Báo cáo y học: "Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal" pot
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... phosphorylation of Ó FEBS 2002 NAMI-A affects c-myc gene expression and MEK/ERK phosphorylation (Eur. J. Biochem. 269) 5869 Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A ... counteracted, and ultimately abolished, the increase in c-myc gene expression elicited by PMA in serum-free cells. These results suggestthat inhibition of MEK/ERK signaling by NAMI-A mayhave an ... heavily suggests that the inhibitory effect of NAMI-A on c-myc gene expression mayhave occurred by suppressing ERK1/2 activation and activity elicited by PMA-generated signals.Unlike the ras gene...
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Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by thesubstitution, ... [31].RESULTSErythromycin, Cl-tetracycline and streptomycin inhibit nuclear splicing in vitro The effects of eight different antibiotics (the aminoglycoside,kanamycin, the a minocyclitol glycoside, streptomycin, ... RNA by 9%only (lane 3). T he other three antibiotics, Cl -tetracycline,streptomycin and erythromycin, are clearly inhibitors of nuclear pre-mRNA splicing, as indicated by a largereduction in...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... suggest that the inhibition of HA production was not caused by direct inhibition of HAS activity.Effect of MU on HAS activity in FM100 cells treatedwith MUThe activity of the HAS in FM100 cells ... n-dodecyl-b-D-maltoside;GlcNAc, N-acetylglucosamine; GlcUA, glucuronic acid; HA, hyaluronan (hyaluronic acid); HABP, hyaluronan binding protein;HAS (Has), hyaluronan synthase; MU, 4-methylumbelliferone; spHAS, S. pyogenes ... thelipid environment of membranes, especially the distribution of different cardiolipin species, surrounding hyaluronan synthase.Keywords: hyaluronan; synthesis; Streptococcus; 4-methyl-umbelliferone;...
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Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... into contact in the absence of ATP, curcumin is then able tobind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding(i.e. inhibiting ... point is the mean ^ SD of three determinations.q FEBS 2001 Inhibition of the Ca2ỵ-ATPase by curcumin (Eur. J. Biochem. 268) 6323 Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively ... possiblyincreased. In order to further assess the possibility of curcumin affecting the interaction of ATP binding to the ATPase, thiswas directly measured using [32P ]ATP in the absence of Ca2ỵ(Fig....
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Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt
... Kerenyi, T.D. (1971) Leucylglycinamide released from oxytocin by humanuterine enzyme. Science 173, 827–829.35. Shinoda, M., Miyazaki, A. & Toide, K. (1999) Effect of a novel prolyl endopeptidase ... 0.0005).5816 I. Schulz et al.(Eur. J. Biochem. 269) Ó FEBS 2002 Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition Ingo Schulz1, Bernd Gerhartz1, Antje Neubauer1, ... 9H-fluorenyl-9-ylmethylN-[2-(2-cyano-1-pyrrolidinyl)-1-methyl-2-oxoethyl]carbamate;NHMec, 7-(4-methyl)coumarylamide; PEP, prolyl endopeptidase. Enzyme: prolyl endopeptidase (EC 3.4.21.26).(Received 16 July 2002, revised 20 September...
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Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot
... transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosinekinases and protein kinase C by inositolglycan and diacylglycerolmoieties. ... to study GPtdIns biosynthesis in a variety of cell-types and organisms. In all systems investigated so far,mannosamine was able to inhibit GPtdIns biosynthesis. In T. brucei, mannosamine inhibits ... study glycosylphosphatidylinositol (GPtdIns) biosynthesis and GPtdIns protein anchoring in protozoaland mammalian systems. The effects of these analogues onGPtdIns biosynthesis and GPtdIns-protein...
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Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... 2002 Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+ -binding ... Ca2+ binding and phosphoryl transfer and postulate that the drugbinds to and interferes with the Ca2+entry pathway of the Ca2+-ATPase.MATERIALS AND METHODS2-Aminoethoxydiphenylborate ... M3, M4, M5 and M7. The binding of 2-APB to these sites could influence the movement of the loop between M6 and M7 (L6-7), and reduce access of Ca2+ to their binding sites. Keywords :2-APB; Ca2+-ATPase;...
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Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
... pathogenesis of RA. The principal plasma inhibitor of thrombin is antithrombin, asingle-chain 51 kDa glycoprotein that is synthesized in liver. The inhibitory activity of antithrombin on thrombin is ... presence of HA, supporting the notion that HA could compete withheparin for the heparin-binding region of antithrombin. Remarkably, HA affected the inhibition by antithrombin onlywithin the range ... molecularstructure of HA is analogous to that of heparin, HA mightexert its effect by binding to the heparin-binding region of antithrombin. However, such binding did not stimulate the activity of antithrombin...
