Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot
Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot
... intensity by IgG from SSc patients were analysed by using Pathway Studio soft-ware. Interestingly, most of < /b> these proteins < /b> were involved< /b> in < /b> the < /b> transforming < /b> growth < /b> factor < /b> b (TGF -b) pathway (Additional ... this article as: Bussone et al.: Identification of < /b> new < /b> autoantibody< /b> specificities < /b> directed < /b> at < /b> proteins < /b> involved < /b> in < /b> the < /b> transforming < /b> growth< /b> factor < /b> b pathway in < /b> patients with systemic sclerosis. ... patients with unidentified ANAs (Figure 4). Thus, the < /b> express ion of < /b> these proteins < /b> can be either increasedor decreased by TGF -b. Interestingly, some of < /b> these proteins < /b> are involved < /b> in < /b> the < /b> pathophysiological...
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Báo cáo y học: "Identification of possible candidate genes regulating Sjögren''''s syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy" docx
... several of < /b> the < /b> RI lines, thereby retaining the< /b> phenotype of < /b> parental C57BL/6.NOD-Aec1Aec2 mice, whilea number of < /b> the < /b> RI lines also failed to show a loss of < /b> secretoryactivities, thereby indicating ... balance of < /b> IL-6and transforming < /b> growth < /b> factor-< /b> beta influenced by retinoicacid. Thus, the < /b> intricacy and balance between OX40L, the< /b> retinoids, proinflammatory cytokines, and development of < /b> Tregcells ... During the < /b> subsequent inbreeding, wewere successful in < /b> generating 39 new < /b> homozygous Aec2 RIlines. To map each genetic segment of < /b> the < /b> Aec2 regionremaining within each of < /b> the < /b> 39 newly generated...
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Báo cáo y học: "Identification of an endogenous retroviral envelope gene with fusogenic activity and placenta-specific expression in the rabbit: a new "syncytin" in a third order of mammals" ppt
... and the < /b> cellular cytotro-phoblasts, the < /b> labeling profile is compatible with syncytin-Ory1 being expressed in < /b> the < /b> cytotrophoblast just beforefusion takes place and/or in < /b> the < /b> newly formed syncytio-trophoblast ... transduced with syncytin-Ory1. Finally, in < /b> situ hybridization of < /b> rabbitplacenta sections with a syncytin-Ory1 probe revealed specific expression at < /b> the < /b> level of < /b> the < /b> junctional zonebetween the < /b> placental ... have been"co-opted" by their host to participate in < /b> the < /b> formation of< /b> the < /b> syncytiotrophoblast layer, at < /b> the < /b> maternal-fetal inter-face, by mediating the < /b> fusion of < /b> mononucleated cytotro-phoblasts.A...
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Báo cáo y học: "Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia"
... clinical history, and certain laboratory data may guide the < /b> choice of < /b> which endoscopic in < /b> -vestigation to perform first in < /b> patients with IDA, the-< /b> reby, potentially reducing the < /b> frequency of < /b> ... endoscopic investigation to perform first in < /b> patients with IDA (especially in < /b> pre-menopausal women), thereby, potentially reducing the < /b> frequency of < /b> negative findings. It may be an appropriate clinical ... although FOBT posi-tivity is highly dependent on the < /b> locus of < /b> the < /b> bleeding source. Bleeding lesions in < /b> the < /b> GI tract are identified in < /b> about 50% of < /b> patients with IDA [7-8]. Laboratory findings in...
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Báo cáo y học: "Identification of Cellular Membrane Proteins Interacting with Hepatitis B Surface Antigen using Yeast Split-Ubiquitin System"
... prey protein interacts with the < /b> bait protein, this would bind the < /b> NubG and Cub domains together to form the < /b> ubiquitin complex. This complex will then be recognized by UBPs and the < /b> TF that ... system is not suitable for the < /b> analysis of < /b> interaction between membrane bound proteins.< /b> The < /b> split-ubiquitin yeast two hybrid system has been recently developed for the < /b> characterization of < /b> ... Proteins < /b> Interacting with HBsAg A number of < /b> cellular proteins < /b> have been isolated using the < /b> conventional yeast two hybrid screening [10, 11]. However, these reported HBV interacting proteins...
