Báo cáo khoa học: "Recombinant activated protein C: the key is clinical assessment of risk of death, not subset analysis" potx

... that assessment and it was not part of the data collection. The FDA then recommended the CommentaryRecombinant activated protein C: the key is clinical assessment of risk of death, not subset ... having either high or low clinical assessment of risk of death. Unfortunately we do not know what the assessments of risk of death were because clinicians treating the patientwere not required ... in the PROWESS trial. The results of the ADDRESStrial, designed with the purpose of prospectively studying the effect of rhAPC in patients with severe sepsis at low risk of death, supported the...

Báo cáo khoa học: " Recombinant activated protein C in sepsis: endothelium protection or endothelium therapy" docx

... endothelium injury inthese conditions, we can ultimately postulate that rAPC is alsoa therapeutic drug for the endothelium. The earlier the betterIf rAPC is efficient when infused in the early ... necrosis factor concentrations whereasthey remained unchanged in either human septic shock orendotoxemia. The question arises, therefore, as to whether it is truly possible to reconcile all these ... promising [14]. The beneficialeffects of earlier administration of rAPC to appropriatepatients may fit into this paradigm. The futureExtensive in vivo and in vitro studies have focused on the cytoprotective...

báo cáo khoa học: "Recombinant immunotoxin anti-c-Met/PE38KDEL inhibits proliferation and promotes apoptosis of gastric cancer cells" docx

... nodemetastasis in GC [22]. Therefore, c-Met is considereda promsing therapeutic target for this type of cancer[3]. The aim of t his study w as to evaluate the effects of recombinant immunotoxin ... Anti-c-Met/PE38 KDEL induced inhibition of protein synthesis. The ability of IT to inhibit protein synthesis in GES-1, MKN-45 andSGC7901 cells were evaluated by using the [3H]-leucine incorporation ... mediators of apoptosis [29]. Activation of caspase is responsible for multiple molecular andstructural changes in apoptosis [30]. Caspase-3 is apotent effector of apoptosis in a variety of cells...

Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

... Kit-8 is a colorimetric method in which the intensity of the dye is proportional to the number of the viable cells. Brieﬂy, 200 lL of a suspension of PC-9cells was seeded into each well of a ... This ﬁndingstrengthens the possibility that JNK is a mediator of the apoptotic action of AG1478.JNK activity in cells is tightly controlled by both protein kinases such as MKK4 or MKK7 and protein phosphatases ... apoptosis in PC-9 cells.There is a general agreement on the hypothesis that the inhibition of ERK1 ⁄ 2 MAPK and ⁄ or PtdIns3K ⁄Akt growth ⁄ survival signaling cascades leads to apop-tosis of cancer...

Báo cáo khoa học: "Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials" ppt

... summary of differing definitions found in the trauma literature), the clinical diagnosis of coagulopathy is familiar to most intensivists andsurgeons. This is characterized by the clinical assessment ... designed with the intent of being hypothesis-generating and has limitations that deserve comment. It is apost-hoc analysis of the only RCT on the use of rFVIIa intrauma to date. The original ... Novo Nordisk A/S. SBR is a member of the Scientific International Advisory Board for rFVIIa. Novo Nord-isk A/S is financing the article-processing charge. MT is anemployee of Novo Nordisk A/S....

Báo cáo khoa học: "Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological" doc

... purposes did not show any sig-nificantly increased risk of thromboembolism afteradministration of rFVIIa compared with placebo. The meanestimated risk of thromboembolism of 6.42% in the eight ... to the known increasedthromboembolic risk of surgical procedures, it is not possibleto establish an association with rFVIIa on the basis of the cal-culated mean rate of thromboembolism of ... meta-analysis of eight placebo-controlled studies, no increased risk of thromboembolism was seen after administration of rFVIIa.Conclusion The meta-analysis of case series showed that, in amean of...

Báo cáo y học: "Inhaled activated protein C: a novel therapy for acute lung injury" pot

... effect in othermodels of ALI.In the previous issue of Critical Care, Waerhaug andcolleagues [1] test the hypothesis that inhaled activated protein C (APC), a novel therapy approved for the treatment of ... Research Institute and the Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA 94143-0624, USACorresponding ... However, systemic APC adminis-tration is associated with a modest increase in the risk of bleeding, which can be life-threatening. Thus, Waerhaug andcolleagues [1] hypothesized that inhaled aerosolized...

Báo cáo y học: "Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury" docx

... from diminishing the enhanced apoptosis of epithelial and other cell populations which accompanies acute lung injury.In the present experiments, treatment with APC was started before the initiation ... diminishing mortality, in patients with acute lung injury and also is likely to prevent the development of lung injury when used as the initial mode of ventilation [11-14].  erefore, the clinically ... become whether inhaled APC can diminish the severity of lung injury when used in conjunction with low-tidal-volume ventila-tion in the presence of acute lung injury due to sepsis or other etiologies...

Báo cáo y học: " APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial" ppsx

... no evidence exists to justify the use of APCin the early stag es of SAP with specific concerns of risk of hemorrhage in patients with prolonged pancreatitisand pancreatic necrosis [16].Accordingly, ... treatment. The main purpose of this pilotstudy was to focus on this i ssue, because the increased risk of bleeding with APC has raised concerns [11]. The data from randomized trials in severe sepsis ... 14:R139http://ccforum.com/content/14/4/R139Page 7 of 8 The 30-day mortality (not an endpoint) in the APCgroupwas 3of1 6comparedtononeof16inthepla-cebo group (ARR -19%, 95% CIs -38% to 0). The non-survivors had pre-randomization SOFA scores...

Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for ampliﬁcation of mitochondrial apoptotic cell death in human cervical cancer cells pptx

... of the peak to the right in the resulting histogram. Inaddition, exposure of cells to radiation caused redistri-bution of Bax from the cytosol to the mitochondriawithout altering the protein expression ... ‘BH3only’ protein of the Bcl-2 family, in the presence of apoptotic stimuli. The truncated Bid then triggers acti-vation of Bax and ⁄ or Bak and mitochondrial release of pro-apototic molecules into the ... trans-membrane potential of these cells was determined by assaying the retention of DioC6(3) added during the last 30 min of treatment. Afterremoval of the medium, the amount of retained DioC6(3)...

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