... Mitra AK, Radjabi AR, Bhaskar V, Kistner EO, TretiakovaM, Jagadeeswaran S, Montag A, Becker A, Kenny HA, Peter ME, Ram-akrishnan V, Yamada SD, Lengyel E: Loss of E-cadherin promotesovarian cancer ... chromosomal gain and amplifications weremainly confined to the late-stage ovarian tumors [33].Early EOC may therefore already possess genetic abnor-malities that are further propagated in advanced ... [116].Targeted therapy to advanced disease and cancer stem cells The rate of mortality in ovarian cancer has changed littlein the past three decades [1,2]; drug resistance remains the major therapeutic...