Báo cáo y học: " Control of allergic rhinitis and asthma test – a formal approach to the development of a measuring tool" ppt
Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... proinflamma-tory cytokine and is related to several inflammatory diseasessuch as rheumatoid arthritis (RA) and inflammatory bowel dis-eases (IBDs). RA is a persistent inflammatory arthritis and ... PCRHuman IL-32 Sense 5'-TGAGGAGCAGCACCCAGAGC-3'Antisense 5'-CCGTAGGACTGGAAAGAGGA-3'Human TNFα Sense 5'-GTCTCCTACCAGACCAAG-3'Antisense 5'-CAAAGTAGACCTGCCCAGACTC-3'Human ... 5'-TGGGAGTAGACAAGGTACAACCC-3'Mouse IL-1β Sense 5'-CAACCAACAAGTGATATTCTCCATG-3'Antisense 5'-GATCCACACTCTCCAGCTGCA-3'Mouse IL-6 Sense 5'-CACTTCACAAGTCGGAGGCTTA-3'Antisense...
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Báo cáo y học: " Control of allergic rhinitis and asthma test – a formal approach to the development of a measuring tool" ppt
... ensure the face and content validity and the overall quality of the instrument's design.AbbreviationsARA: allergic rhinitis and asthma; ARIA: Allergic Rhinitis and its Impact on Asthma; CARAT: ... 1 of 9(page number not for citation purposes)Respiratory ResearchOpen AccessResearch Control of allergic rhinitis and asthma test – a formal approach to the development of a measuring toolLuis ... purposes)Introduction Allergic rhinitis and asthma (ARA) are inflammatory dis-eases and are often associated. The lack of control of thesediseases is responsible for a significant loss in patient'squality...
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Báo cáo y học: "Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge" pdf
... sea-son. Eight patients had a diagnosis of allergic seasonal asthma, having respiratory symptoms (wheeze and dys-pnea) and denying nasal symptoms during birch pollenseason, and thus were categorised ... categorised as h aving asthma as the predominant symptom. Nine patients were diagnosedwith allergic rhinitis, having eye and nose symptoms and denying respiratory symptoms, and consequently cate-gorised ... afterbronchial allergen challenge than the asthmatic patients.One interpretation could be that the granulocytes of the patients with allergic asthma are easier to prime and activate, particularly after...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... factors in the pathogenesis of rheumatoid arthritis?Aleksi Sedo1, Jonathan S Duke-Cohan2, Eva Balaziova1 and Liliana R Sedova31Laboratory of Cancer Cell Biology of the 1stFaculty of ... Shioda T, Kato H, Ohnishi Y, Tashiro K, Ikegawa M, Nakayama EE,Hu H, Kato A, Sakai Y, Liu H, et al.: Anti-HIV-1 and chemotacticactivities of human stromal cell-derived factor 1alpha (SDF-1alpha) ... extravasation, and from cartilage breakdown to the release of chemokines and cytokines that attract new T cells and monocytes, therebyincreasing the inflammatory response and exacerbatingdegeneration....
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Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
... (a) Early stages of apoptosis were assayed by immunoblot with an antibody specific for intact and cleaved forms of poly(ADP ribose) polymerase (PARP). No cleavage of PARP (i.e. appearance of ... cartilage. Maintaining integrity of the nuclearmaterial is critical, and the repair of damaged DNA isdependent on PARP. When a cell initiates apoptosis,PARP is targeted by caspase 3 and caspase ... collagenmRNA. The pharmacological inhibitor of MEK1/2 sup-pressed mRNA loss and changes in cell morphology. The MAPK/ERK pathway is thereby at least partially involved inregulating the aggrecan and type...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... protein kinases suchas extracellular signal-related kinase and c-Jun N-terminal kinase, and inhibition of the nuclear translocation of the transcription factors AP-1 and nuclear factor of activated ... cell therapy of chronic inflammations.Polymorphisms of CTLA-4 in rheumatoidarthritis (RA) and other autoimmune diseases The human CD28 and CTLA-4 genes map to chromo-some 2q33 and are separated ... formation cannot occur by the interaction of CD86 with CTLA-4. Activation of CTLA-4 by binding to its ligands leads to the phosphorylation of tyrosine residues in the cytoplasmic tail of CTLA-4 and...
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Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf
... a micropipette. In the pretreatment protocol,rats were treated four times on day –1 4, day –1 1, day –7 and day –4 , preceding AA induction. In the treatment pro-tocol, treatment was started after ... Supplementary material).Altogether, these results indicate that the selected MMP epi-topes are naturally processed and presented during arthritis, and that they are able to activate MMP-specific ... several factors such as adjuvant use,antigen dose and the route of antigen administration (asreviewed in [10]). Nasal antigen administration appears to be an especially efficient way to induce...
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Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
... factors favoring the catabolic side is very likely involved in the pathological fea-tures of OA.Currently, many attempts are being made to repair the carti-lage that has been damaged in OA. ... maintenance and appears to be a good candidate for cartilage repair. TGF-β is a stimulator of extracellular matrix production, like collagentype II and proteoglycan (PG), in chondrocytes and it ... participated in the animal experiments and immunohis-tochemistry, carried out the histological measurements, ana-lyzed the data, and drafted the manuscript. ELV participated in the animal experiments,...
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Báo cáo y học: "Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model" doc
... TJ was in charge of he statistical evaluation. MSchconceived of the study, and participated in its design and coordination and draft the manuscript. All authors read and approved the final manuscript.AcknowledgementsThis ... infiltration and tissue damage.BackgroundHemorrhagic shock is a leading cause of complications and death in combat casualties and civilian trauma [1]. Ithas been shown to cause systemic inflammatory ... dehydrogenase (GAPDH)(hGAPDH-R: 5'-GAAGTCAGAGGAGACCACCA-3'; -F:5'-CACCACCATGGAGAAGGCTG-3', Genosys-Sigma,Munich, Germany) were used as controls. 2.5 μl of cDNAwere amplified...
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