Báo cáo y học: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis" docx
Báo cáo y học: "Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study" pps
... present study indicates that HTLV-I infection couldmodify the inflammatory activity of ordinary primary OA,whereby direct activation by Tax protein might account forthe increased concentrations ... possible that the alteredinflammatory activity is partial and transient during the nat-ural course of OA and does not continue to the final stage. In contrast to the development of systemic arthritis ... hypothesis.Taken together, our results suggest that HTLV-I infectioncan alter the pathophysiology of OA by increasing the expression of inflammatory cytokines, but this modificationdoes not...
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Báo cáo y học: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis" docx
... suggestingthat TIM-1 controls critical regulatory pathways in theimmune system. Studies on mice have indicated that TIM-1 is involved in T helper cell differentiation and suggestedthat the protein ... represent a T cell defect to control the Th1 response, which might contrib-ute to the accumulation of inflammatory cells in the lungsand the pathogenesis of sarcoidosis.Competing interestsThe authors ... response in the lungs of patients with Löfgren's syndrome and those without. The triggering event is the presentation of an (unknown) antigen by antigen-presenting cells (APC) to T cells. In the...
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Báo cáo y học: "Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal" pps
... circa-dian rhythms in the rats, with peak activity occurring atnight. Our results showed that the expression of mPER1 in the kidneys was higher at night in the control mice, coin-ciding with the peak ... neuropeptide pituitary adenylyl cyclase activatingpeptide (PACAP) as the principal neurotransmitters forlight entrainment [21]. In order to optimize the bodily function of different organsystems, ... oscillation of mPER1 protein in the kidney and alter the phase of theoscillation in the brain. These results strongly suggest thatmorphine addiction and withdraw may lead to desyn-chronization of...
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Báo cáo y học: "Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawa" docx
... stability test. The validity of this systemis further demonstrated through the observation of 2 rats in constant dark conditions thatdisplayed the expected free running of their circadian rhythm.Conclusion: ... minute) in front of the system during 10 hours. Sincethe metronome signal is stable in time, we tested thedetection stability of our system. We also applied a short-time Fourier transform to ... spectrograms obtainedat the beginning and at the end of the test. This procedureallowed us to detect any potential drift of signal detection in time, leading to false increase or decrease in...
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Báo cáo y học: "Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis" doc
... role in the regula-tion of apoptosis. In this study we systematically investigated the expression and interplay of the Fas/FasL system in fibroblastsobtained from patients with and without lung ... process that is highly selective in eliminating aged and injured cells. In addition to inter-nal pathways that mainly trigger apoptosis in response tocytotoxic stress, apoptosis can also be induced ... characterized by a1.6-fold increase in production of extracellular matrixproteins, particularly collagen. The findings suggest thatthese cells retained their fibrotic differentiation state in short-term...
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Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" ppsx
... SLEpatients and healthy control individuals, although interpreta-tion of this finding is limited by the inability of the anti-CD32antibody to distinguish the activating FcγRIIa and inhibitoryFcγRIIb. ... facilitate the infiltration of these cells to the sites of IC deposition in the kidney [48]. Since IFNα and IFNγ alsostimulate the production of monocyte attractants such asMCP-1, the presence of ... patients.FcγRI/CD6hi monocytes have an activated phenotypeMonocyte migration to the kidneys and the subsequentrelease of inflammatory mediators are thought to be criticalsteps initiating...
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Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" pdf
... monocytes between the SLEpatients and healthy control individuals, although interpreta-tion of this finding is limited by the inability of the anti-CD32antibody to distinguish the activating ... participated in statistical analysis. MSassisted in data interpretation. MSS participated in acquisition of data and patient recruitment. WHR carried out the studydesign and data interpretation, ... alsostimulate the production of monocyte attractants such asMCP-1, the presence of these cytokines in the kidney also maypromote the influx of monocytes. In turn, signal transductiondownstream of FcγRI/CD64...
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Báo cáo y học: "Polarized expression of the membrane ASP protein derived from HIV-1 antisense transcription in T cells" potx
... CTCCA-CAATTAAAACTG-3’ (sense) and 5’-GTCCATGGCTG-TAATTCAACACAACTGTTTAATAGTAC-3’ (anti-sense). Primers permitting the addition of a Flag tag at theCOOH end of the ASP ORF, 5’ -CATGGGACTACAClerc et ... Propensityfor HBZ-SP1 isoform of HTLV-I to inhibit c-Jun activity correlates withsequestration of c-Jun into nuclear bodies rather than inhibition of itsDNA-binding activity. Virology 2009, ... confirmed thatintracellular levels of viral proteins were not affected (datanot shown). The effect of the mutation was also investi-gated on the structure of the viral particle by electronmicroscopy...
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Báo cáo y học: "Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-κB activation" pps
... example,the transforming activity of Tax1 is abrogated by muta-tions that impair the ability of Tax1 to activate NF-κB [24-26]. Tax1 inhibits apoptosis of mouse T- cell lines byinduction of the anti-apoptotic ... constitutively active as seen in HTLV-1 transformed cells [33]. It appears that this consti-tutive NF-κB activation contributes to the survival andchemotherapy resistance of ATL cells, since treatment ... library to the retrovirallibrary by introduction into packaging cells, the resultantviruses were transduced into the Rat-1 κB-bsrEGFPx2reporter cells. After selection in the presence of blasticidin,under...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... distilled water. Finally, sections werecounterstained in hematoxylin for 30 s and mounted in AQUATEXÒ(Merck, Darmstadt, Germany).Statistical analysesThe paired Student’s t- test (two-tailed) ... event in viable cells that marks a process rela-ted with the cell cycle status [45]. In this context, it isimportant to stress that DNA content studies did notshow significant differences in ... cells. At the level of thehepatocyte, CD1d redistribution may in uence quanti-tatively and qualitatively the intracellular lipid pool byeither intracellular release and ⁄ or extracellular uptake.At...
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