... hydroxylation of Pro, Val or Lys, c-carboxylation of Glu, glycosylation of Ser or Thr, bromination of Trp, sulfation of Tyr, cyclization of N-terminal Gln, and epimerization of several different residues. ... 4.70 p.p.m. and a spectral window of 6000 Hz, as described previously [22].Spectra were processed with topspin or xwinnmr soft-ware. Phase-shifted sine-squared window functions wereapplied ... both samples of conomarphin and l-Phe13-conomarphin were recorded at 300 K and pH 3.Restraint set generationAn initial survey of distance constraints was performed ona series of NOESY spectra...