Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
... domain has ATPase activity and facilitates self-oli-gomerization. At the amino-terminal a protein-protein inter-action mediating caspase-recruitment domain (CARD) is localized (one CARD domain ... IRAK1, IRAK2, TRAF6 as well as NIK (NF-κB-inducing kinase), TAB2 (transform-ing growth factor-β activated kinase binding protein) and TAK1 (transforming growth factor-β activated kinase) in S. ... pulmonary pathogens into account,an exact analysis of molecular mechanisms of disease ismandatory to form a rational basis for the development of innovative interventional procedures in pneumonia. ...
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Báo cáo y học: " Axial torsion as a rare and unusual complication of a Meckel’s diverticulum: a case report and review of the literature" ppsx
... circu-lation, leading to necrosis and perforation [2].Case presentation A 68-year-old Caucasian man presented to our hospitalwith acute, severe abdominal pain. An examination of the patient revealed ... was resected along with an 8 cm flange of ileum that was encompassed within the vascular terri-tory of the inflamed, unhealthy, and friable mesentery.An end-to-end seromuscular, single-layered ... rare, representing less than 1% of cases[11], they may be a potential risk factor. A large review of 1605 cases of complications of MD identified only 24cases [9]. A variety of benign and malignant...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... insightsinto the mechanisms of protein maturation, folding, and stabilityYoshihiro Sambongi1, Susumu Uchiyama2,*, Yuji Kobayashi2, Yasuo Igarashi3 and Jun Hasegawa41Graduate School of Biosphere ... we have gained insight into the molecular mechanisms underlying cytochrome c maturation and folding as well as stability. Bacterial cytochrome c hascontributed greatly to our understanding in ... from rapidly increasing X-ray crystal and NMRanalyses, have stimulated mutagenesis studies, which con-tribute to the understanding of the mechanisms underlyingprotein maturation, folding, and...
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Báo cáo Y học: Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes docx
... 2035isomerization of aspartate residues [6]. Major targets of these alterations, also called Ôprotein molecular fatiguedamageÕ [7], are cytoskeletal components, such as ankyrin and bands 4.1 and 4.2, as ... fromL-asparaginyl deamidation and/ orL-aspartylisomerization reactions [7]. In addition it has been reportedthat isoaspartate residues, detected by the PCMT in situassay, increase in membrane ... proteins,catalysed by PCMT, is increased as erythrocytes age in thecirculation [6,25,26]. This has been related to an increasednumber of abnormal aspartate residues, spontaneouslyarising fromL-asparaginyl...
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Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
... inflammatorydiseases initiated an era of clinical investigation and estab-lished the foundation of modern clinical immunology. Theoriginal descriptions of antinuclear antibodies by Holman and Kunkel ... (RA), and vasculitic syndromes. Plasmapheresis still has anaccepted role in thrombotic thrombocytopenic purpura and cryoglobulinemia; however, in other chronic inflamma-tory diseases, plasmapheresis ... drug-resistant human B cell lymphomas to thecytotoxic effect of CDDP, VP1- and toxins [abstract]. FASEB J1995, 9 :A2 06.8. Kosmas C, Stamatopoulos K, Stavroyianni N, Tsavaris N,Papadaki T: Anti-CD20-based...
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Báo cáo y học: "Rheumatoid arthritis as a hyper-endoplasmic reticulumassociated degradation disease" pdf
... between syno+/+ and syno+/−mice. No advancedsynovial cell hyperplasia was detected in CIA-syno+/−mice,even though inflammatory cell infiltration was clearly observed in them. Detailed analysis ... functions in the ER-associated degradation (ERAD) system, an essential system for ER homeostasis. Overexpression of Synoviolin in mice causes arthropathy with synovial hyperplasia,whereas heterozygous ... Hada A, Arai M, Wakatsuki T, Matsubara O, et al.: Activation of theATF6, XBP1 and grp78 genes in human hepatocellular carci-noma: a possible involvement of the ER stress pathway in hepatocarcinogenesis....
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Báo cáo y học: "Plasma gelsolin as a biomarker of inflammation" doc
... exposed at the site of overwhelming injury may act as a sink to exhaust the supply of plasma gelsolin, in turn allowing redundant inflammatorycascades unfettered opportunity to wreak havoc uponmultiple ... Identified ligands include platelet-activating factor, lysophosphatidic acid, and sphingosine 1phosphate, as well as cell-wall constituents of Gram-negative and Gram-positive bacteria [6-8]. Actin exposed ... extracellular actin filaments[2]. Hypogelsolinemia ensues after a wide spectrum of seemingly unrelated types of insults and precedes a secondwave of injury that typically involves organs distant...
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Báo cáo y học: "Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study" potx
... the measuring laboratory.Statistical analysisThe data were not normally distributed, so median values and interquartile ranges were calculated as measures of centraltendency; the data are therefore ... follow-up and surveil-lance and often entailing changing treatments. A number of biochemical markers are currently used to clinically assesspatients' disease activity, such as anti-double-stranded ... longitudinal analysis of urinary TWEAK (uTWEAK) and/ orserum TWEAK (sTWEAK) levels as potential biomarkers of LN.The performance of TWEAK as a biomarker for nephritis wascompared with routinely used...
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Báo cáo y học: " Toxoplasmosis presenting as a swelling in the axillary tail of the breast and a palpable axillary lymph node mimicking malignancy: a case report" potx
... this article as: Siriwardana et al.: Toxoplasmosis presenting as a swelling in the axillary tail of the breast and a palpable axillary lymphnode mimicking malignancy: a case report. Journal of ... presenting as a swelling in theaxillary tail of the breast and a palpable axillarylymph node mimicking malignancy: a case reportHP Priyantha Siriwardana1*, Louise Teare2, Dia Kamel3 and E ... few cases have been reported [3-5]. We present a case of toxoplasmosis that presented as an axillary tail(breast) mass and a palpable axillary lymph node whichmimicked breast cancer.Case presentationA...
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Báo cáo y học: " Exploring mentorship as a strategy to build capacity for knowledge translation research and practice: protocol for a qualitative study" pps
... and analysis of interviews. All investigators will assistwith interpretation, report writing, and disseminationactivities, including the culminating workshop. All inves-tigators read and approved ... researchmay increase knowledge about, confidence in, and greaterutilization of KT processes, and the quality and quantity of KT research, perhaps ultimately leading to better imple-mentation and ... politics, and maintaining work-life balance. Participants thought that research mentoringincluded identification of sources of funding, review of grants and manuscripts, and facilitating linkages...
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