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Báo cáo y học: "Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers" docx
... indicating that the< /b> subpopulations – although exhibiting considerable overlap– are not absolutely identical. The < /b> expression of < /b> triple com-binations of < /b> MPC typical surface markers, combined with the < /b> ... were incubated with 10 ng/ml recom-binant human transforming < /b> growth < /b> factor-< /b> β3 (Tebu,Offenbach, Germany) during chondrogenesis. All cultureswere maintained at < /b> 37°C in < /b> 5% carbon dioxide, and the< /b> medium ... in < /b> PBS. Bioti-nylated anti-mouse, anti-rabbit secondary antibodies wereused for 30 min incubation followed by streptavidin treat-ment (30 min). Finally, sections were stained using the < /b> AECkit...
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Báo cáo y học: "Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies" ppsx
... noinhibiting effect of < /b> the < /b> SmD3 peptide on the < /b> binding of < /b> anti-Sm antibodies to the < /b> native Sm antigen in < /b> ELISA (Varelisa®Sm; data not shown). The < /b> absence of < /b> inhibition can beexplained by the < /b> ... peptide synthesis, non-specific binding sites were blocked by overnight incubation of < /b> the < /b> membranes in < /b> blocking buffer (2% milk in < /b> Tris-buff-ered saline) at < /b> room temperature. After one washing stepfor ... years as containing dimethylated arginines [34]. The < /b> two major catalyzing enzymes of < /b> this reaction are the< /b> type I and type II protein arginine methyltransferases, whichpreferentially methylate...
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Báo cáo y học: "Identification of kinectin as a novel Behçet''''s disease autoantigen" doc
... of < /b> the < /b> kinesin-binding domainis very probably the < /b> most conservative form of < /b> kinectin; it doesnot bind kinesin but act as a membrane anchor for the < /b> transla-tion elongation factor-< /b> 1 delta in < /b> the < /b> ... that are large coiled-coil rich proteins < /b> (≥100 kDa) in < /b> the < /b> cytoplasm.ConclusionHere we report the < /b> detection of < /b> kinectin autoantibody < /b> in < /b> 23% of < /b> Chinese patients with BD. The < /b> identity of < /b> kinectin ... new < /b> inroads into elucidating the < /b> immunopatho-genesis of < /b> the < /b> disease. In < /b> an effort to clarify the < /b> association of< /b> BD with antibody to kinectin, it is essential to measure anti-body to kinectin...
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Báo cáo y học: "Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis" doc
... celllysates were extensively deiminated in < /b> vitro. This isdemonstrated by the < /b> uniform migration of < /b> deiminated enolase at < /b> a pI of < /b> 5 and by the < /b> replacement of < /b> arginine by citrulline in< /b> all the < /b> peptides ... although the < /b> intensity of < /b> the < /b> stainingindicated that levels of < /b> citrullination were relatively low. Immu-noblotting of < /b> synovial cell lysates from three patients with RAdemonstrated that a band ... proteins < /b> in < /b> synovial membranes. (a) Immunostaining of < /b> citrullinated proteins < /b> by the < /b> anti-modified citrulline kit was mainly confined to the < /b> subsynovium. (b) No staining was visible on the < /b> control....
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Báo cáo y học: " Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis" pdf
... isfrequently seen in < /b> the < /b> joints of < /b> patients with RA [27,29], indi-cating that the < /b> gene expression profiles obtained from theseRA models well represent those of < /b> patients with RA. In < /b> addi-tion, many of < /b> ... alternative pathway of < /b> the < /b> complement system. This pathway is also critical in < /b> K/BxN mice, another animal modelfor RA [34]. Although the < /b> alternative pathway typically acti-vated by microbial ... comparison with those seen in < /b> normal joints, byapplying the < /b> principle of < /b> the < /b> SAM method and assuming thatgenes that function during the < /b> effector phase would be simi-larly activated in < /b> both models...
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Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