... 30–32% for polyamide and AN69, and
of 0% for cellulose acetate and polysulfone. IL-1 adsorption
Commentary
Hemofiltration, adsorption, sieving and the challenge of sepsis
therapy design
Patrick ... sepsis. Hemofiltration has been proposed as a therapy for
sepsis based on its ability to remove circulating IM by sieving or
by adsorption, or both. Designing devic...
... since they are
rapidly hydroxylated by oxygen-dependent HIF prolyl-4-
hydroxylase domain enzymes (PHD), subsequently
captured by the ubiquitin ligase Von-Hippel-Lindau
protein (VHL), and degraded ... cross-talk of HIF and other key regulators of
gene expression (STAT, p-300 and others), further
modifi cation of HIF-α activity at the level of DNA hypoxia-
responsive eleme...
...
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Sara Perry obtained her BSc in Microbiology and Immunology from University of
Leeds, and PhD in Immunology from University of Liverpool, where she worked on the
expression of HLA-DR ... expression of both the percentage of monocytes expressing HLA-DR and the density of
HLA-DR expression have been observed as a feature of...
... in the mitochondrial and
cytosolic fractions, and in the whole liver homogenate. The
enzyme activity of mitochondrial AAT in the cytosol was
determined as described by Greco et al. [16]. Brie y, ... PH, the activities of the enzymes
released in the supernatant (1.8 ± 0.1 and 0.8 ± 0.04% of
the total mitochondrial activity of GDH and AAT,
respectively), were as...
... machinery, allowing the formation of glutathione (GSH) by the action of the rate-limiting enzyme, γ-glutamylcysteine synthetase (γ-
GCS). The activity of γ-GCS is irreversibly blocked by L-buthionine-(S,R)-sulfoximine ... death, on the other hand, is relatively quick
and violent, characterized by the swelling of the cytoplasm,
the rupturing of cell membranes, the...
... considered other characterized
TFs and putative, as yet uncharacterized regulators. We ana-
lyzed the history of each of the global regulators, and of a sam-
ple of each of the other types of regulators ... grows more rapidly than the size of
the network. However, because only 13% of the TFs evolved
by duplication within the E. coli lineage, and because th...
... occupancy is either the cause or the result of the
transcriptional status of a gene.
This raises an important question: what are the determi-
nants of nucleosome occupancy, and how do they relate ... regulatory regions of the yeast genome have a lower density of
nucleosomes than other regions, and that there is an inverse correlation between nucleosome
density and...
... pulmonary sepsis, suggesting
that the eff ects of hypercapnic acidosis depend not only
on the stage of the infective process, but also on the site
of the primary infection.
Early systemic sepsis
Hypercapnic ... issues
underline the importance of understanding the eff ects of
hypercapnia on the immune response, and the implica-
tions of these eff ects in th...
... risk of
recurrence, case-fatality rate of stroke, probability of dis-
ability after stroke, and the four probabilities of death -
affect patients’ courses in the same way as they did in the
original ... performed the analysis and drafted the
manuscript. JvE provided data and details on the EDISSE study and edited
the draft manuscript. MD helped with the clinica...