... Crs,
Ccw, and Cl are the compliances of the respiratory system,
chest wall, and lung, respectively (Fig. 2 and Table 1).
Review
Clinical review: Respiratory mechanics in spontaneous and
assisted ... detrimental in
ARDS. In 2000, findings were reported by the ARDS
Network investigators [21]. In that prospective, randomized,
Critical Care October 2005 Vol 9 No 5 Grin...
... cerebral injury and
respiratory failure, they observed an increase in intracranial
pressure at the end of RMs and a subsequent reduction in
mean arterial pressure resulting in a decrease in cerebral ... PEEP set at 2 cmH
2
O above the lower inflection point
was more effective in maintaining gas exchange and minimiz-
ing inflammation and lung injury than was PEEP set at the...
... with
recruitment in several experimental [121,123] and clinical
studies [2,124]. On the other hand, an increase in PaCO2
and reduction in compliance of the respiratory system likely
indicate overstretching ... difference in ITP.
Relationship between airway pressure,
intrathoracic pressure and lung volume
A lot of confusion exists, both in the literature and at the
bedside,...
... could be divided into two
groups: the first with decreasing LVEDVI and decreasing CI
on serial measurements, and the other group with progres-
sively increasing LVEDVI and maintained CI.
There ... Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA,
Schein RM, Sibbald WJ: Definitions for sepsis and organ
failure and guidelines for the use of innovative therapies in
sepsis. Chest 19...
... to proteins. The two main binding proteins are
the cortisol-binding globulin (CBG) and albumin [1].
Review
Clinical review: Corticotherapy in sepsis
Helene Prigent
1
, Virginie Maxime
2
and Djillali ... metabolism,
activating osteoclasts, inhibiting osteoblasts, decreasing
intestinal calcium uptake and increasing calcium urinary
secretion by decreasing its renal reabsorption [1].
Im...
... proper training in the management of
acutely ill patients and an understanding of the interface
between acute medicine and intensive care.
Medical emergency teams
The concept of a better integrated, ... for their care, and that reduce discontinuities in
clinical care. The key to this is empowerment through ade-
quate resourcing and training, and simple methods of clinical
monito...
... M, Madsen CD, Barton CW, Sounders CE, Pointer J: A
randomized clinical trial of high-dose epinephrine and norepi-
nephrine vs standard-dose epinephrine in prehospital cardiac
arrest. JAMA 1992, ... of
confounding variables such as scenarios involving immediate
and well performed bystander CPR or scenarios of chest pain
or ventricular tachycardia (with spontaneous pulses) deterio-
rati...
... for infection, including
vancomycin–heparin and vancomycin–ciprofloxacin–heparin
solutions [42,44]. Because the use of vancomycin is an inde-
pendent risk factor for the acquisition of vancomycin-resistant
enterococci ... been demonstrated in clinical studies
[15,25], an in vitro study demonstrated a 10- to 16-fold
increase in the minimal inhibitory concentration of the minocy-
cline–...
... taking into account the intrin-
sic PEEP (the expiratory pause preceding the inflation). A
cursor permits one to measure linear compliance and the
lower inflexion point. A maximal pressure and ... lower inflexion point is definitively not a
‘magic’ point reflecting the opening pressure of the lung. More-
over, the clinical relevance of the study is high since the lower
inflexion point of...
... norepinephrine to
versus phenylephrine 3.2 phenylephrine
[11] 12 Epinephrine 0.7 ±0.1 LD ↑ in mucosal blood flow NA Epinephrine, norepinephrine in
versus norepinephrine 1 ±0.6 with epinephrine and ... of dopamine, norepinephrine and epinephrine on
the splanchnic circulation in moderate and in severe septic
shock, and the main results are as follows. In moderate septic
shock...