Báo cáo y học: " Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis" ppt
... of these cells.
Density of neutrophils in synovial tissues of patients with
OA and RA
The presence of HNP1-3 prompted us to study the den-
sity of elastase-positive neutrophils in synovial tissues ... defensins from synovial tissue/ cells and
density of synovial neutrophils. (a) Levels of human neutrophil pep-
tides 1-3 (HNP1-3) in superfusate o...
... degradation. The marked protein is then degraded by
the 26S-proteasome complex, by an ATP-dependent
process. In catabolic states, the activity of the ubiquitin/
proteasome pathway is increased by upregulation ... that involves phospho-
rylation and proteasomal degradation of the NF-κB-
inhibitory protein, Iκ-Bα [13]. NF-κB activity in the cell
nucleus peaks within...
... promotes further expression of
cytokines and chemokines by synovial cells and chondro-
cytes, thereby sustaining a renewal of local inflammatory
mediators (reviewed in [9,10]). The presence of TNF-α ... morphology. The
MAPK/ERK pathway is thereby at least partially involved in
regulating the aggrecan and type II collagen genes and in
remodeling of the cytoske...
... was involved in the design of the study, performed all the
experiments and wrote the manuscript. PB was involved in
performing cell cultures, flow cytometry and gel shift assays,
and reviewed the ... design of the study and reviewed the
article critically. AC was involved in the conception and design
of this study, in the interpretation of data an...
... expression levels of TIARP mRNA and proteins were detected in splenocytes on day 7 (the onset of arthritis). In
joints, the expression of TIARP mRNA and protein was correlated with joint swelling (days ... These
findings suggest that the systemic upregulation of TNFα and
TIARP is involved in the early phase of the disease and that
TIARP expression in arth...
... manuscript critically for important
intellectual content. BK was involved in the conception and
design of the study, analysis and interpretation of the data, and
did most of the drafting of the manuscript. ... van
den: Role of interleukin-1, tumor necrosis factor alpha, and
interleukin-6 in cartilage proteoglycan metabolism and
destruction. Effect of...
... http://arthritis-research.com/content/7/3/R439
123
decrease in the hypervascularity typical of SpA and a
reduction of the synovial lining hyperplasia, indicating that
infliximab also modulates the structural synovial charac-
teristics of the disease. ... acceptable safety
profile in the chronic treatment of rheumatoid arthritis. Not
only did the therapy turn ou...
... abolished the DNA-protein
binding activity induced by HBO. Exogenous addition of
TNF-a significantly increased the DNA-protein binding
activity. To study whether the visfatin expression
induced by HBO ... HBO-induced visfatinproteinexpressionin
human CAECs. Thirdly, JNK kinase and AP-1 transcrip-
tion factor are involved in the signaling pathways of visfa-
tin inductio...
... pyrimidine s for DNA and RNA synthesis and accu-
mulation of AICAR. AICAR, by inhibiting enzymatic
deamination of adenosine and adenosine monopho-
sphate, is proposed to increase availability of ... signaling.
Conclusions: These find ings provide another mechanism by which TNF-a sustains macrophage numbers in
inflamed tissue and identify a further point of clinical com...
... characterized by a chronic
inflammatory process, in which the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α is
considered to play a role. In the present study the putative involvement of TNF-α ...
would further enhance the strength of these kinds of stud
-
ies.
The gene polymorphism of TNF-α +489G/A was de-
scribed for the first time in 1996 and...