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Báo cáo khoa học: "The choice of catecholamines in septic shock: more and more good arguments to strengthen the known position, but don’t lose the faith" pptx

Báo cáo khoa học:

Báo cáo khoa học: "The choice of catecholamines in septic shock: more and more good arguments to strengthen the known position, but don’t lose the faith" pptx

... effects of catecholamines. Nevertheless, for the safe and beneficial use of catecholamines in the stabilisation of septic patients we need hard data concerning the effects of patient outcome. In the ... Comparison of norepinephrine and dobuta-mine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospec-tive, randomized study. Intensive ... to assess the regional effects of catecholamines in patients have several pitfalls [13]. What is the clinical relevance of an increase in blood flow in a hepaticvein? What is the relevance of...
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Báo cáo khoa học:

Báo cáo khoa học: "Some aspects of bud in young oak activity and branch formation" ppt

... of leaves and buds of each flush is termed the ’whorl’ and the remaining longer section of shoot, the ’interwhorl’ stem (Fig. 1 ).Mineral Nutrition In spring 1986 dormant ... for the development of procedures for earlytesting. The following experiments investi-gated the effect of nitrogen nutrition and bud position on the formation of branches in ... times more than lowN plants (Table I). The number of buds forming branchesas a percentage of the total number in whorls and on interwhorl stems for the 1 st and 2nd...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc

Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc

... are indicated relative to the level of wild-type tobacco, taken as 1,referring to the transcripts of CAT1 in the same samples. (C) The total activities of the antioxidant enzymes SOD, CAT and ... stress tolerance. These results increased our understanding of the role of the group C GhMPK2 gene in multiple defense-signaling pathways,including those that are involved in responses to pathogen ... [9]. In tobacco,salicylic acid (SA)-induced protein kinase and wound-induced protein kinase, two MAPKs in group A, wereactivated by inoculation with the tobacco mosaic virus(TMV) [10]. Their...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

... phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 proteinZhengding Su, Ping Xu and ... forsignaling remained obscure and it is also unknown whether the two classes of effectors can bind to B ephrins simulta-neously or if the binding of one affects the binding of the other. We report ... down-stream of the Eph and ephrin molecules appear to lead to the regulation of the cytoskeleton of the interacting cells [1,2,6].Phosphorylation of the well-conserved cytoplasmicdomains of B ephrins...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf

Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf

... shown in Table 2 and Fig. 5. Arrows indicate the bands that are interacting with theseprobes. All the lanes have labelled probes. The adding of extracts and cold probe are indicated in the top of ... member of the fibrinogen family, which includes tenascin, cyto-toxin, and fibrinogen [16–18]. Fibrinogen-like proteinfamily members all contain fibrinogen-related domains(FRED), known to represent ... areseen in cytotoxic T cells, endothelial, intestinal and tropho-blast cells, while specific factors (such as virus and cytokines)are required to induce high levels of fgl2 expression in othercell...
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx

Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx

... turn with the side chain carbonyl group of aspartatehydrogen-bonded to the main chain NH of the precedingarginine, forming a stable heptamer ring, both in the X-raystructure and the solution ... purifying and handling integralmembrane proteins. The instability of these proteins in environments lacking phospholipids and the tendency forthem to aggregate and precipitate has hindered applicationCorrespondence ... of AII and the bound conformation to the antibody Fab131are:(a) the first turn (Asp1 and Arg2) which induces the orientation of the N-terminal part to the C-terminalpart of the molecule;(b) the...
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Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction docx

Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction docx

... Mutating the LL signal to AA in the TAC chimeric protein totally abolished sort-ing of the chimera to an intracellular location, and led to mis-routing to the plasma membrane and ⁄ or block-ing ... GLUT8NICD to the tailless lumenal domain of the IL-2 receptor alpha chain (TAC)protein (interleukin-2 receptor a chain) targeted the protein to intracellularmembranes, indicating that its N-terminal ... surface,reflecting the contribution of clathrin ⁄ AP2-mediatedendocytosis to the sorting of both proteins. In linewith this interpretation, a similar phenotype wasobserved following knockdown of clathrin...
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Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

... activation of the S-phase checkpoint. The Mre11-bind-ing domain is responsible for binding to Mre11 during formation of the Mre11–Rad50–Nbs1 (MRN) complex. The ATM-binding domainat the COOH-terminus ... forma-tion of MRN foci in cells exposed to IR, led to the hypothesis that the MRN complex functions in the sensing of DNA strand breakage and in the activation of the ATM-dependent DNA damage signaling ... of Nbs1 with ATM and the recruitment of ATM to sites of DNA damage, thereby promotingATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and...
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Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt

Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt

... markswere localized in the less intense DAPI-stained regions in the nucleus (representing less condensed euchroma-tin), leaving gaps in the more intense DAPI-stainedregions (representing more condensed ... etc., using synchronizedHeLa cells. Interestingly, each of these MLL-interact-ing proteins (CGBP, Ash2 and Rbbp5) was dissociatedfrom mitotic chromatin, leaving a distinct gap in the mitotic ... cells in a very similar fashion to the MLL1 dis-tribution (Fig. 3). Notably, in our studies, we alsofound the presence of these distinct gaps for MLL1 and interacting proteins in mitotic cells in...
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Báo cáo khoa học: Heterologous expression of a serine carboxypeptidase-like acyltransferase and characterization of the kinetic mechanism potx

Báo cáo khoa học: Heterologous expression of a serine carboxypeptidase-like acyltransferase and characterization of the kinetic mechanism potx

... lead to another 90-fold increase, result-ing in an overall 3900-fold activity compared to the AtSMT cDNA of plant origin. Detailed kinetic analyses of the recombinant protein indicateda random ... attaching restric-tion sites for HindIII and XbaI to the 5¢- and 3¢-ends of the product. By cloning as HindIII-XbaI fragments into the expression vectors pYES2 (Invitrogen) or pDIONYSOS, the PCR ... yield of 9% of the extracted enzyme activity (Fig. 3). The in vitro kinetics of SMT was examined byassaying the conversion of 1-O-sinapoyl-b-glucose(sinapoylglucose = singlc) to 1-O-sinapoyl-l-malateHeterologous...
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