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Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx

Báo cáo y học:

Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx

... Whenexposed to high toxicity, the majority of the cell popula-GPS treatment results in the cytoplasmic release of cyto-chrome CFigure 4GPS treatment results in the cytoplasmic release of cytochrome ... analysis of Annexin V/PI-stained cells To determine the mode of cell death upon GPS treatment,cells were stained with AnnexinV/PI and analysed by flowcytometry, 2 h post-exposure. As seen in ... in turn diluted in the existingair volume in the airways so that the resulting toxicity is not instantly detrimental for the epithelium, or the tissuessurrounding it. Instead, chronic smoking...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc

Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc

... pathway,because of overloading of the SRP pathway. The re-routing of (G-10L)prePhoE to the Sec translocon via the SRPinstead of the SecB pathway could be explained by the increased hydrophobicity of the hydrophobic ... [35]. In general, our results are in agreement with the reported binding of TF to secretoryprecursors [47], but the basis for routing of secretoryproteins to the SecB pathway appears not to be the ... sequence. The signal sequence consists of the positively charged N domain, the hydrophobic Hdomain and the C-terminal C domain. The a-helix in the H domain is predicted to extend up to the Gly at...
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Báo cáo Y học: The reactivity of a-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite pdf

Báo cáo Y học: The reactivity of a-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite pdf

... and the iron complex of octaethylbilindione {(py)2FeIII(OEB)}.Theroleof[(py)2FeIII(OEPO)]+, corresponding to porphy-rin p cation radical of the protohaem system, in this modelsystem ... hydroxylatedat the a-meso-carbon, yielding a-hydroxyhaem. The secondstep is the conversion of a-hydroxyhaem to verdohaemwith the concomitant release of the a-meso-carbon as CO[9]. Finally, the ... d-meso-carbon atoms of the porphyrin macrocycle. These structural featuresprobably direct the a-meso-accessibility of the ferrichydroperoxide that has been demonstrated as the porphy-rin-hydroxylating...
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Báo cáo y học: "The importance of measuring psychosocial functioning in schizophrenia" pps

... since April 2010. AM is a consultant psychiatrist in Oxfordshireaffiliated to the Social Psychiatry Group in the Oxford University Department of Psychia try. VVD is a clinical neuropsychologist ... memory has been proposed to be one of the main predictors of psychosocial functioning, being inde-pendent of gender [27]. This supports the hypothesisthat cognitive variables are better predictors ... improvement in positive symp-toms would automatically lead to improvements in mul-tiple areas of daily living has now been empiricallyrefuted [2].Other symptoms may have more influence on psycho-social...
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Báo cáo y học: "The value of sensitive imaging modalities in rheumatoid arthritis pdf

... imaging of rheumatoid joints permit an increasingly refinedanalysis of anatomic detail. However, further research using these sensitive imaging technologies is required to delineate pathophysiological ... radiography (CR) remain the gold-standardmethodology for assessment of joint damage in RA? The assessment of structural damage by CR relatespoorly to function in early RA, although in disease of 5 years’ ... emphasise the inade-quacy of CR for soft tissue assessment in RA.UltrasonographyRecent studies addressing the use of conventional grey-scale (B -mode) ultrasonography (US) in the evaluation of RA...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps

... diseasepathogenesis of RA (Fig. 1).Role of IL-17 in T cell immunity and/orpropagation of joint inflammation In arthritis, IL-17 is a pro-inflammatory cytokine thought to contribute to the joint inflammatory ... T cells comprise a large proportion of the inflammatory cells invading the synovial tissue. T cell activation and migration into the synovium occur as anearly consequence of disease, and these ... proportion of the inflammatory cellsduring inflammation, T cell- derived cytokines are much lessabundant. However, because the vast majority of these arememory T cells, IL-17 is upregulated in early...
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Báo cáo y học:

Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

... stage of the model [15]. On the other hand, it could be possiblethat the suppressive function of regulatory T cells is switched off under the inflammatory conditions present in the inflamed tissue ... the pathogenesis of chronic arthritis. Transfer of such cells canmodulate the severity of ongoing inflammatory arthritis butthey cannot suppress established disease. Thus, timing of Treg cell transfer ... cells. The exact role played by naturally occurring CD4+CD25+Treg cells in the pathogenesis of arthritis remains controver-sial. Arthritis is part of the autoimmune syndrome inducedby transfer...
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Báo cáo y học: "The importance of localizing pulmonary veins in atrial septal defect closure" ppsx

... arterial phase depicts the anomalous systemic artery (arrow) arising from the celiac trunk andintending to supply the base of the right lung, which is ligated at the level of the diaphragm.Amirghofran ... original work is properly cited.was measured at 6-7 mmHg, then the A zyos vein wasclamped immediately before its drainage into the SVC and the pressure readings gradually increased and establishedat ... the 7 mm vessel showed 97% oxygen saturation and upon itsclamping the flow through the anastomosis stoppedimplying that the 7 mm vessel was a systematic arterywhich was supplying part of the...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf

... survival, MyD88 does play a dis-tinct role in the adaptive immune response to influenzathrough regulation of B -cell isotype switching [95,96].TheroleofTLR3intheimmuneresponsetoinflu-enza ... T LRsignaling. In addition to TLRs, a variety of other PRRs including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation. For example, the cyto-plasmic ... activation of antiviral response pathways includ-ing the intracellular signaling adaptor protein IPS-1 and the kinase PKR.Defective innate immunity may predispose to acuteexacerbations of COPD...
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Báo cáo y học: " The effectiveness of problem solving therapy in deprived South African communities: results from a pilot study" pps

... SANPAD hadno involvement in study design, in the collection, analysis, and interpretation of data, in the writing of the report or in the decision to submit the paperfor publication. The authors ... countries may be less likely to acknowledge psychobiological factors in psychologicaldistress. This may affect attitudes regarding the kind of help needed and the acceptability of mental healthinterventions. ... determine the best mode and type of mental health treatment in these settings. An increasingnumber of studies show the potential of group interven-tions for mental disorders in L AMICs. Bolton...
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