in non smokers with normal lung function. Expres-sion of perforin, granzyme B, and FasL protein by systemicT...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx

... stages in the proposed pathway are indi-cated. Genistein is an inhibitor of tyrosine protein kinase and competi-tive inhibitor of ATP in other protein kinase reactions; NaF is a non-specific kinase ... array of proteins encoded by genes directly controlled by NF-κB Protein type Protein Cytokines/growth factors IL-1αIL-1βIL-2IL-3IL-6IL-8IL-12TNF-αLymphotoxin-αInterferon-βGranulocyte ... crucial in determining cellular fate and the inflammatory process regulated by cytokines [36–46,166,164].Regulation of cytokines by ROSROS play a crucial role in the initiation and progression...
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Báo cáo y học: "Bench-to-bedside review: Ventilator strategies to reduce lung injury – lessons from pediatric and neonatal intensive care" ppsx

... prominenthyaline membranes were postulated to be a result of lung immaturity and VILI [47,49].Interestingly, lung disease in those survivors of CDH withpulmonary morbidity closely resembles BPD. In ... transpulmonary pressures. In patients younger than 5 years, the closing capacity of the lung is very close to the functional residual capacity. In thesetting of lung disease and mechanical ventilatory ... HFOV using high and low meanairway pressures in rabbits after saline lavage-inducedsurfactant deficiency, and found that maintainence of lung volumes significantly improved lung compliance and...
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Báo cáo y học: "Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice" pptx

... seemed to be pro-inflammatory in ALI. In the present study, interestingly, our results indi-cated that administration of butyrate in vivo attenuatedpulmonary inflammation in LPS-induced ALI. The ... onsuppression of inflammatory cytokines production and NF-B activation.BackgroundAcute lung injury (ALI) and acute respiratory distresssyndrome (ARDS) are well defined and readily recog-nised clinical ... IL-1b,playakey role in neutrophil recruitment to the lung. There-fore, the reduced neutrophils infiltration in lung bybutyrate administration was partially due to its inhibi-tory effect on cytokines...
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