... the enzyme responsible for the lastprocessing step of miRNAs, siRNAs are known to beassembled into effector complexes (siRISCs) containingArgonaute proteins as well as Dicer and other factors[3]. ... pre-miRNA processing by siRNAs competing for binding to Dicer, TRBP, and ⁄ or other limiting factors. How-ever, since our northern blot analysis did not reveal aconcomitant increase of pre-miRNAs, ... (pre-miRNA) is then exported to the cytoplasm by a nuclear transport receptor complex,exportin-5 ⁄ RanGTP [7,8]. In the cytoplasm, a secondRNase III, Dicer, cleaves the pre-miRNA to generate the mature...