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Báo cáo y học: "Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice" docx
... of inhibitors of uptake on the intracellular processing of type II collagen (CII) by dendritic cellsThe effect of inhibitors of uptake on the intracellular processing of type II collagen (CII) ... cells by inhibition of antigen uptake in HLA-DR1- transgenic mice in vitro and in vivo. Electronmicroscopy, confocal microscopy, subcellular fractionation and antigen presentation assays were ... prevents macropinocytosis, inhibitedintracellular accumulation of CII and antigen presentation of the major arthritogenic T cell epitope in both glycosylated and non-glycosylated forms. In addition,...
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Báo cáo y học: " Compression of the radial nerve at the elbow by a ganglion: two case reports" pot
... the metacarpophalangeal joints at the fingers and the interphalangeal joint at the thumb had decreased.Sonography and magnetic resonance imaging of the elbow revealed a cystic lesion located at the ... joint past the proximaledge of the supinator muscle [1,2]. Compressive neuro-pathies of the radial nerve in the radial tunnel can occuranywhere along the course of the nerve and may lead tovarious ... reveals the extent and lobulatedmorphology of the cystic lesion (arrows), which is locateddirectly anterior to the anterior aspect of the radial head.(B) Axial, T2W image at the level of the radial...
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Báo cáo y học: "Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke" pptx
... toinhibit effects of cigarette smoke on airway defense by restoring IFN-γ-dependent antiviral effects.Discussion Epithelial cells in the airway are often targeted by respira-tory viruses, and ... for each sample. Epithelial Cytotoxicity AssaysMitochondrial activity was assessed by quantification of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphe-nyl)-2-(4-sulfophenyl)-2H-tetrazolium ... original work is properly cited.ResearchInhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smokeModestos A Modestou, Lori J Manzel, Sherif El-Mahdy and Dwight C Look*AbstractBackground:...
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Báo cáo y học: "Inhibition of breathing after surfactant depletion is achieved at a higher arterial PCO2 during ventilation with liquid than with gas" ppsx
... study a ventilatory strategy of a moderatePEEP (0.5 kPa) and positive pressure ventilation at 60/min was chosen in a model of surfactant depletion to sim-ulate a relevant clinical situation ... inspira-tory activity is inhibited at higher peak airway pressuresand tidal volumes after lung lavage than before. In cats with surfactant- depleted lungs, inhibition of inspiratoryactivity occurs ... in arterial pH at PNAinhibition between GV and PLV. At inhibition of PNA the arterial PCO2 was lower during GV before lavage than after lavage, but was higher during PLV than during GVafter...
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Báo cáo y học: "Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal" pot
... purposes)RetrovirologyOpen AccessResearchInhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signalAviad Levin†1, Ayelet Armon-Omer†1,4, ... PCR amplification from pT7-7-180-IN.The primers used were: 5'BsrGI: 5'-CCGCCATGTACAAA-GAGCTCAAAAAAATCATCGGTCAG-3' 3 BsrGI: 5'-GCG-GTATGTACACCAGCAGAGTAACCACCGATAC-3' ... the nuclear import of IN protein using yeast and mammalianBinding of IN to importin α as estimated by an ELISA-based systemFigure 6Binding of IN to importin α as estimated by an ELISA-based system....
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Báo cáo y học: " Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120" docx
... purposes)RetrovirologyOpen AccessResearch Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120James M Binley1, Stacie Ngo-Abdalla2, Penny Moore3, ... effectively, if imper-fectly, by measuring Fc-gp120-DC-SIGN binding. Binding of Fc-gp120 chimeras to cellular CCR5Figure 3 Binding of Fc-gp120 chimeras to cellular CCR5. A) Inhibition of Fc-gp120-sCD4 ... to cellular CD4Figure 2 Binding of Fc-gp120 chimeras to cellular CD4. Inhibi-tion of binding of Fc-gp120 chimeras to CEM-CD4 cells by (A) sCD4, (B) Fab b12 or (C) Fab 2G12. Inhibition of binding...
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Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx
... of 12(page number not for citation purposes)RetrovirologyOpen AccessResearchInhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptidesLars Steinstraesser*1, ... occurring HDPsrepresenting different classes for inhibition of early, Env-independent steps in the HIV replication cycle. A lentiviral vector-based screening assay was used to determine the inhibitory ... purposes) The inhibitory effect against the lentiviral vector wasdetermined by preincubation of the vector with human cathelicidin LL37, recombinant human β-Defensin-2,porcine PG-1, fungal Plectasin...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM