Báo cáo y học: "PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse" ppt
Báo cáo y học: "PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse" ppt
... AccessResearchPPARα downregulates airway inflammation induced by lipopolysaccharide in the mouseCarine Delayre-Orthez1, Julien Becker1, Isabelle Guenon2, Vincent Lagente2, Johan Auwerx3, Nelly Frossard1 ... chemokineexpression by lipopolysaccharide in vitro and in vivo. JImmunol 1999, 163:1537-1544.6. Goodman RB, Pugin J, Lee JS, Matthay MA: Cytokine-mediated inflammation in acute lung injury. Cytokine ... sug-gesting that PPARα may also play a beneficial role in tissue remodeling [24,25].We have here investigated the role of PPARα in a mousemodel of LPS -induced airway inflammation characterizedby...
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Báo cáo y học: " Isolation of a new HIV-2 group in the US" pptx
... for review by the Editor -in- Chief of Retrovirology.Competing interests The authors declare that they have no competing interests.Authors' contributionsSMS conceived of the study, designed ... resulting in neither disease nor horizontaltransmission.Furthermore, the commercial assay for establishing the existence of active infection, namely PCR for HIV-2 provi-ral DNA, did not detect the ... determine the extent of this virus' spread in SierraLeone and to other countries.ConsentVerbal consent was obtained from this patient by SMS. The consent was witnessed by VDL. The consent...
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Báo cáo y học: " Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD" potx
... emphysema.However, the influence of smoking and its cessation on airway inflammation and MMP-12expression during COPD is still unknown. We aimed to analyse airway inflammatory cell patterns in induced ... that inflammation initiated by smoking leads to a changes in both – airways and lungparenchyma. The main known contribution of smoking isactivation and recruitment of inflammatory cells to the lungs ... the slides were incubated with biotinylated secondary anti-body (Santa Cruz, USA) for 30 min. Followed by wash-ings in PBS, slides were incubated with avidin-biotinylated peroxydase (Santa Cruz,...
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Báo cáo y học: " Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes" ppsx
... expression in bovineand human OA chondrocytes. Mithramycin dose-dependentlydiminished these inductions.TNF-α -induced MMP gene expression is inhibited by mithramycinTNF-α is another prominent inflammatory ... prevents the binding of Sp1 to its cognateDNA [19]. MMP-3 and MMP-13 induction by the three majorinflammatory cytokines and inhibition by mithramycin imply thatinterference with Sp1 binding might ... Interestingly, a tetracycline analogue,doxycycline, downregulated the TNF-α -induced expression ofMMP-13 RNA in human chondrocytes [33]. Similarly, tetracy-cline also reduced the IL-1-induced...
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Báo cáo y học: " Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium" doc
... Hirota JA, Budelsky A, Smith D, Lipsky B, Ellis R, Xiang YY, Lu WY,Inman MD: The role of interleukin-4Ralpha in the induction of glutamicacid decarboxylase in airway epithelium following acute house ... 15 The data demonstrate there is expression of genes for acomplete GABAergic system in the airway epithelium.Interestingly, the expression of GAD67 was markedlymodified by smoking, with increased ... to healthy nonsmokers, afinding confirmed at the mRNA level by TaqMan PCR;and at the protein level qualitatively by immunohisto-chemistry, and quantitatively by Western analysis. Therewas...
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Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx
... may be spoiled by inaccuratepositioning of the interacting groups. The contact area of the distamycin amidinium end wasinvestigated by evaluating the hydrogen positions andinteraction energy ... These confirmed that in the refined crystal geometry the drug is rather too tightlypacked against the G19 base. The interaction can beimproved by locally relaxing the drug geometry, but nohydrogen ... AT-rich sequences [1],thereby preventing DNA and RNA synthesis by inhibitionof the corresponding polymerase reaction. The crystalstructure determination of a 1 : 1 distamycin–d(CGCAAATTTGCG)...
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Báo cáo y học: "Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes" pot
... by the age-associated increases in the staining of thymocytes and microenvironmental cells, including the multilocular fat-storing cells. These data suggest that chemokines may influence the ... simply fill a space left by the thymic lymphoid compartment or replace the lymphocytic perivascular space. In the present study, we defined not only thymic unilocular adipocytes in the thymus ... cells in the septa and inside the thymic pa-renchyma. These data reinforced the hypothesis that adipocytic mesenchymal cells could be possibly im-migrating and/or differentiating in the aging...
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Báo cáo y học: "Clinical use of a modified release methylphenidate in the treatment of childhood attention deficit hyperactivity disorder" pps
... impulsivity. The P4 was designed by one of the consultant child psychiatrists in the team and has been in use for 15 years as one of the tools available for screening the core symptoms of ADHD. The ... used in everyday clinical practice are needed. Challenges in clinical practice In the specialist ADHD clinic in East and North Hertfordshire, UK, assessment is by use of the P4 screening ... atomoxetine, are licensed in the UK for the management of ADHD in school-age children and young people, and are effective in controlling ADHD symptoms [9]. The guidelines produced by the UK...
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Báo cáo y học: "Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes" ppt
... localised in the lining layer. Second, FAP expression by RA FLSs is mainly by FLSs of the myofibroblastic phenotype. Third, RA jointsshow an accumulation of MMP-1 and MMP-13, in concert with the v3 ... andchronic inflammation of the synovial membranes that invadedeeply into the articular cartilage and bone. Activated fibrob-last-like synoviocytes (FLSs) in the lining layer of the synoviumare ... FAP-expressing cells as the centre of highinflammatory activity in the rheumatoid synovium (Figures 4and 5). In contrast to the synovial lining layer of rheumatoidjoints, osteoarthritic joints show...
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Báo cáo y học: "Utilization and spending trends for antiretroviral medications in the U.S. Medicaid program from 1991 to 2005" docx
... (Aptivus®, the latest entry to the PI class in 2005quarter 3). (Neither of these drugs is featured individuallybut contributes to the category "Other PIs.") Similarly to the NRTIS, the later ... priceincreases of drugs once they are being marketed. The first factor driving the increase in Medicaid prescrip-tions over the past decade and a half is the move frommonotherapy to combination ... from 37 percent in Texas to almost 70 percent in New Jersey [22,23].Secondly, rising utilization can be explained by decliningmortality rates, leading to individuals' requiring more pre-scriptions...
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