... in the ARDSNet trial. Clearly, the greater
the difference in the independent variable, the greater the
commentary
review
reports primary research
Commentary
Mechanical ventilation: lessons from ... mortality
by simply addressing the injury imposed by overstretching
the lung. Why was this trial positive when other similar
trials were negative?
One possible reason coul...
... ultimately leading to autocycling
in the case of a flow trigger. Given the frequency of auto-
cycling in the ICU, this information may be applicable to
other patients who are mechanically ventilated. ... which
may then trigger an autocycled breath if timed correctly.
Conclusion
In summary, autocycling of the mechanical ventilator
occurred in 50% of patients who had received TAHs wit...
... those cytokines. Therefore,
their study also suggests that TLRs play a role in the
inflammatory response initiated by MV in healthy lungs.
Our study is complementary to a study by Moriyama et
al ... to cytoplasmatic and
nuclear staining of epithelial type II cells and interstitial macrophages surrounding the alveolus, respectively. The inflammatory infiltrate with
monocytes and lymphocy...
... and RH hospi-
tals, the make up of the physician team was very different.
With the exception of one RH, pulmonary specialists were
found exclusively in the RRHs. Family physicians,
general internists ... transferred
to the tertiary setting, 12 (60%) survived.
One hundred and twenty-five patients (56%) were admit-
ted from the emergency room, 73 (33%) from general
wards and 26...
... least 5 years old, making
several of the sections slightly dated. Second, the book is
written by respiratory therapists for respiratory therapists, and
several of the sections (e.g. on the basics ... makes the book easy to read. There are many
anecdotes, especially in the first section, that had me
chuckling.
As for any textbook, there are limitations. First and foremost is
the...
... ALI/
ARDS (by definition) [8,9]. Second, patients may not yet fulfill
consensus criteria at the initiation of MV but they may develop
ALI/ARDS during the course of their disease. Third, critically ill
patients ... University of Amsterdam, Amsterdam, The Netherlands
2
Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The...
... to
study the pathophysiological mechanisms behind VILI and the
contribution of MV to lung injury in the absence of pre-existing
lung injury.
Competing interests
The authors declare that they have ... obtained from the right
lung; the left lung was used to measure the wet-to-dry ratio. In
a second series of mice (n = 6), blood was sampled from the
carotid artery for blood g...
... the study, performed the statistical analysis, and
wrote the first draft of the paper. RG performed the immuno-
histochemistry and morphometrical analysis, and performed
the statistical analysis. ... and
the number of macrophages and PMNs is in line with these
observations. The low number of lymphocytes in the heart of
our study may be explained by the observation of incre...
... lung injury might be not caused directly
by the mechanical forces, but by the mediators pro-
duced in response to these forces [36,37]. Therefore, the
interaction between increased cytokines levels ... end-
expiratory pressure (ZEEP) induces not only cytokine
release but also translocation of cytokines from the lungs
to the systemic circulation and even vice versa [5-7]. The
c...
... rate. The following data on
relevant systemic factors were also collected: year of data
collection, time of day (day, evening, or night-shift),
whether weaning was prescribed by physician and
whether ... (weaning prescribed by a physician) was
analysed as a systemic factor.
Ethical considerations
We collected data from the ICU quality assurance data-
base as well as ICU patient charts....