Báo cáo khoa học: "Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patient" ppsx

... creatinine at initiation of colistin; Cr2, highest value of creatinine during treatment with colistin; Cr3, serum creatinine 7 days aftercompletion of treatment with colistin; CVVHD, continuous ... for the severity of illness.Because mortality rates in the region of 50–60% have beenreported in critically ill patients receiving inappropriate treat-ment [1–7], the use of colistin may indeed ... hours of the initiation of colistin; these patients were not included in the analysis because theywere not considered true therapeutic failures. Data on the remaining 24 patients are presented in...

Báo cáo y học: "Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosis" ppt

... colistin as monotherapy; she hadreceived intravenous colistin therapy before aerosolized colis-tin for 7 days and continued to receive the intravenous therapyafter the end of aerosolized therapy ... creatinine value (mg/dl) on the first day of aerosolized colistin administration1.1 5.2 1 0.4 2.4 0.6 0.8 0.8Serum creatinine value (mg/dl) at the end of aerosolized colistin administration0.8 ... the other seven patients during colistin treatment. Onepatient had baseline serum creatinine levels of 5.4 mg/dl, andat the end of colistin treatment serum creatinine haddecreased to 4.5 mg/dl....

Báo cáo y học: "Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosi" pdf

... abandonment of colistin in clinical practice. As a consequence there is only a paucity of physicians with clinical experience in the use of this class of antimicrobials. The spectrum of activity of the ... describe the use of inhaled colistin in the treatment of multidrug-resistant Gram-negative nosocomial pneumonia in a small group of patients. Although seven of eight patients who receivednebulized colistin ... Acinetobacter spp., the necessity toexplore other therapeutic avenues has led investigators toconsider older agents, including the tetracyclines andpolymixins. The polymixins are a class of...

báo cáo khoa học: "New targets for the treatment of follicular lymphoma" potx

... MDM2, thus mimicking the binding of the helical portion of p53. However, one of the enanti-omers of this racemic mixture of compounds was foundto possess higher affinity for the binding site as ... summarizes the growing body of knowledge regarding noveltherapeutic targets, enabling the concept of individualized targeted therapy for the treatment of FL.IntroductionNon-Hodgkin's Lymphoma ... eventually culminate in the activation of a pro-teolytic cascade involving members of the caspase family. The process of apoptosis can be divided into initiationand execution phases. Initiation of apoptosis...

Tài liệu Báo cáo khoa học: cN-crystallin and the evolution of the bc-crystallin superfamily in vertebrates pdf

... adaptations in the eye in the human lineage. In addition to the evolution of cN and cS crystal-lins, even more specialization in the c-crystallins hasoccurred with the loss of the N-terminal arm in the ancestor ... lost the intron dividing the exonsencoding the ﬁrst domain. The next step in the evolu-tion of the c-crystallins was cS-crystallin, in which asecond, symmetrical intron loss occurred to give the ‘modern’ ... concentration role of anormal crystallin and may instead have a separatefunction. The expression of cN in the retina is particularlyinteresting. There is evidence for expression of cSin the retina and...

Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating ﬁbrinolysis doc

... activity of the re-grown clones was deter-mined again by incubating the activated CPU at 37 °C andusing the same protocol as used in the primary screeningdescribed above.Determination of the half-life ... mutations in the region following position 314 in CPU.Fifty per cent of the residues mutated in the clonesselected from the ﬁrst round of FINDTMare located in a distinct region encompassing residues ... P329 in porcine CPB (numbering accordingto Fig. 2). Keeping a strict orientation of the sidechains, replacing P300 with a serine would leave the H-bond to the OH group of the side-chain nonsatis-ﬁed,...

Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot

... distribution of BsArb43B in the proximity of the active site. Arabinotriose in the binding cleft is representedusing sticks. (B) Detailed view of the binding cleft with arabinotri-ose. (C) Details of the ... witharabinohexose [15], this loop makes the reducing end of the carbohydrate chain bend towards the solvent,probably optimizing binding of the carbohydrate chain in the cleft, and resulting in trioses ... for the optimal activity of BsArb43B.Furthermore, to determine whether the role of the calcium is structural, thermal shift assays were per-formed to determine the Tm of the protein in the...

Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot

... frame encoded by the PR-1a gene, and differsby only six amino acids from the PR-1a preprotein in the N-terminal moiety of the protein. Most importantly, the W38-1 pseudogene part of the W38-1::PR-1a ... adistinct host response depending on the genetic constitution of the plant and the pathogen. In an incompatible inter-action, the pathogen remains localized at the primaryinfection sites that often ... increased signiﬁcantly in the nahG transgenic plants in parallel with the induction of necrosis by the expanding lesions (Fig. 6B). Our ﬁnding of substantial amounts of PR-1 proteins in nahG plants isconsistent...

Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx

... a certain level of TRa (Fig. 6A). As in the HeLaTR cells, T3 treatment of the FRTL cells signiﬁcantlyincreased the level of the 4-1BB mRNA and decreased the level of the BMP6 mRNA. Furthermore, ... modulated during bothearly and late responses.We also examined the expression of TRAF1 and TRAF2because they interact and regulate the function of the 4-1BBproteins to induce NF-jB [18]. In the absence ... mRNA, the expression of TRAF1 was induced asearly as 1 h after the T3 treatment and the TRAF1 mRNAlevels continued to increase up to 48 h (Fig. 3B). On the other hand, certain amounts of the...

Báo cáo khoa học: "A step towards the detection of semantic variants of terms in technical documents Thierry Hamon and Adeline " potx

... ap- plied to the links extracted from the dictionary. Indeed, while the synonymy is sometimes very contextual in the dictionary, the links appear in the data without context information and ... of wrong links is rather important in the list presented to the expert: between 10 to 20 links out of 396. On the contrary, about ten wrong links are due to the elision of common terms in ... relation. For instance, in graph theory, the link (arbre (tree) / feuille (leaf)) can be inferred from the meronyny in- formation of general dictionary. Those types of wrong links are easily...

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