Báo cáo khoa học: " Science review: Carnitine in the treatment of valproic acid-induced toxicity – what is the evidence" pot

... formed; this step is needed because the inner mitochondrial membrane is not permeable toacylcarnitines. Valproylcarnitine is then exchanged for free carnitine by carnitine translocase. In the mitochondrial ... neonates develop carnitine deficiencybecause of impaired proximal renal tubule carnitine reabsorption and immature carnitine biosynthesis. The finalstep in carnitine synthesis that occurs in liver ... transporter, therebydecreasing the transport of extracellular carnitine into the celland the mitochondria. VPA also induces reversible inhibition of plasmalemmal carnitine uptake in vitro in cultured...

Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf

... continuous with the sinuses of the medulla, which drain into the central vein of the medulla. The right adrenal vein drains into the inferior vena cava and the left into the renal vein. Hence, the ... ACTH/cortisolsynthesis. In normal individuals administration of an opiateagonist results in a fall in plasma cortisol levels, although itinduces hypotension. In contrast, administration of naloxone,an ... described the clinical aspects of adrenal dysfunction in sepsis, as wellas the role of cortisol replacement in the management of septic shock. In the present review we detail the mechanisms of glucocorticoid...

Báo cáo khoa học: " Science review: Natriuretic peptides in critical illness" pps

... hormones, numbered by their amino acidsequences beginning at the N-terminal end of the ANPprohormone, consist of the first 30 amino acids of the prohormone (i.e. proANP 1–3 0; long-acting natriureticpeptide), ... results should be interpretedcautiously because of the relatively small number of patientsincluded, the finding of a lack of value for prediction of the severity of disease judged by the APACHE II ... also help guide the treatment of systolic leftventricular impairment in the future [80].NP and pulmonary disease In the urgent care setting it is often difficult to distinguishbetween cardiac...

Báo cáo y học: "Science review: Apoptosis in acute lung injury" potx

... hypothesis’ and the ‘epithelialhypothesis’. The former hypothesis suggests that neutrophilapoptosis plays an important role in the resolution of inflamma-tion, and predicts that inhibition of neutrophil ... apoptosis are susceptible to therapeutic intervention. In the present review we examine two important hypotheses that link apoptosis with the pathogenesis of acute lung injury in humans. The first of ... prolong the survival of neutrophils, and thusenhance neutrophilic inflammation. The second hypothesis, the ‘epithelial hypothesis’, suggests thatepithelial injury in acute lung injury is associated...

Báo cáo khoa học: "Clinical review: Corticotherapy in sepsis" pot

... bound to proteins. The two main binding proteins are the cortisol-binding globulin (CBG) and albumin [1].ReviewClinical review: Corticotherapy in sepsisHelene Prigent1, Virginie Maxime2and ... progress in our understanding of the role played by the hypothalamic–pituitary–adrenal axis in the response to sepsis, and of the mechanisms of action of glucocorticoids led us toreconsider their ... Production of the sympatheticsystem hormones (adrenaline [epinephrine] and noradrena-line [norepinephrine]) is localized in the medulla. The adrenalcortex consists of three zones, each of which synthesizesspecific...

Báo cáo khoa học: "Science review: Mechanisms of beta-receptor stimulationinduced improvement of acute lung injury and pulmonary edema" ppt

... in the lung in ALI decreases the capacity of the epithelium to remove edema fluid from the distal airspaces of the lung. Disruption of the integrity of the alveolar–capillary membrane results in ... clearance, they are anti-inflammatory, and they inducebronchodilation. The preclinical studies of the effects of beta-2adrenergic agonists in models of ALI/ARDS open an excitinghorizon of therapeutic ... dopexamine) attenu-ated the inflammatory response, particularly the pro-inflam-matory cytokine expression, the induction of chemokines, and the infiltration of the lung by neutrophils in a septic...

Báo cáo khoa học: "Veterinary decision making in relation to metritis - a qualitative approach to understand the background for variation and bias in veterinary medical records"

... influ-ential interaction between the interviewer and the inter-viewed during the interviews that could influence the statements of the interviewed e.g., the use of leading ques-tions. In the phase of ... between the recording of metritis scores andveterinarians' decision making connected to metritis treat-ment and potential links to data quality. This understand-ing provides insight into potential ... accuracybetween veterinarians is required. The large variation in the use of the metritis scores and treatment criteriabetween veterinarians revealed in this study indicate thatthere is a huge variation...

Tài liệu Báo cáo khoa học: "MACHINE-READABLE COMPONENTS IN A VARIETY OF INFORMATION-SYSTEM APPLICATIONS" potx

...

Báo cáo khoa học: "Lexicon and grammar in probabilistic tagging of written English" doc

... tagged training corpus and upgrading or downgrading likelihoods according to the probability markets against word tags in the lexicon or suffixlist. In the majority of cases, this first order ... the intermediate tag is misleading. The curreat vemm of the CLAWS system requires no pro- editing and auribums the correct won1 tag to over 96 per cent of the input running words, leaving ... that the productions obufined by the ~ analysis am contained in the existing grammar. One se~ance is p~¢seraed at a time. Any mmrs found by the program a~ reported back to the sc~ean, once the...

Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt

... b-1,3-glucanpolymers. The nature of the aromatic residues in the two triads might then be reﬂecting the different func-tional constraints for the two proteins: Exg requiringprecise positioning of laminarin substrate ... subfamilies [15]. The stacking of aromatic residues against the hydrophobic faces of sugar rings is a recurring feature of protein–carbohy-drate interactions [16] and is a critical element of sub-strate ... remodelling[19]. We solved the crystal structure of this GH5enzyme in the presence of two different mechanism-based inhibitors, thereby revealing the close network of interactions that hold the...

Xem thêm