Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant(tobacco) protein [7,8]. In Drosophila, Toll is involved in therapid and transient ... regions ofToll and 18W contain multiple leucine-rich repeats and carboxyl-terminal cysteine-rich domains [12].DrosophilaToll signaling pathwayCurrent understanding of the Toll pathway in Drosophilaimmune ... Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC,Podolsky DK: Lipopolysaccharide activates distinct signalingpathways in intestinal epithelial cell lines expressing Toll-like receptors. J Immunol...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... 98:281–284.2. Yan SF, Tritto I, Pinsky D, Liao H, Huang J, Fuller G, Brett J, May L,Stern D: Induction of interleukin 6 (IL-6) by hypoxia in vascularcells: central role of the binding site for ... cellular interactions. Biochim Biophys Acta 2000, 1497:1–10.An excellent review of EC–leukocyte interactions involved in vascular inflam-matory responses to hypoxia.7. Yan SF, Zou YS, Gao Y, Zhai ... Lawson CA, Yan SD, Yan SF, Liao H, Zhou YS, Sobel J, Kisiel W,Stern DM, Pinsky DJ: Monocytes and tissue factor promote throm-bosis in a murine model of oxygen deprivation. J Clin Invest 1997,99:1729–1738.9....
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Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx
... these cytokines are exceedinglycomplicated. Together, however, they act to alter coagula-tion, induce fever, and cause hypotension and tissue injury,as is widely observed in septic shock. In part, ... within the past4 years in our understanding of how cytokine storm is elicitedduring severe infection offer a good deal of promise. Althoughsuccess in treating sepsis with individual cytokine inhibitorshas ... the innateimmune system, including the macrophage and the dendriticcell, are also active phagocytes, and are quite capable ofReviewScience review: Key inflammatory and stress pathways in criticalillness...
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Báo cáo y học: "Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury" potx
... kidney injury↓ Cisplatin-induced kidney injury2C11 ↓ Uranyl nitrate induced kidney injury2D2 ↔ Nephrectomy↔ Bilateral ureteral ligation↔ Glycerol-induced kidney injury↔ Cisplatin-induced ... purposes)change in CYP activity in the intestine and liver may notnecessarily be the same. Specifically, during glycerol-inducedAKI in rats, there was a significant increase in CYP3A4activity in the intestine ... is usually clearedby hepatic metabolism to N-formylaminoantipyrine and N-acetylaminoantipyrine. However, the rates of appearance ofN-formylaminoantipyrine and N-acetylaminoantipyrine werealso...
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Báo cáo y học: " Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice" pot
... strictly necessaryfor increased protein leakage during endotoxemia. In a studyof rats given endotoxin by continuous infusion, fucoidin, aselectin-binding carbohydrate, blocked leukocyte adhesionbut ... involves actin-myosin inter-action and changes in intracellular calcium, and passive cellu-lar retraction, which probably involves protein kinase Cphosphorylation and actin linking at intercellular ... main finding of the present study was a disjunctionbetween leukocyte adhesion and vascular leakage; leukocyterolling and adhesion was increased in septic mice both with and without iNOS induction,...
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Báo cáo y học: "Evolutionary conservation of sequence and secondary structures in CRISPR repeats" pps
... The study of CRISPRs is in its infancy, and their mode and function is still highly speculative. Ourresults provide another step toward a comprehensive under-standing of these intriguing elements.Materials ... CRISPR/CAS system participates in an antiviralresponse, probably by an RNA interference-like mechanism.The proposed mechanism for this CRISPR function involvessampling and maintaining a record of invasive ... Makarova KS, Grishin NV, Shabalina SA, Wolf YI, Koonin EV: A puta-tive RNA-interference-based immune system in prokaryo-tes: computational analysis of the predicted enzymaticmachinery, functional...
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Báo cáo y học: "A review of anatomical and mechanical factors affecting vertebral body integrit
... loads in vertebrae, particularly in vertebrae with altered extrinsic and intrinsic structural integrity. Peak loads in individuals will vary due to differences in activity levels and incidences ... around the spine and trunk are responsible for providing controlled movement and stability. Maintaining controlled movement and stability in the trunk may minimise the risk of sustaining a vertebral ... dense anteriorly and superiorly and more dense posteriorly and inferiorly with heterogeneity between symmetric sites within the vertebral body [2, 3, 25, 56, 67, 78]. The lower density and therefore...
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Báo cáo y học: "Systematic review of safety and tolerability of a complex micronutrient formula used in mental healt" pptx
... vitamins,16 minerals, 3 amino acids, and 3 antioxidants.) Thereare currently 12 publications on EMP+ in the psychiatry and psychology literature, and other research is underreview and in progress. ... treatmentinformation, and two large database analyses are suffi-ciently promising to suggest that the formula may havesome efficacy in the treatment of mood and anxietysymptoms in both adults and ... amounts and combinations of nutrients they contain. As these complex formulaeare being studied and used clinically with increasing frequency, there is a need for direct evaluation of safety and tolerability.Methods:...
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Báo cáo y học: " Household exposure to pesticides and bladder exstrophy in a newborn baby boy: a case report and review of the literature" pps
... respiratory mucosa and conjunctivathan pyrifoxen and explain the mother’s symptoms [11].The qualitative method which we used was capable ofdetecting pyrethroids and pyriproxyfen in the child’s urine.Pyriproxyfen ... thespray increased. Duri ng gestational weeks 0–12, themother intensively used the domestic pesticide consistingof a mixture of pyrethroids (cyfenothrin 0.5% and tetramethrin 0.31%) and p yriproxyfen ... continuum,representing different levels of severity within the samespectrum [10]. Before the 5thweek of embryonic devel-opment, the urinary and gastrointestinal tracts and genitals drain into a common...
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Báo cáo y học: " Equipment review: Pulmonary uptake and modes of administration of inhaled nitric oxide in mechanically-ventilated patients" ppt
... inspiratory NOconcentration. As shown in Fig 7, any change in thepatient’ s inspiratory drive resulting in variations in tidal volume, inspiratory flow and duration inducedfluctuation in inspiratory ... varied by more than 200% as a function of varying tidal volume and inspiratory time. A decrease in the tidal volume or an increase in the inspiratory time was associated with an increase in the inspired ... concentrations in the inspiratory limb are fairly stable during seque ntialadministration both in the lung model and in patients.Since a constant inspiratory flow is delivered from boththe NO cylinder...
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