Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps

... nitric oxide (NO); and potentiation of adrenergicReviewScience Review: Vasopressin and the cardiovascular system part 2 – clinical physiologyCheryl L Holmes1, Donald W Landry 2 and John T Granton31Staff ... of others. Vasopressin and the heart The actions of vasopressin on the heart are complex and the studies are seemingly contradictory. Depending on the species studied, the dose used, and the ... 1997,95:1 122 -1 125 .4. Landry DW, Levin HR, Gallant EM, Seo S, D’Alessandro D, OzMC, Oliver JA: Vasopressin pressor hypersensitivity invasodilatory septic shock. Crit Care Med 1997, 25 : 127 9- 128 2.5....

Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc

... causeReviewScience Review: Vasopressin and the cardiovascular system part 1 – receptor physiologyCheryl L Holmes1, Donald W Landry 2 and John T Granton31Staff intensivist, Department of Medicine, Division ... V3pituitary and oxytocin receptors, and the P 2 class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions ... actions of vasopressin on the vascular system. In part 2 of the review we discuss the effects of vasopressin on vascular smoothmuscle and the heart, and we summarize clinical studies of vasopressin...

Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf

... 29 6:996-1005. 62. Haddad JJ, Land SC: O 2 -evoked regulation of HIF-1αα and NF-κκB in perinatal lung epithelium requires glutathione biosyn-thesis. Am J Physiol Lung Cell Mol Physiol 20 00, 27 8:L4 92- L503.63. ... associated with the development and progressionof many human disease states and inflammatory-relatedinjury, particularly of the lung [3]. Their ultimate regulationtherefore bears potential therapeutic ... infiltration into the lungs and toincreased pulmonary proinflammatory cytokine expression [7].However, the initial events induced by hyperoxia, therebyleading to acute inflammatory lung injury, remain...

Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx

... reactive oxygen species; SAPK, stress-activated protein kinase.COOxyDe-oxyLowO 2 OxyDe-oxyHigh O 2 Co 2+ Ni 2+ OxyDe-oxyNAD(P)H Oxidase?ECFICFO 2 O 2 O 2 . – NADPHNADPH 2 O 2 ?Fenton ... hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 20 02, 22 :22 83 -22 93.55. Shimaoka M, Fujino Y, Taenaka N, Hiroi T, Kiyono H, Yoshiya II.High frequency ... Normoxicinduction of the hypoxia-inducible factor 1ααby insulin and interleukin-1ββinvolves the phosphatidylinositol 3-kinasepathway. FEBS Lett 20 02, 5 12: 157-1 62. 50. Haddad JJ, Land SC: A non-hypoxic,...

Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx

... circulatory system, exitingonly when they are summoned by signals that emanate from the extravascular compartment. Other cells of the innateimmune system, including the macrophage and the dendriticcell, ... septic shock. In part, they do so bytriggering the release of many secondary cytokines, includ-ing IL-6, and numerous chemokines, which may further con-tribute to the septic syndrome.It should ... inflammation and shock [20 ,21 ] and appears to synergize with TNF, diminishing the 50% lethaldose of the latter [22 ]. Although it lacks the toxicity of eitherTNF or IFN-γ when administered by itself,...

Báo cáo y học: "Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance" docx

... erythrocytesmove faster than the larger leukocytes, especially in the centerof the vessel, pushing leukocytes to the vessel periphery [ 12] .Physical forces involved in the erythrocyte–leukocyte interac-tions ... nonlinear systems. CritCare Med 20 00, 28 :21 93 -22 00.Available online http://ccforum.com/content/7/4 /29 1 29 2Critical Care August 20 03 Vol 7 No 4 Seely et al.cussion and interpretation of the importance ... that exhibit specificity for both the type of leukocyteon which they are expressed and the ligand to which theybind. The specificity of chemoattractant-induced leukocytechemotaxis is related...

Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications" potx

... on the immune system [3,4]. Abnormalities insystemic acid–base balance may also induce significantalterations in the immune response. The clinical significanceof these alterations is not yet ... hyperpermeability inCaco-2BBe cultured intestinal epithelial monolayers. Am JPhysiol 1997, 27 2:G1007-G1 021 . 42. Gonzalez PK, Doctrow SR, Malfroy B, Fink MP: Role of oxidantstress and iron delocalization ... and T cell-mediated injury. Am JPhysiol Renal Physiol 20 03, 28 5:F87-F94.3. Joyce DE, Grinnell BW: Recombinant human activated proteinC attenuates the inflammatory response in endothelium and monocytes...

Báo cáo y học: "Science review: Role of coagulation protease cascades in sepsis" ppt

... activates PAR1 and PAR2 [20 ]. Neither Xa generated by the intrinsic activationcomplex VIIIa–IXa nor Xa bound to Va signals efficientlythrough PARs [19 ,20 ]. TF–VIIa can also activate PAR2 [20 ,22 ], but ... systems [21 ].Physiologically relevant primary endothelial cells express bothPAR1 and PAR2 but, unlike the finding in heterologousexpression systems, APC selectively activates PAR1 inendothelial ... protease-activated receptor 2 byfactor VIIa. Proc Natl Acad Sci USA 20 00, 97: 525 5- 526 0. 23 . Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, EsmonNL, Esmon CT: The crystal structure of the endothelial proteinC...

Báo cáo y học: "Science review: Mechanisms of ventilator-induced injury" pps

... of arterial partial pressure for oxygen to the fraction of oxygen in the inspired air. 24 0lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. ... PEEP,14.8 cmH 2 O). In the lower tidal volume group, the PEEP wasset above the lower inflection point of the respiratory system pressure–volume curve (Fig. 2) . Plasma and BAL cytokineswere then measured ... Matthay MA:Low tidal volume reduces epithelial and endothelial injury inacid-injured rat lungs. Am J Respir Crit Care Med 20 02, 165: 24 2 -24 9.41. Imai Y, Nakagawa S, Ito Y, Kawano T, Slutsky AS,...

Báo cáo y học: "Science review: Apoptosis in acute lung injury" potx

... primarily the proinflammatory cytokines granulocyte colony-stimulatingfactor and granulocyte/macrophage colony-stimulating factor(GM-CSF), and possibly IL-8 and IL -2 [ 7–1 0]. However, the importance of ... Allergy Immunol 20 00, 122 :20 9 -21 5.33. Kuwano K, Hagimoto N, Kawasaki M, Yatumi T, Nakamura N,Nagata S, Suda T, Kunitake R, Maeyama T, Miyazoki H, Hara N:Essential roles of the Fas–Fas ligand ... neutrophils and release ofcytokines by macrophages The third mechanism whereby apoptosis of neutrophils canmodify the inflammatory response is by modulating the pro-duction of proinflammatory cytokines...

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