Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... to increasing intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase ... lungs before any increase in proinflammatorycytokine protein occurs, and they further suggest that NF-κBactivation may represent an initial event in the proinflammatorysequence induced by hyperoxia. ... effects of lisofylline on the activa-tion of NF-κB and CREB, on the expression of proinflamma-tory cytokines in the lungs and on the circulating levels of oxidized free fatty acids were examined,...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription factors ... lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an I κ B-αα/NF- κ B-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolarepithelium. ... injury.Inflammatory reactions and lung injuryMechanical ventilation and NF- κ B-mediated lung injurySome unprecedented conditions may occur during the evolu-tion of the inflammatory process,...
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Báo cáo y học: "Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes" pot
... adipocytic/fat-storing mesenchymal cells and loss of thymocytes with advancing age lead to a novel con-ceptual point of view concerning the understanding of the process of thymic physiology in ... observed in thymocytes and in mul-tilocular cells in the septa and inside the thymic pa-renchyma. These data reinforced the hypothesis that adipocytic mesenchymal cells could be possibly im-migrating ... by the age-associated increases in the staining of thymocytes and microenvironmental cells, including the multilocular fat-storing cells. These data suggest that chemokines may influence the...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc
... V3pituitary and oxytocin receptors, and the P2class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions ... G-proteins of the Gq/11 family. The α-subunits regulate the activ-ity of the β-isoforms of phospholipase C [29]. A variety of signaling pathways is associated with the V1R, and thesepathways include ... excretionfrom the kidney by increasing the osmotic water permeability of the renal collecting duct – an effect that is explained bycoupling of the V2R with the Gssignaling pathway, whichactivates...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps
... vasopressininteraction in these pathways. We discuss the seemingly con-tradictory studies and some new information regarding the actions of vasopressin on the heart. Finally, we summarize the clinical ... vasodilation of others.Vasopressin and the heart The actions of vasopressin on the heart are complex and the studies are seemingly contradictory. Depending on the species studied, the dose used, and the ... independently of coronary blood flow, the effects of vasopressin on inotropy were strikingly different. By main-taining constant coronary flow, the direct cardiac effects of vasopressin on an isolated...
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Báo cáo y học: "Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis" potx
... Sweden) and the bands were revealed bysilver staining. The gels were scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft-ware (BioSystematica, Plymouth, UK). The ... for assigning the patients to various categories, we set the intensity of the 676-bp band of the molecular mass marker on eachgel as the arbitrary cutoff point (Fig. 1, arrow). The intensityFigure ... the type of inflammation seen in mtDNA-injectedmouse joints. It is also worth emphasizing that the process of inflammation in RA joints is dynamic, with the infiltration of new inflammatory cells,...
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Báo cáo y học: " Overlapping enhancer/promoter and transcriptional termination signals in the lentiviral long terminal repeat" doc
... biology studies.LJC conceived the study. LJC, SS and AL initiated the design of the study and QY performed the statistical anal-ysis. LJC and QY participated in the final figure prepara-tion and ... silenced the expression of NFκB in TE26 using lentiviral siRNA targeting the p50 of the NFκBdimer and compared the readthrough efficiency of SINLTR, WT LTR and U3C LTR in both control and NFκB-silenced ... nt of U3C.Analysis of key termination signals contributing to LV RNA readthroughU3C contains NFκB and Sp1 binding sites and TATA box.To dissect the role of these transcription factor bindingsites,...
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Báo cáo y học: "Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation" doc
... secondarily in uences IAP/IAH is likely to greatly in uence respiratory mechanics and outcomes. Further study of the role of IAP/IAH in the physiology and outcomes of PV in hypoxemic respiratory failure ... IAH and intra-abdominal volume or thus the compliance of the abdominal wall, and of the potential di erence in the abdominal in uences between the extrapulmonary and pulmonary forms of acute ... pulmonary and extrapulmonary – refl ecting either direct lung injury or indirect injuries to the pul monary endothelium as mediated by the systemic in am matory response [20,21]. In particular, the...
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Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
... of catecholamine dysfunction and refractory hypotension [5].Downregulation of catecholamine receptors occurs withprolonged use of exogenous catecholamines and this may bereversed with administration ... 60-year-old man has been in your intensive care unit withseptic shock for 5 days and he has required a norepinephrineinfusion for the entire time. He had multisystem organ failurebut most of ... Simone†‡, Randy Wax§¶, Katherine G Craig** and Keith R Walley††*Resident, Department of Medicine, University of Toronto, Canada†Resident, Division of Thoracic Surgery, University of Toronto,...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt
... Cohn41Professor and Chief of Intensive Care and Accident Department, University Hospital Maastricht, The Netherlands2Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands3Fellow ... sepsis and mortality. They included a study by Luiten and colleagues[8], which used selective decontamination of the digestivetract. Selective decontamination is attractive as it may allow the ... decont-amination of the gastrointestinal tract for the purpose of pos-sibly decreasing bacterial inoculation of the necroticpancreatic tissue via translocation [8]. One hundred and twopatients...
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