... and bone.Given the success of anti-TNFα therapy, there has been agreat deal of interest in elucidating the pathways driving the production of this cytokine as well as other inflammatorymediators ... member of the TNF superfamily and, corres-pondingly, RANK belongs to the TNFR superfamily. The discovery that RANKL-RANK signalling is the key molecularevent in osteoclast differentiation by several ... of innate immune cells, such as macrophages and synovialfibroblasts, in the progression of disease, as they producelarge amounts of pro-inflammatory mediators leading to the destruction of the cartilage...