... ofcertain transcription factors, the expression of severalpro-inflammatory and anti-inflammatory genes (includingcytokines and cyclo-oxygenase), and the production ofrespiratory mucus [22–34]. In ... Higgs EA: Nitric oxide: physiology, patho-physiology, and pharmacology. Pharmacol Rev 1991, 43:109–142.2. Weinberger B, Heck BE, Laskin DL, Laskin JD: Nitric oxide in thelung: therapeutic and cellular ... formation of RNS bymultiple oxidative pathways, possibly including ONOO–but more probably involving the activity of phagocyte per-oxidases [16,20]. In this regard, a preliminary study with EPO-deficient...