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Báo cáo y học: " Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension" pot

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Báo cáo y học: "Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits" ppt

... the induction of arthritis in both knee jointsby ovalbumin injection into the joint spaces of pre-immunizedrabbits, increasing daily doses of adrenomedullin were injectedinto the knee joint ... Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan4Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty ... Chosa11Division of Orthopedic Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan2Section of Pathophysiology,...
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Báo cáo y học: "Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice" pot

... Laboratories).Fluorescent staining of lymphoid cells in spleens and kidneysFrozen sections were used for examination of lymphoid cellsubsets in spleen and cell infiltration in kidneys. For determina-tion of CD3+ ... Yang MS: Involvement of NF-kappaB and c-mycsignaling pathways in the apoptosis of HL-60 cells induced byalkaloids of Tripterygium hypoglaucum (levl.) Hutch. Phyto-medicine 2004, 11:295-302.43. ... deposition in kidneysIgG and C3 staining was observed only in glomeruli and theintensity of IgG and C3 was correlated with the severity of pro-teinuria (Fig. 4a,b,e,f). Remarkable deposition of both...
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Báo cáo y học: "Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis" docx

... production during thisphase of GPI-induced arthritis.Figure 4Concentration of inflammatory cytokines in serum of mice with GPI-induced arthritisConcentration of inflammatory cytokines in serum of mice ... suggesting that IL-6 is alsopathologically crucial in the early effector phase in arthritis.Role of various inflammatory cytokines in GPI-induced arthritisTo determine the effects of inflammatory ... anti-gen results in induction of TNF-α and IFN-γ by immunocytes,and suggest that these cytokines could play a crucial role in the induction of arthritis in GPI-induced mice.Anti-cytokine mAbs and...
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Báo cáo y học: "Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis" pot

... (Figure2b). In contrast, STA-5326-treated mice exhibited someinflammatory cell infiltration into the vitreous cavity, but only afew infiltrating cells in the retina with retinal layers remainingintact ... likely that STA-5326 blocksc-Rel translocation in ocular tissues and infiltrating inflamma-tory cells, including ocular antigen presenting cells, resulting in inhibition of gene expression of ... at 72 hours were assayed by ELISA. (a-d) Statistical analysis was performed using Student;s t-test. (e and f) Intracellular cytokine staining of draining lymph node cells in 20 mg/kg STA-5326...
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Báo cáo y học: " Comparative efficacy of the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for early onset chronic depression: design and rationale of a multisite randomized controlled trial" ppt

... Department of Clinical and Developmental Psychol-ogy, University of Tuebingen, (Site Principal Investiga-tor: Martin Hautzinger, PhD);2) Department of Psychiatry, University of Heidelberg(Site Principal ... Katrin Wambach,PhD);5) Department of Psy chiatry and P sychotherapy, Uni-versity of Luebeck, Germany (Site Principa l Investigator:Philipp Klein, MD);6) Department of Psychiatry; University ... orientation of the sites (dept. of psychology, psychosomatic medicine, and psychiatry andpsychotherapy) allows the generalization of the results.AcknowledgementsThis study is funded by a grant of the...
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Báo cáo y học: "Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature" doc

... phototherapy in psoriasis.HBO2therapy may have a place in the management of psoriasis. Further studies including large numbers of patients and involving monitoring cytokines and inflam-matory mediators ... and cytokines involved in wound pathophysiology and inflammation in particularwere recently reviewed [8]. That review indicates thatHBO2has important effects on the biology of cytokinesand ... decompression.Undersea HyperbMed 1999, 26:27-39.15. Benson M, Minter M, Osborne B, Granowitz E: Hyperbaric oxygeninhibits stimulus-induced proinflammatory cytokine synthesisby human blood-derived monocyte-macrophages....
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Báo cáo y học: "The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient

... enhanced in 1% copper sulphate for 10min. Finally, sections were counterstained in Mayer’s haematoxylin, dehydrated through the as-cending graded alcohols, cleared in xylol and finally coverslipped ... feature of various cancers including cancer of the co-lon [33]. The amino acid analysis of the purified mucin gave high amounts of ‘mucin-like amino acids, serine, threonine and proline. Serine ... 4.5 Isoleucine (I) 2.9 Leucine (L) 3.3 Tyrosine (Y) 1.2 Phenylalanine (F) 1.6 Histidine (H) 12.9 Lysine (K) 1.9 Arginine (R) 1.7 Total 100 4. DISCUSSION Early work by Bara et al...
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Báo cáo y học: " Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphis"

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely-sium Pty Ltd, ... pathogenesis of AML. During sequence analysis of exon 10 in the AML samples we identified a new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 healthy individuals. Interestingly, ... individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients with AML and 13,7% in healthy individuals. After...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"

... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the ... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in this high-risk...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

... determinant for the transcrip-tional regulation of the drug metabolizing enzyme family of heme-containing monooxygenases P450 CYP3A [1–4].Consequently this nuclear receptor is likely to play a ... thehistidine residue makes a hydrogen bond to SR12813 in one of its binding modes. The mutation of this residue gave anumber of surprising results suggesting that this residue playa key role in receptor ... model of human PXR in order to identifyresidues that were likely to be involved in ligand binding.Since the initiation of this study the crystal structure of thehuman receptor has been published...
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