Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
Báo cáo y học: "What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years" doc
... struc-tures within the joint, including the ability to clearly depictsynovitis following the administration of the MRI contrastagent gadolinium-DTPA (Gd-DTPA) [8]. Ultrasound alsobrings with it excellent ... autonomous of inflammation[5]. At the dawn of the era of biological therapy in RA, thistheory led to the concept of a dual-therapeutic strategy,including anti-inflammatory biological therapy, on ... final common pathway of an array of inflammatory, crystal, and degenerative arthritis. The advan-tage of seeing patients early in the course of disease is thatabnormalities evident in imaging...
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Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
... Corticosteroids can regulate the synthesis and function of catecholamines and their receptors, which in turn control vascular tone and organ perfusion [4].Proinflammatory cytokines released in sepsis alter ... leading to the deleterious effects of catecholamine dysfunction and refractory hypotension [5].Downregulation of catecholamine receptors occurs with prolonged use of exogenous catecholamines and ... hormone.Available online http://ccforum.com/content/6/2/113A 60-year-old man has been in your intensive care unit with septic shock for 5 days and he has required a norepinephrineinfusion for the entire...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt
... University Hospital Maastricht, The Netherlands2Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands3Fellow in Trauma and Surgical Critical Care, University of Miami ... associated with catheter sepsis).Lutien and colleagues more recently used intravenous and enteral antibiotics (including amphotericin) to achieve decont-amination of the gastrointestinal tract for the ... important in the management of patients with pancreatitis with evidence of pancreatic necrosisLorne H Blackbourne and Stephen M CohnLimiting prophylactic antibiotic use in severe pancreatitis min-imizes...
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Báo cáo y học: "Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers" ppt
... mild hypokalaemiamay offer benefit by promoting cellular calcium entry and increasing the inotropic effect of insulin [21,24].Recommendations for the use of HIET in CCBpoisoningAlthough there ... variation in insulin dosing in the casesreporting the use of HIET in CCB overdose and in the duration of treatment, rational recommendations couldcurrently consist of the administration of 1.0 ... suggesting a potential benefit of HIET in β-adrenergic blocker toxicity are discussed; clinical data are currentlylacking.IntroductionHyperinsulinaemia/euglycaemia therapy (HIET) consists of the...
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Báo cáo y học: " HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain" doc
... oligomer formation is essential for Rev activity by assessing the requirements for restora-tion of the activity of the mutant.Results The intracellular localization of Rev and mutants The intracellular ... specific binding of Rev to RRE [3,9-11]. An other essential domain (aa 75–84) signals activenuclear export of Rev (NES) [8,12-14]. The Rev basicdomain binds with high affinity to a site within the ... corresponding to the basic domain of Rev inhibited the in vitro splicing of RRE containing mRNAs underscores the functional importance of this region [39,40]. Theseresults therefore support the suggestion...
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Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf
... DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TOGENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW; THE ONLY REQUIREMENT IS AN EXPLICIT CITATION OF, AND LINK TO, THE PREPRINT IN ANY ... preference of the reverse transcriptase enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing the chance of oxidation and / or bleaching. The main contributing ... determined from VSG The variance of S1 versus the pooled S2 and S3 (S=1v23) in the VSG interaction decreased with 16.1 % to 14.9 %, with the variance in the VG interaction remaining virtually techniques...
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Báo cáo y học: "Th2 cytokines and asthma: an introduction Peter J Barnes" pps
... the recognition that cytokines play a critical role in orchestrat-ing, perpetuating and amplifying the inflammatoryresponse in asthma. Indeed the increased and abnormalexpression of cytokines ... involved in the pathophysi-ology of asthma [1,2]. While some of these cytokines, such as interleukin (IL)-1, tumour necrosis factor-α and IL-6, are involved in many inflammatory diseases, includingchronic ... secreteIL-2 and interferon-γ, although the clear distinctionbetween Th1 and Th2 cells is not as distinct in humans as in mice. Th2 cytokines may play an important role in the pathophysiology of allergic...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... differentiation. The induction of TH2-likeReview Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonistsJohn ... heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain. Binding of IL-4 results in the tyrosine phosphorylation of signal trans-duction molecules including motifs ... chains of the heterodimer are required to initiateintracellular signaling. (b) The sIL-4R consists of the extracellular portion of IL-4Rα. It retains the ability to bind IL-4 with high affinity...
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Báo cáo y học: " Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease" doc
... antibody with specificity for human and primateinterleukin-5 [109,110].SCH55700 has an affinity for human interleukin-5 of 81 pmol/l and a 50% inhibitory concentration for inhibition of human interleukin-5-mediated ... interleukin-5-induced hyperreactivity wasabated by blocking the activity of interleukin-1, and interleukin-1β mRNA and protein levels are increased byinterleukin-5. Interleukin-5 may contribute to airway ... a type-1 cytokine receptor for inter-leukin-5 with a specific α-subunit and the βc-subunit thatconfers high-affinity binding and signal transduction. Aspecific inhibitor of interleukin-5...
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Báo cáo y học: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma" ppsx
... inhibit the activity of IL-4 and IL-5 [11]. However, the crucial roles of these factors in supporting the normal biology of specific cell typesReview Th2 cytokines and asthma Interleukin-9 as a therapeutic ... helper type 2 (TH2) lymphocytes, and the cytokines that they produce, in the pathogenesis of allergic asthma [4,5]. Other forms of asthma include thoseinduced by exercise, viruses, aspirin, and ... occupation. The mechanism underlying these forms of asthma might simi-larly involve TH2 lymphocytes and cytokines but might betriggered differentially by airway epithelium damage causedby viral infection,...
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