Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... (Stage
I) and tiny collagen fibers in the lung of rats in the sil-
ica+Lv-shCD36 group. Compared to the silica and the sil-
ica+Lv-shCD36-NC groups, the number of nodules in the
lungs of rats in the ... silencing expression of CD36 inhib-
its activation of L-TGF-β1, which results in reduced
hydroxyproline, collagen synthesis, and further preve...
... corresponding signature:
where Q is the set of genes in the signature, n
Q
is the num-
ber of genes in Q, x
i
is the expression of gene i, and w
i
is
either -1 or +1 depending on its concordance index ... datasets in our survival analysis, we
kept only the common genes between these two platforms
(10,540 genes); we kept 10% of the genes for which the
varia...
... tension and cell-ECM interactions.
Our results and those of others demonstrate the complex
regulatory network that exists in the developing lung, and
how the myofibroblast plays a key role in driving ... cells. The inset in D (secondary antibody only) shows minimal levels of
Alexa Fluor-568 staining in the absence of the primary antibody. Scale bars are 20...
... genes in our study appeared in
one or more of the lists of genes identified as being involved
in immunity in the microbial pathogen studies in adults, and
only 8-10% of the genes in our study were ... associations between the serpent/
GATA-type motifs and the genes in cluster 2, many of which
had been annotated as being involved in immunity, and the
R...
... patterns of expression between the
retina, brain, and mouse platform were determined by miR
microarray profiling. The results of the study suggest that the
relative magnitude in expression of widely ... upregulated,
expression of their targets may possibly be suppressed in
P347S mice. Many genes encoding factors that are involved in
mRNA processing and splici...
... 4).
Protein Fingerprint Analysis of Serum Samples
in Patients with CRC and Healthy Controls
The protein profile of the serum samples from
the 98 patients with CRC and the 80 healthy controls ... tool for integrating separation and analysis
of complex mixtures of proteins. Captured proteins
are then analyzed by TOF-MS, generating a spectral
map depicting approximatio...
... Proline, hydroxyproline and
hydroxylysine were examined at 254 nm by reverse-phase
HPLC of their phenylisothiocarbamate derivatives [26], as
reported previously [20]. The serine, threonine and tyrosine
contents ... Hydroxyproline, hydroxy-
lysine and phosphoserine were not detected in WSM, WIM,
EDTA-SM and EDTA-IM.
The comparison of the amino acid composition of the
ma...
... alternate interpretation of the lack of agonist-induced
BRET observed in this study is that the translation of
agonist binding to the ATDs of the family C GPCR
homodimer into G-protein coupling of the ... 2002
Agonist-induced rearrangement of the 7TMs
in the CaR homodimer?
One of the goals of the present study was to investigate,
whether the activating...
... non-inflammatory conditions [2].
Most chemokines play a role in inflammatory conditions by
inducing integrin activation, chemotaxis, and angiogenesis.
Apart from modulating migration directly, ... abundant expression of a variety of
inflammatory chemokines and their receptors [5,6]. In vitro
studies have suggested that both so-called homeostatic
chemokines and inflammatory ch...
... processes
underlying RP and PAH contribute to the familiar pattern of
skin, renal and gastrointestinal pathology. The emergence of
effective and conveniently administered therapy for PAH
increases the importance ... vasculopathy of SScl may
also be modifiable.
In the characteristic microangiopathy of SScl, luminal
narrowing results from a combination of intimal pro...