Báo cáo khoa học: " How to compare adequacy of algorithms to control blood glucose in the intensive care unit" pptx

... serum insulin-like growth factorbinding protein 1 concentration both have AUCs of the ROC of about 0.8 (the latter being an indicator of hepatic insulinresistance or lack of insulin effect on the ... titrated intensive insulin therapy to maintain a blood glucose below 6.1 mmol/l throughout intensive care. The observation by Vogelzang and coworkers[1] of a slightly better AUC of the ROC when the ... number of blood glucose measurements, ideally a continuous or close to continuous blood glucose reading over time. Secondly, in order to compare blood glucose control in two patient groups usingthe...

Báo cáo y học: "Pro/con debate: Should antimicrobial stewardship programs be adopted universally in the intensive care unit" potx

... men-tation of guidelines and clinical pathways improving antimicrobial prescribing behaviour. For example, studies using algorithms to shorten the course of antimicrobial therapy in ventilator-associated ... distribution of educational materials.Another challenge to implementing antimicrobial steward ship in the ICU deals with the conﬁ dence inten-sivists have in the clinical judgement of the stewardship ... feedback avoids delays in initiation of therapy and maintenance of prescribers’ autonomy, and can be imple-mented in health care facilities of varying sizes [23,24]. A large teaching hospital reported...

Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx

... content compared to other proteins.Four of them, M69, M130, M133, M138, deﬁne a clus-ter in the 3D structure, approximately located in the internal side of the peanut. The results of the crystallo-graphic ... coordinated in a small cavity of the surface at the polar opposites of each monomer, close to another dimer present in the crystal packing and partially involving it in the coordination. It is ... ﬁndings may indicate that CagDis released into the supernatant during host cell infec-tion by an unknown independent mechanism and thenbinds to the host cell surface or is incorporated in the pilus...

Báo cáo khoa học: Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family pdf

... Wetherefore characterized the regions in the brain show-ing the expression of lamprey PQRFamide peptidemRNA using in situ hybridization. The expression waslocalized mainly in the NCP in the ... in the regulation of locomotor activity. In mammals, in situ hybridizationreveals that the nucleus of the solitary tract and dorsalhorn of the spinal cord express the highest levels of the mRNA ... demonstration of the presence of RFamide pep-tides in the brain of any species of agnathans. On the basis of the results of phylogenetic analysis andamino acid sequence comparison, the identiﬁed...

Báo cáo khoa học: Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus pptx

... structure, either in SsMTAPII [20] or in Erv2p[42] the CXC motif is part of a ﬂexible C-terminalsegment that can swing into the vicinity of anothercysteine pair. In particular, in Erv2p the CGC ... shown in the absence (d)or in the presence of 100 mM phosphate(j). Apparent Tms are reported in the inset.(B) Kinetics of thermal inactivation of PfPNPas a function of incubation time. The enzyme ... in the absence of phosphate, it appears completelyinactive. It is interesting to note that no protectiveeffect against SDS inactivation has been observed in the presence of inosine indicating...

Báo cáo khoa học: "Survival methods, including those using competing risk analysis, are not appropriate for intensive care unit outcome studie" docx

... authors introduce the use of the Fine and Grey regression model [2], based on the cumulativeincidence function (CIF), to analyze data from outcome studies in the intensive care unit (ICU). They show ... benefit the patient and, therefore, should not be measured in the statisticalanalysis.Introduction In Evaluating Mortality in Intensive Care Units: Contribution of Competing Risks Analysis [1], the ... appropriate when total mortality is the outcomebecause deaths after the patient leaves the hospital are notincluded in the CIF. In an analysis of total mortality, censoringis the last time the patient...

Tài liệu Báo cáo khoa học: Interferon-a induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand ppt

... following the binding of TRAIL to its receptorsand the formation of the death-inducing signallingcomplex [30], is required for the inhibition of transla-tion. The data in Fig. 2A show that in ... observedincreased association of the inhibitory protein eukary-otic initiation factor 4E-binding protein (4E-BP1)with the mRNA cap-binding factor eIF4E in cellsKeywordscaspases; interferon-a; ... cells,although densitometry of the immunoblots showed that in this case there was no measurable increase in the level of the proenzyme in cells treated with IFNa in the absence of TRAIL (Fig. 4B,C). In contrast...

Tài liệu Báo cáo khoa học: Puriﬁcation and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulﬁde reductase from methanogenic archaea pdf

... reoxidizesmenaquinol and transfers the e lectrons either to an electronacceptor on the extracytoplasmic side of the membrane or to an acceptor in the cytoplasm. The latter electronacceptor, which ... an intrin sic property of the enzyme. In this case, the signal could, for example, b e g enerated by the co-ordination of a redox-active cysteine residue of the enzyme to a metalcluster. The ... on the cytoplasmic side.It cannot, however, be excluded that this protein binds to the AF499 protein in the cytoplasm and that this proteincomplex then is translocated across the cytoplasmic...

báo cáo khoa học: "How can continuing professional development better promote shared decision-making? Perspectives from an international collaboration" pptx

... 5 of 5educational features: their conceptual underpinnings; the rationale for developing the program; the sources thatinformed the program; the healthcare professionals tar-geted; the clinical ... for the meeting w as to present the preliminaryresults of the scan and to explore how to improve andcomp lete this part of our protocol [12]. Briefly, we reliedon three m ain sources of data: ... [37]; and informa-tion about how the program was assessed, including the levels of assessment (i.e., participants’ reaction, theirdegree of learning, changes in their behavior, and changes in patient...

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