... AccessResearch Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse modelGuan-Hong Shang*1, Dian-Jie Lin2, Wei Xiao1, Chong-Qi Jia3, Yu Li1, Ai-Hua Wang1 and ... Thus,delayed release of HMGB1 can participate in the down-stream development of lung injury, and HMGB1 may bea distal mediator of acute inflammatory lung injury. Ethyl pyruvate (EP), a very simple ... Intratrachealadministration of HMGB1 produced acute inflammatory lung injury, and anti-HMGB1 Abs decreased the migra-tion of neutrophils to the lungs as well as lung edema in endotoxin-induced acute lung inflammation...