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Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf

Báo cáo y học:

Báo cáo y học: " Liver sinusoidal endothelial cell modulation upon resection and shear stress in vitro" doc

... (0.05)Morphometric analysis evaluating the number of gaps per area along the sinusoidal endothelial lining, studied by SEM. Results are expressed as mean (standard deviation) and significance was determined ... days. Endothelial cells lining liver sinusoids are likely to be thefirst to sense changes in shear stress. Those cells are uniqueas they have no typical basal lamina. Moreover, the cellsare ... par-tial hepatectomy in rats. J Hepatol 1999, 30:911-915.14. Kraizer Y, Mawasi N, Seagal J, Paizi M, Assy N, Spira G: Vascular endothelial growth factor and angiopoietin in liverregeneration....
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Báo cáo y học:

Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf

... synthase. Circulation 2000, 101:931-937.85. Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, IzumidaT, Minamino N, Ju KH, Morita H, Oh-hashi Y, Kumada M, KangawaK, Nagai R, Yazaki Y: ... theprincipal activator of the extrinsic coagulation pathway, and assuch is responsible for an intravascular procoagulant state.Taylor and coworkers concluded that sustained injury to thevascular ... demonstrate that ECsurface modification occurs easily and rapidly [5,6], with ECsbeing detached from the internal elastic lamina with an indica-tion of subendothelial oedema. As early as 15 min after...
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Báo cáo y học:

Báo cáo y học: "Systematic review: Intra-aortic balloon counterpulsation pump therapy: a critical appraisal of the evidence for patients with acute myocardial infarction" doc

... end of initial coronary angiography to 48 hof prophylactic IABP therapy (n = 23) or standard care (n= 22). The primary endpoint was IRA patency (defined asThrombolysis in Myocardial Infarction ... not broadsince data for this economic analysis was only based oninhospital billings. It may be argued that from an economicstandpoint, the advantages or disadvantages of IABP ther-apy may be ... trial, Talley et al[18]should have adjusted their analysis to assume that incom-plete efficacy is actually achieved in clinical practice. Talleyet al's costs were measured accurately by...
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Báo cáo y học:

Báo cáo y học: " Clinical review: Timing and dose of continuous renal replacement therapy in acute kidney injury" ppsx

... After adjustment for age and clinical factors andstratification by site and initial modality of RRT in a multi-variate analysis, the relative risk of death associated withdialysis initiation ... outcomes in patientswith post-traumatic AKI by stratifying 100 consecutivepatients based on the BUN at initiation of treatment. ‘Early’and ‘late’ initiation of therapy were defined by stratifyingpatients ... in the intensive treatment arm and approximately100 mg/dl in the non-intensive arm. The average time toinitiation of dialysis was 5 ± 2 days in the intensive arm and7 ± 3 days in the non-intensive...
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Báo cáo y học:

Báo cáo y học: "Liver sinusoidal endothelial cells represents an important blood clearance system in pigs" doc

... Matsuura T, Kawada M, Hasumura S, Nagamori S, Obata T,Yamaguchi M, Hataba Y, Tanaka H, Shimizu H, Unemura Y, NonakaK, Iwaki T, Kojima S, Aizaki H, Mizutani S and Ikenaga H High den-sity culture ... measuring the radioactivity in the pellet and supernatant that was obtained after cen-trifugation of the media. Cell- associated ligand was quan-tified by measuring the amount of radioactivity releasedby ... α-mannosidase wasdetermined after intravenous administration of traceamounts of 125I-tyramine cellobiose-FSA (125I-TC-FSA)and 125I-α-mannosidase. Decay plots indicated efficientclearance...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... nuclearextracts were incubated with avidin–agarose beads (Sigma)at 4 °C for 30 min to eliminate materials in the extracts thatbind nonspecifically to the beads. After removing the beadsby filtration, ... suggest thatthe Ku proteins that bind specifically to MREa play animportant role as a basal regulator of WD gene transcrip-tion.MATERIALS AND METHODS Cell cultureThe human hepatoma cell line HepG2 ... for 30 min at25 °C. After elinimating by centrifugation denatured pro-teins generated during the binding reaction, the mixture wascombined with 20 lL avidin–agarose beads and incubatedat room...
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báo cáo hóa học:

báo cáo hóa học:" Triple-Nucleoside Analog Antiretroviral Therapy: Is There Still a Role in Clinical Practice? A Review" docx

... data again show that a t-NRTI regimen that contains a thymidine analog with 3TCand ABC has virologic efficacy comparable to that of a PI-based regimen, but inferior to that of an EFV-based ... al.: Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretro-viral-naive HIV-infected adults: A randomized equivalencetrial. JAMA 2001, 285:1155-1163. Abstract10. Vibhagool ... Mendonca J, Timerman A, et al.: Kaletra vs nelfinavir in antiretroviral-naive subjects: Week 60 comparison in a phase III, blinded, randomized clinical trial. Program andabstracts of the 1st International...
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Báo cáo y học:

Báo cáo y học: " Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock" docx

... os-ingDIC,wechosetomeasureD-Dimerasamarkerofcoagulation in this study as it is widely available, a cor-relate to the pro-inflammatory cytokine levels, and a valuable screening marker for organ failure and mortal-ity ... caspases can activate caspase-3 in the common pathway resulting in final cell death.Caspases are pro-apoptotic proenzymes that inactivateprotective proteins and contribute to cell death by ... inflammation [51].Apoptosis is initiated by two pathways: 1) a receptoractivated, caspase-8 mediated (extrinsic) pathway; and 2) a mitochondrial initiated caspase-9 mediated (intrinsic)pathway. Either...
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Báo cáo y học:

Báo cáo y học: " Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin– angiotensin system in inflammation" potx

... the in ammatory actions of Ang II.ACE and ACE2 are both chloride-activated metallo-peptidases that are predominantly associated with the cell membrane and are widely distributed in various ... the renin–angiotensin system – and speci cally the angiotensin-converting enzyme (ACE)–angiotensin (Ang) II–AT1 receptor axis – may play a prominent role to promote in ammation and  brosis. ... culty of obtaining a consistent measure ment of the enzymatic activity.  e current study reveals a potentially novel mechanism to attenuate the catalytic activity of ACE2, thereby promoting...
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Báo cáo y học:

Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt

... hemorrhage and coagulopathy in critical care patients carries significant morbidity andmortality, with increased incidence of respiratory failure andrenal failure as well as multiple organ dysfunction. ... uppergastrointestinal bleeding. Despite adequate and aggressiveresuscitation and medical management, he continues tohemorrhage. Administration of FVIIa is certainly warranted in this patient. Life-threatening ... mortality in trauma.rFVIIa is efficacious in many but not all circumstances. Apartfrom ongoing bleeding, even off-label use demandsreasonable expectation of benefit. Ongoing bleeding andreasonable...
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