Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications" potx
Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications" potx
... review: Extracellular acidosis and the immune response: clinical and physiologic implicationsJohn A Kellum1, Mingchen Song2 and Jinyou Li31Associate Professor, Critical Care Medicine and ... understanding of the relationship between pHo and the synthesis and release of inflammatory molecules.Investigators continue to seek means to modulate the inflammatory response as primary therapy ... is not yet known, but their magnitudesuggests that they may play an important role in the development or maintenance of immune dysfunction. If this is the case, then they represent attractive...
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Báo cáo y học: "Science review: Genetic variability in the systemic inflammatory response" pdf
... inflammatory response is dictated by avariety of factors, including the pathogenicity and duration of the stimulus, and the balance between the proinflammatory and anti-inflammatory response. ... predominantly vascu-lar diseases, and the study conducted by Marshall and col-leagues [57] suggests that the renin–angiotensin system mayplay a key role in the pathogenesis of ARDS.An entirely different ... promoter genotypes, including asthma severity,inflammatory bowel disease, rheumatoid arthritis, and sys-temic lupus erythematosus. The only published study of IL-10genotype and severe sepsis...
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Báo cáo y học: "Science review: Role of coagulation protease cascades in sepsis" ppt
... (pericytes, cardiomyocytes, smoothmuscle cells, keratinocytes) and by vascular monocytes and endothelial cells upon induction by inflammatory cytokines orendotoxin [3]. TF is the high-affinity cellular ... systems [21].Physiologically relevant primary endothelial cells express bothPAR1 and PAR2 but, unlike the finding in heterologousexpression systems, APC selectively activates PAR1 inendothelial ... TF–VIIa, thenno thrombin is generated in vivo. The ternary TF–VIIa–Xacomplex is the target for physiologic regulation by TFpathway inhibitor (TFPI), which simultaneously interacts withVIIa and...
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Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx
... circulatory system, exitingonly when they are summoned by signals that emanate from the extravascular compartment. Other cells of the innate immune system, including the macrophage and the dendriticcell, ... septic shock. In part, they do so bytriggering the release of many secondary cytokines, includ-ing IL-6, and numerous chemokines, which may further con-tribute to the septic syndrome.It should ... 41 The downstream effects of these cytokines are exceedinglycomplicated. Together, however, they act to alter coagula-tion, induce fever, and cause hypotension and tissue injury,as is widely...
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Báo cáo y học: "Science review: Mechanisms of ventilator-induced injury" pps
... partial pressure for oxygen to the fraction of oxygen in the inspired air.240lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl ... patients for the recent randomized, controlledAcute Respiratory Distress Syndrome Network study. The patients who meet the clinical criteria of the current definitiontherefore benefited from the Acute ... highlights the fact that the primary difference between the groups was in end inspiratory lung volume.Furthermore, the mortality benefit persisted regardless of the initial respiratory system compliance....
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... infiltration into the lungs and toincreased pulmonary proinflammatory cytokine expression [7].However, the initial events induced by hyperoxia, therebyleading to acute inflammatory lung injury, remain ... anti-inflamma-tory therapy for CF lung disease and could possibly promoteclearance of secretions in the CF airway in a NF-κB-dependent manner.Hyperoxia (hyperbaric levels of oxygen) and reactive ... tenacious,protease-rich and oxidant-rich purulent airway secretions thatare difficult to clear, even with physiotherapy. In the search fora potential treatment, Ghio et al. tested tyloxapol, an alkylarylpolyether...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... kidneys [48]. In otherorgans, VEGF gene expression is induced by hypoxia and bycytokines. To identify the cellular mechanisms in control oftubular VEGF production, the effects of hypoxia and ... γγ-glutamylcysteine synthetase, augments LPS-mediated pro-inflammatory cytokine biosynthesis: evidencefor the implication of an IκκB-αα/NF-κκB insensitive pathway. EurCytokine Netw ... TNF-ααbiosynthesis: augmentation by irreversible inhibitionof gamma-glutamylcysteine synthetase and the involvementof an IκκB-αα/NF-κκB-independent pathway in alveolar epithelialcells....
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Báo cáo y học: "Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance" docx
... that exhibit specificity for both the type of leukocyteon which they are expressed and the ligand to which theybind. The specificity of chemoattractant-induced leukocytechemotaxis is related ... myeloid stem cells; the myeloblast differentiates into the promyloblast, and then into the myelocyte. These cells differ-entiate into metamyelocytes as well as segmented band neu-trophils, which ... erythrocytesmove faster than the larger leukocytes, especially in the centerof the vessel, pushing leukocytes to the vessel periphery [12].Physical forces involved in the erythrocyte–leukocyte interac-tions...
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Báo cáo y học: "Science review: Apoptosis in acute lung injury" potx
... neutrophils and release ofcytokines by macrophages The third mechanism whereby apoptosis of neutrophils canmodify the inflammatory response is by modulating the pro-duction of proinflammatory cytokines ... apoptosis in the lungs of mice. They then showedthat the mortality and the lung injury that followsischemia/reperfusion decreased significantly when neutrophilapoptosis was enhanced by aerosolization ... primarily the proinflammatory cytokines granulocyte colony-stimulatingfactor and granulocyte/macrophage colony-stimulating factor(GM-CSF), and possibly IL-8 and IL-2 [7–10]. However, the importance of...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc
... probably related to a polymorphism of the plateletV1R [49].V1Rs are found in the kidney, where they occur in high densityon medullary interstitial cells, vasa recta, and epithelial cells of the ... neutral oxytocin evolution. Adv Exp Med Biol 1995,395:615-627.3. Oliver H, Schaefer EA: On the physiological action of extractsof the pituitary body and certain other glandular organs. JPhysiol ... homologyexists between the V3R and the V1R [59]. The oxytocin receptor The OTR can be considered a ‘nonselective’ vasopressinreceptor. The OTR has equal affinity for vasopressin and oxy-tocin,...
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