Báo cáo y học: "Canakinumab (ACZ885, a fully human IgG1 anti-IL-1b mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)" ppsx
... [http://www.fda.gov/
downloads/Drugs/DevelopmentApprovalProcess/
HowDrugsareDevelopedandApproved/DrugandBiologicApprovalReports/
PriorityNDAandBLAApprovals/UCM090995.pdf].
doi:10.1186/ar3266
Cite this article as: Kuemmerle-Deschner et al.: Canakinumab (ACZ885, a
fully human IgG1 anti-IL-1b mAb) induces sustained remission
in pediatric patients with cryopyrin-ass...
... do
not have it. You don’t have that little paper that says
what is exactly wrong with you. [P5]
Well, I was happy that I finally could, well, give it a
name. That it was truly something. A personality ... transcribed verbatim. Transcripts were analysed in
their original language, Dutch, while relevant quotations
were translated into English for this paper.
Data analysis
Data analysis...
... novel human strain (Pyl43) and STLV-3 isolates
from Cameroon. The virus, that we tentatively named HTLV-3, originated from a 62 years old
Bakola Pygmy living in a remote settlement in the rain forest ... rduprez@pasteur.fr;
Sylviane Bassot - sybassot@pasteur.fr; Alain Froment - afroment@anth.umd.edu; Renaud Mahieux - rmahieux@pasteur.fr;
Antoine Gessain* - agessain@pasteur.fr
* Co...
... José Uriarte, and Fermín
Mayoral for their contribution in the linguistic validation.
Author details
1
Department of Psychiatry, Hospital Universitario de Salamanca, Salamanca,
Spain.
2
Department ... was also examined by computing the intraclass
correlation coefficient (ICC).
Statistical analysis
The sample size was calculated taking into account a
specific objective of calculating multi...
... AGGGACAA-3'
IFN-γ 5'-GAAAGACAACCAGGCCATCAG-3' 5'-TCATGAATGCATCCTTTTTTGC-3'
IL-4 5'-CCACGGAGAACGAG CTCATC-3' 5'-GAGAACCCCAGACTTGTTCTTCA-3'
IL-17 5'-GGGAAGTTGGACCACCACAT-3' ... signal within nor-
mal hypointense area at this site (arrowhead).
Joints of naïve (non-CIA) rats exhibited intact joint architecture.
The talus, phalanges, talocalca...
... 1999,
103:200-202.
8. Kumagai T, Yamanaka Y, Wataya Y, Umetsu A, Kawamura N, Ikeda
K, Furukawa H, Kimura K, Chiba S, Saito S, Sugawara N, Kurimoto F,
Dakaguchi M, Inouye S: Gelatin-specific humoral and cellular
immune ... demonstrated that FG-5001
functioned as an effective live virus stabilizer, maintaining
the titer of a live attenuated influenza strain A/ Sydney
CAZ-002 as well as a...
... medial to lateral part along the anatomical
references lines to enable maxi mum coverage of the ana-
tomical surface area. US Greyscale imaging parameters
were set in order to obtain the maximal ... ultrasound examinations (sonographer 1), prepared the
sonographic images, conducted data evaluation and prepared the
manuscript. FS participated in the statistical analysis and data evaluation...
... Association Panel on Euthanasia)
Table 1
Ventilatory parameters, hemodynamics, and blood gas analysis before and after induction of lung injury
Healthy animal Lung lavage before PCV Lung lavage ... and PCV.
Transpulmonary pressure, pulmonary gas exchange, and
pulmonary shunt
All ventilatory parameters, PaO
2
and PaCO
2
, and calculated
pulmonary shunt fraction data are presented in Table...
... Association Panel on Euthanasia)
Table 1
Ventilatory parameters, hemodynamics, and blood gas analysis before and after induction of lung injury
Healthy animal Lung lavage before PCV Lung lavage ... and PCV.
Transpulmonary pressure, pulmonary gas exchange, and
pulmonary shunt
All ventilatory parameters, PaO
2
and PaCO
2
, and calculated
pulmonary shunt fraction data are presented in Table...
... further increase of IAP (45 mmHg) was accompanied by an increase in mean arterial pressure due to
compensatory tachycardia, followed by an increase in CPP and SPP and a decrease of cytokines and lactate.
Conclusions: ... revealed that animals were hypo-
volemic with an associated tachycardia (Figure 1). Heart
rate initially decreased in phas e T2, but was increased in
the two subs...