Báo cáo y học: " The HBZ gene, a key player in HTLV-1 pathogenesis" doc

... Ohara Y: In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory mark-ers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ... anti-apoptoticfunctions in lymphoma cell lines [38]. Interestingly, HTLV-1 Tax is known to activate both the classical and the alternative NF-κB pathways, and it has been reported that the alternative pathway is ... Antigen in anATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981, 78:6476-6480.4. Takeda S, Maeda M, Morikawa S, Taniguchi Y, Yasunaga J, Nosaka K,Tanaka...

Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc

... vitrocross-linking experiments revealed that the G-10L mutantprotein is routed to the SecYEG translocon via the SRPpathway, the targeting pathway that is exploited by integralinner-membrane proteins. ... using strain CE1224 as the recipient andstrains IQ85 and strain MM152, respectively, as donorstrains. To obtain strain CE1513, strain MM88 was used asFig. 1. Physical characteristics of the ... Together, these data indicatethat the helix breaker in cleavable signal sequences preventsrecognition by SRP and is thereby, together with the hydrophobicity of the signal sequence, a determinant...

Báo cáo y học: "The quest for a biomarker of circulating osteoclast precursors" docx

... regarding the central importance of phagocytosisto human physiology, which culminated in a Noble Prize andlaid the groundwork for the field of innate immunity at the opening of the last century ... rheumatoid arthritis patients and these cells displayan inflammatory phenotype characterized by increasedrelease of interleukin-1 and tumor necrosis factor followingexposure to lipopolysaccharide ... proliferating monocyte population in controls.Additional studies are needed in patients with inflammatory arthritis“…Since (these cells) aside from their capacity tostretch out prolongations also...

Báo cáo y học: "The Proteomic Code: a molecular recognition code for proteins" docx

... pairs that are physico-chemically more compatiblethan any other amino acid pairs. These physico-chemi-cally highly compatible amino acid pairs are complemen-tary to each other, by analogy to ... acid); the blue circles indicate amino acids with exceptionally high affinity for the attachment points (e.g., acidic amino acids); these cap-ture the amino acids at the attachment point and dissociate ... inter-action has a fundamental role in the physiology ofhumans and animals. Obviously, peptides that can inter-act specifically with regulatory pathways have significantpotential for manipulating these...

Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc

... grants from the National Institutes of Health (AR42457, AR 41974 and AI 44142) and by the Mayo Foundation. Wethank James W Fulbright for assistance in preparing this manuscriptand Linda H Arneson ... inflammatorydiseases initiated an era of clinical investigation and estab-lished the foundation of modern clinical immunology. The original descriptions of antinuclear antibodies by Holmanand Kunkel ... rheumatoidfactor can crosslink Fcγ (crystallizable fragment gamma)receptors. However, in contrast to the animal model,neither for rheumatoid factor nor for any of the otherautoantibodies in RA...

Báo cáo y học: "The prognostic value of baseline erosions in undifferentiated arthritis" docx

... arthritis. Ann Rheum Dis 2008, 67:48-51.20. Tamai M, Kawakami A, Uetani M, Takao S, Arima K, Iwamoto N,Fujikawa K, Aramaki T, Kawashiri SY, Ichinose K, Kamachi M,Nakamura H, Origuchi T, Ida H, Aoyagi ... physical examination andsymptom duration was less than two years. Written informedconsent was obtained from all participants. The study wasapproved by the local Medical Ethical Committee. At inclusion,patients ... scaphoid, distal ulna and distal radius) and in feet, the inter-phalangeal (IP) joint digit 1 and metatarso-phalangeal (MTP) joint in digits 1 to 5. In addition, the radiographs were scored according...

Báo cáo y học: "The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists" potx

... linear, all-inclusive strategy can greatly simplify the situation, as well as maximally leverage the heterogene-ous annotations in the similarity measurement (see Addi-tional data files 11 and ... expectation of the study. The same data analyzed by the Functional Annotation Clustering ToolDue to the redundancy/hierarchy problems in the resultsobtained from traditional annotation tools (Table ... 12provides a hypothetical example to measure the relationshipsof gene-gene pairs by kappa statistics with annotationsorganized in a 'flat' matrix. Additional data file 13 provides a hypothetical...

Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"

... clinical evaluation within the first twodays after arrival, including clinical examinations as wellas radiological evaluation, and where infection was sus-pected by the clinical doctor or indicated ... firstdraft. MS and AL contributed to the design of the studyand the interpretation of the data and made a critical revi-sion of the manuscript. All authors have read andapproved the final manuscript.References1. ... symptomsincluding fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical emergency wardpatients...

Báo cáo y học: "The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey"

... on the anti-biotic use, financial cost and resistance patterns of leading nosocomial pathogens. Materials and Methods Hospital setting and antibiotic policy: NARP was initiated in Turkey in ... Hospital pharmacy computer data-bases, and 2) International Medication System (IMS). Because Turkey is an inflation country we have esca-lated all antibiotic prices. The cost of antibiotics was ... The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey Adalet Altunsoy1, Cenk Aypak2, Alpay Azap1, Önder...

Báo cáo Y học: The reactivity of a-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite pdf

... can contain a substantial amount of free a- hydroxyhaem and this can lead to an incorrect interpret-ation of the nature of the enzyme-assisted conversionof a- hydroxyhaem to verdohaem. The reaction ... M .A. & Roy, A. K.(2000) Heme oxygenase-1 in tissue pathology. The Yin and Yang.Am. J. Pathol. 156, 1485–1488.6. Cary, S.P.L. & Marletta, M .A. (2001) The case of CO signaling:why the ... reductase system was employed in place of sodium dithionite (data not shown). The ﬁndingthat ferric a- hydroxyhaem is only slowly incorporated into the enzyme at neutral pH would explain the apparentbroadness...

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