... severalhomeostatic systems, leading to alterations in the acid-base balance, blood gases, hepatic perfusion, and cardio-vascular and pulmonary physiology [6]. Frequently,hypercapnia, acidosis, and systemic ... CO2pneumoperito-neum -induced oxidative stress and inflammatory reac-tions by using Erdosteine, a multifactorial drug with antibacterial, anti-inflammatory, and antioxidant proper-ties that can decrease inflammation ... especially neutrophils can increase the systemicavailability of inflamma tory mediators, leading to leuko-cyte activation and endothelial adhesion moleculeexpression and vascular endothelial damage...